Results 71 to 80 of about 37,259 (377)

Towards pain-free diagnosis of skin diseases through multiplexed microneedles: biomarker extraction and detection using a highly sensitive blotting method [PDF]

, 2015
Immunodiagnostic microneedles provide a novel way to extract protein biomarkers from the skin in a minimally invasive manner for analysis in vitro.
A Bhargav, AA Ansari, AV Romanyuk, B Yeow, C Ericsson, CG Li, DA Muller, DV McAllister, G Gremel, HS Gill, JM Skehel, JR Lakowicz, JW Coffey, KT Lee, L Fuertes, L Fuertes, LM Strambini, LM Strambini, M Pilar Martin Del, MI Haq, N Cai, NC Shaner, RF Donnelly, SM Bal, SR Corrie, T-M Tuan-Mahmood, W Schramm, Y Zhu, Y-C Kim   +28 more
core   +2 more sources

Microneedles’ Device: Design, Fabrication, and Applications

Macromol
The delivery of therapeutical molecules through the skin, particularly to its deeper layers, is impaired due to the stratum corneum layer, which acts as a barrier to foreign substances. Thus, for the past years, scientists have focused on the development
Cristiana Oliveira, J. Teixeira, Nelson Oliveira, Sónia Ferreira, C. Botelho   +4 more
semanticscholar   +1 more source

Suprachoroidal and Subretinal Injections of AAV Using Transscleral Microneedles for Retinal Gene Delivery in Nonhuman Primates. [PDF]

, 2020
Retinal gene therapy using adeno-associated viruses (AAVs) is constrained by the mode of viral vector delivery. Intravitreal AAV injections are impeded by the internal limiting membrane barrier, while subretinal injections require invasive surgery and ...
Chung, Sook Hyun, Mollhoff, Iris N, Nguyen, Uyen Tu, Noronha, Glenn, Taraborelli, Donna, Thomasy, Sara M, Yiu, Glenn, Yoo, Jesse   +7 more
core  

Inkjet printing of transdermal microneedles for the delivery of anticancer agents [PDF]

, 2015
A novel inkjet printing technology is introduced as a process to coat metal microneedle arrays with three anticancer agents 5-fluororacil, curcumin and cisplatin for transdermal delivery.
Arora, Babur Chowdhry, Bierwagen, Chabri, Chen, Chen, Choi, Chu, Dennis Douroumis, Donnelly, Donnelly, Gill, Graham, Henry, Hensel, Katikaneni, Kim, Kim, Kochhar, Larrañeta, Lee, Lee, Li, Lin, Maniruzzaman, Mark R. Prausnitz, McAllister, Md Jasim Uddin, Mulik, Nicolaos Scoutaris, Nir, Pavlos Klepetsanis, Simonsen, Tarcha, Tian, van der Maaden, Yan   +36 more
core   +1 more source

Inkjet printing of insulin microneedles for transdermal delivery [PDF]

, 2015
Inkjet printing technology was used to apply insulin polymeric layers on metal microneedles for transdermal delivery. A range of various polymers such as gelatin (GLN), polyvinyl caprolactame-polyvinyl acetate-polyethylene glycol (SOL), poly(2-ethyl-2 ...
Douroumis, Dennis, Lamprou, Dimitrios, Mallinson, David, Ross, Steven, Scoutaris, Nikolaos   +4 more
core   +1 more source

Hydrogel‐Forming Microneedles and Applications in Interstitial Fluid Diagnostic Devices

Advanced Healthcare Materials
Hydrogel‐forming microneedles are constructed from or coated with polymeric, hydrophilic materials that swell upon insertion into the skin. Designed to dissolve or disintegrate postinsertion, these microneedles can deliver drugs, vaccines, or other ...
Angélica F Aroche, Hannah E. Nissan, Michael A. Daniele   +2 more
semanticscholar   +1 more source

Down-Regulating Scar Formation by Microneedles Directly via a Mechanical Communication Pathway

ACS Nano, 2022
Excessive extracellular matrix deposition drives fibroblasts into a state of high mechanical stress, exacerbating pathological fibrosis and hypertrophic scar formation, leading to tissue dysfunction. This study reports a minimally invasive and convenient
Qing Zhang, Lin Shi, Hong-Yang He, Xingmou Liu, Yong Huang, Dan Xu, Mengyun Yao, Ning Zhang, Yicheng Guo, Y. Lu, Haisheng Li, Jun-yi Zhou, Jianglin Tan, M. Xing, G. Luo   +14 more
semanticscholar   +1 more source

Sugar-Triggered Burst Drug Releasing Poly-Lactic Acid (PLA) Microneedles and Its Fabrication Based on Solvent-Casting Approach

Pharmaceutics, 2022
Microneedles have emerged as a novel transdermal delivery tool that enables the delivery of various products such as drugs, vaccines, or cosmetic ingredients. Although the demand for solid microneedles composed of biocompatible polymer is increasing, the
Seongsu Kang, Ji Eun Song, Seung-Hyun Jun, Sun-Gyoo Park, Nae-Gyu Kang   +4 more
doaj   +1 more source

Investigation of Plasma Treatment on Micro-Injection Moulded Microneedle for Drug Delivery [PDF]

, 2015
YesPlasma technology has been widely used to increase the surface energy of the polymer surfaces for many industrial applications; in particular to increase in wettability.
Grant, Colin A., Nair, Karthik Jayan, Norris, Keith, Paradkar, Anant R., Patel, Rajnikant, Tuinea-Bobe, Cristina-Luminita, Whiteside, Benjamin R.   +6 more
core   +2 more sources

Microneedling with dermaroller

Journal of Cutaneous and Aesthetic Surgery, 2009
Microneedling with dermaroller is a new treatment modality for the treatment of scars, especially acne scars, stretch marks, wrinkles, and for facial rejuvenation. It is a simple and relatively cheap modality that also can be used for transdermal drug delivery.
openaire   +2 more sources