Results 61 to 70 of about 18,959 (275)

Rapid prototyping and customizable microneedle design: Ultra-sharp microneedle fabrication using two-photon polymerization and low-cost micromolding techniques

, 2021
In recent years, interest in microneedle devices for drug and vaccine delivery and point-of-care diagnostics has grown due to low cost, convenience and minimal invasiveness.
Faraji Rad, Zahra, Davies, Graham, Prewett, Philip, Philip D. Prewett, Graham J. Davies, Zahra Faraji Rad   +5 more
core   +1 more source

Modelling microneedle assisted micro-particle delivery [PDF]

, 2014
Modelling microneedle assisted micro-particle ...
Diganta Das (1254000), Dongwei Zhang (350860)   +1 more
core   +5 more sources

Advanced Flexible Robotic Systems for the Early Diagnosis and Treatment of Cancer and Cardiovascular Diseases

Advanced Robotics Research, EarlyView.
Flexible surgical robots are advancing minimally invasive interventions for cardiovascular diseases and cancer by enabling precise navigation through complex, submillimeter anatomical pathways. This review highlights recent innovations in actuation, bio‐integrated sensing, AI‐assisted control, and friction‐reduction technologies, discusses current ...
Hermione Truong, Chi Cong Nguyen, Hannah Thuy Truong, Kefan Zhu, Adrienne Ji, James Davies, Emanuele Nicotra, Bibhu Sharma, Jingjing Wan, Patrick Pruscino, Shing Wai Wong, Hoang‐Phuong Phan, Phuoc Thien Phan, Nigel H. Lovell, Thanh Nho Do   +14 more
wiley   +1 more source

Assessment of solid microneedle rollers to enhance transmembrane delivery of doxycycline and inhibition of MMP activity

Drug Delivery, 2017
Many chronic wounds exhibit high matrix metalloproteinase (MMP) activity that impedes the normal wound healing process. Intradermal delivery (IDD) of sub-antimicrobial concentrations of doxycycline, as an MMP inhibitor, could target early stages of ...
Abbie Omolu, Maryse Bailly, Richard M. Day   +2 more
doaj   +1 more source

Microneedle-Mediated Delivery of Lipid-Coated Cisplatin Nanoparticles for Efficient and Safe Cancer Therapy

, 2018
Cisplatin is the first-line chemotherapeutic agent, but its systemic toxicity and side effects severely limit its clinical use. We report a microneedle technique to mediate the transdermal delivery of lipid-coated cisplatin nanoparticles (LCC-NPs) for ...
Yu-xiong Su, Di-an Lin, Xuan Li (137217), Xinmiao Lan, Xi Xie, Vivian Wai Yan Lui (5782262), Yu-xiong Su (396407), Xuan Li, Lijian Jin (294684), Wei-fa Yang, Juncong She, Xi Xie (310180), Lijian Jin, Xinmiao Lan (5782256), Di-an Lin (5540405), Juncong She (2249668), Wei-fa Yang (5782259), Yu Xu (52257), Yu Xu, Vivian Wai Yan Lui   +19 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

In Situ Genetic Engineering Facilitates MMP‐9‐Responsive TIMP1 Release Through Proteolytic Cleavage to Boost Diabetic Wound Healing

Advanced Science, EarlyView.
This study develops an MMP‐9‐responsive protein release system that transforms resident cells into drug depots through in situ genetic engineering. Anchored to the membrane, the therapeutic protein TIMP1 is selectively released upon MMP‐9 cleavage.
Yuan Zhang, Jiani Deng, Man Yee Cheung, Tingting Fu, Xufeng Qi, Dongqing Cai, Jianmin Sun, Gang Lu, Peng Shi, Wai‐Yee Chan, Xu Li, Hui Zhao   +11 more
wiley   +1 more source

A flexible and dissolving traditional Chinese medicine microneedle patch for sleep-aid intervention

Heliyon
About a quarter of the world's population suffers from insomnia, and the number of the insomniacs is gradually increasing. However, the current drug therapy and non-drug therapy sleep-aid methods have certain limitations. In general, the sleep-aid effect
Chunhua He, Zewen Fang, Heng Wu, Xiaoping Li, Lianglun Cheng, Yangxing Wen, Juze Lin   +6 more
doaj   +1 more source

Organoid Brain‐Machine‐Interface Devices for Central Nervous System Repair

Advanced Science, EarlyView.
We envision organoid brain‐machine‐interface (Organoid‐BMI) devices as new biohybrid bidirectional communication pathways to connect the human CNS and the external world for personalized CNS repair and regeneration. ABSTRACT Central nervous system (CNS) repair and regeneration suffer from tremendous clinical challenges due to current limitations in ...
Yantao Xing, Yang Yang, Zichen Hong, Chunhui Tian, Huiyu Chu, Susanne Clara Prokop, Hongwei Cai, Mingxia Gu, Jason Tchieu, Ken Mackie, Feng Guo   +10 more
wiley   +1 more source

Microvascular effects of microneedle application

, 2021
Background The efficiency of transdermal drug delivery may be increased by pretreating the skin with microneedles, but distinct effects of microneedles and the microneedle-enhanced delivery of vasoactive drugs on the skin microvasculature are still not ...
Tesselaar, Erik, Johannes Hackethal, Hackethal, Johannes, Henricson, Joakim, Chris D. Anderson, Iredahl, Fredrik, Anderson, Chris,, Joakim Henricson, Anderson, Chris, Iredahl, Fredrik,, Henricson, Joakim,, Erik Tesselaar, Hackethal, Johannes,, Fredrik Iredahl, Tesselaar, Erik,   +14 more
core   +1 more source