Results 71 to 80 of about 15,286 (297)

A flexible and dissolving traditional Chinese medicine microneedle patch for sleep-aid intervention

open access: yesHeliyon
About a quarter of the world's population suffers from insomnia, and the number of the insomniacs is gradually increasing. However, the current drug therapy and non-drug therapy sleep-aid methods have certain limitations. In general, the sleep-aid effect
Chunhua He   +6 more
doaj   +1 more source

3D Printed Polypyrrole Microneedle Arrays for Electronically Controlled Transdural Drug Release

open access: yes, 2020
Thesis (Master's)--University of Washington, 2020The secondary injury causes further damage to neural cells, due to mechanisms of inflammation and cytotoxicity.
Huang, Joyce
core  

Graphene‐Interfaced Stretchable Sweat Patch for Multiplexed Electrochemical Monitoring of IL‐6, Glucose, and Calcium Ions

open access: yesAdvanced Materials Technologies, EarlyView.
Flexible sweat sensor patch integrating graphene‑interfaced gold microelectrodes functionalized with bio‑receptors and ion‑selective membrane, coupled with a capillary‑driven microfluidic layer and portable potentiostat electronics for multiplexed monitoring of inflammatory, metabolic, and electrolyte biomarkers in microliter sweat volumes.
Roomia Memon   +4 more
wiley   +1 more source

Multiphoton‐Printed Microrobotic Arrays Powered by Discrete, Monolithically Integrated Hydrogel Actuators

open access: yesAdvanced Robotics Research, EarlyView.
Functional surfaces are investigated as a foundation for reconfigurable microscale systems with sensing and actuation capabilities. Advances in additive manufacturing enable our development of planar arrays of hybrid‐material, compliant microdevices that convert environmental stimuli into programmed motion and visual responses.
Sandra Edward   +5 more
wiley   +1 more source

Research Progress in Wearable Microneedle Sensors for Health Analysis

open access: yesAdvanced Sensor Research
In this modern era, wearable biosensors have emerged as a significant innovation in specialized personal healthcare. While smartphones and smartwatches today can easily measure vital signs and mobility, a new generation of wearable technology quickly ...
Adnan Zameer   +3 more
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

open access: yesAdvanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang   +6 more
wiley   +1 more source

Self‐Assisted Charge Storage‐Release Mechanism Enabling Flexible Design of Biomimetic Triboelectric Nanogenerators

open access: yesAdvanced Science, EarlyView.
Inspired by the mimosa, this study develops a flexible triboelectric nanogenerator with a novel microneedle array and battery‐mimetic architecture. The device introduces a spontaneous charge self‐regulation mechanism that confines the electric field below the air breakdown threshold, and achieves an outstanding charge density of 396.50 µC m−2 ...
Hanpeng Gao   +7 more
wiley   +1 more source

Human Growth Hormone Delivery with a Microneedle Transdermal System: Preclinical Formulation, Stability, Delivery and PK of Therapeutically Relevant Doses

open access: yesPharmaceutics, 2014
This study evaluated the feasibility of coating formulated recombinant human growth hormone (rhGH) on a titanium microneedle transdermal delivery system, Zosano Pharma (ZP)-hGH, and assessed preclinical patch delivery performance.
Mahmoud Ameri   +7 more
doaj   +1 more source

Transdermal Delivery of an mRNA‐Liposome Vaccine via Dissolving Microneedle to Preserve Vaccine Activity and Enhance Immune Activation

open access: yesAdvanced Science, EarlyView.
An mRNA‐liposome vaccine via dissolving microneedles (ML‐DMN) enables efficient skin‐targeted delivery while preserving mRNA integrity and allowing sustained antigen expression. Unlike intramuscular (IM) injection, ML‐DMN engages skin‐resident immune cells, activates antigen‐presenting cells (APCs), and induces strong T cell and cytokine responses at ...
Jeehye Nam   +9 more
wiley   +1 more source

Anti-arthritic effects of microneedling with bee venom gel

open access: yesJournal of Traditional Chinese Medical Sciences, 2016
Objective: To combine with transdermal drug delivery using microneedle to simulate the bee venom therapy to evaluate the permeation of bee venom gel. Methods: In this study, the sodium urate and LPS were used on rats and mice to construct the model.
Mengdi Zhao   +8 more
doaj   +1 more source

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