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Venous Leg Ulcer: A Meta-analysis of Adjunctive Therapy with Micronized Purified Flavonoid Fraction [PDF]

European Journal of Vascular and Endovascular Surgery, 2005
To assess the effect of oral treatment with micronized purified flavonoid fraction (MPFF) on leg ulcer healing.Meta-analysis of randomised prospective studies using MPFF in addition to conventional treatment.Five prospective, randomised, controlled studies in which 723 patients with venous ulcers were treated between 1996 and 2001 were identified ...
C Lok, A -A Ramelet
exaly   +3 more sources

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Effect of a Micronized Purified Flavonoid Fraction on in Vivo Platelet Functions in the Rat

Thrombosis Research, 1999
The aim of this study was to investigate the effects of a micronized purified flavonoid fraction (MPFF) on in vivo rat platelet functions. Platelet aggregation and disaggregation were evaluated by a noninvasive, automated isotope monitoring system (AimsPlus).
John L McGregor, L Lerond, Cecile Rousselle   +2 more
exaly   +3 more sources

The impact of micronized purified flavonoid fraction on the treatment of acute haemorrhoidal episodes

Current Medical Research and Opinion, 2006
To evaluate the efficacy and the tolerability of micronized purified flavonoid fraction (MPFF) on symptoms and signs of acute haemorrhoidal disease (HD).Patients experiencing an acute HD episode for less than 48 h were enrolled in this randomized, double-blind, placebo-controlled study (n = 90 in two hospital-based study centres in Beijing).
Zhu-Ming, Jiang, Jin-Duo, Cao
exaly   +3 more sources

Efficacy of micronized purified flavonoid fraction in treatment of chronic venous oedema

Angiology and vascular surgery, 2020
The purpose of the study was to assess efficacy and safety of using in real clinical practice micronized purified flavonoid fraction (Detralex) in patients with chronic venous oedema.The study enrolled a total of 708 patients presenting with chronic venous disease, belonging to C3EpAsPr according to the CEAP classification (chronic venous oedema), who.
V Iu, Bogachev, B V, Boldin, P Iu, Turkin, A Iu, Samenkov   +3 more
openaire   +2 more sources

The Effect of Purified Micronized Flavonoid Fraction on the Healing of Anastomoses in the Colon in Rats

Surgery Today, 2006
Anastomotic leakage of colonic and rectal anastomoses is a major complication after large intestine surgery. Many factors influence the healing of colon anastomoses. Flavonoids have been recognized for centuries as physiologically active constituents that are used to treat human diseases.
Inan, Aydin, Koca, CEMİLE, Dener, Cenap, Akpinar, Ayhan, Şen, Meral   +4 more
openaire   +3 more sources

Effects of a Purified Micronized Flavonoid Fraction on Capillary Filtration in Diabetic Patients

Diabetic Medicine, 1996
The objective of the present study was to investigate the effects of a purified micronized flavonoid fraction (Daflon 500 mg) on the increased capillary filtration of albumin (CFA) which is an early change in the microcirculation of patients with diabetes.
P E, Valensi, A, Behar, M M, de Champvallins, M, Attalah, F C, Boulakia, J R, Attali   +5 more
openaire   +2 more sources

Micronized Purified Flavonoid fraction-based Conservative Treatment of Chronic Venous Disease in a real-world Setting

Future Cardiology, 2022
Aims: To investigate the effectiveness and tolerability of adjunctive micronized purified flavonoid fraction (MPFF) in patients with chronic venous disease (CVD). Patients & methods: This observational study included adults (≥18 years) with clinical-etiology-anatomy-pathophysiology (CEAP) class C4 CVD for whom MPFF was indicated.
Vadim, Bogachev, Boris, Boldin, Pavel, Turkin, Alexander, Samenkov, Olga, Dzhenina   +4 more
exaly   +3 more sources

Conservative management of hemorrhoids: A comparison of venotonic flavonoid micronized purified flavonoid fraction (MPFF) and sclerotherapy

Surgery Today, 2008
To compare the results of the conservative management of hemorrhoids between venotonic flavonoid micronized purified flavonoid fraction (MPFF) and sclerotherapy, in terms of the subjective and objective outcome of patients after a follow-up period of 2 years.One hundred and twenty-six patients who suffered from 1st-and 2nd-degree hemorrhoids were ...
Bulent C, Yuksel, Halil, Armagan, Huseyin, Berkem, Yiğit, Yildiz, Hakan, Ozel, Suleyman, Hengirmen   +5 more
openaire   +2 more sources

Efficacy of two micronized purified flavonoid fraction dosing regimens in the pelvic venous pain relief

International Angiology, 2021
The venoactive drug treatment regimen for pelvic venous disorders (PeVDs) is not finally established. The study aimed at assessing the efficacy of micronized purified flavonoid fraction (MPFF) in a standard or double dose in the pelvic venous pain (PVP) relief in PeVD.We analyzed the treatment efficacy in 125 female patients with PeVD, who were ...
Sergey G, Gavrilov, Anatoly V, Karalkin, Yekaterina P, Moskalenko, Anastasiya S, Grishenkova   +3 more
openaire   +2 more sources

Perioperative administration of micronized purified flavonoid fraction in endovascular treatment of varicose disease

Angiology and vascular surgery, 2019
The study was aimed at assessing efficacy and safety of using a micronized purified flavonoid fraction in the perioperative period in patients scheduled for endovascular surgical intervention for CEAP clinical class C2 lower limb varicose veins.This study enrolled a total of 1519 patients with CEAP C2a,sEpAs (primary varicose vein with valvular ...
V Iu, Bogachev, B V, Boldin, P Iu, Turkin   +2 more
openaire   +2 more sources