Results 191 to 200 of about 32,768 (229)

Figure 7 from Claudin-4 Modulates Autophagy via SLC1A5/LAT1 as a Mechanism to Regulate Micronuclei

Fabian R. Villagómez, Julie Lang, Fredrick J. Rosario, Daniel Núñez-Avellaneda, Patricia Webb, Margaret Neville, Elizabeth R. Woodruff, Benjamin G. Bitler   +7 more
openalex   +1 more source

Oncogene Silencing via ecDNA Micronucleation

Brückner L, Xu R, Tang J, Herrmann A, Wong IT, Zhang S, Tu F, Pilon M, Kukalev A, Pardon K, Sidorova O, Atta J, Yu Q, Pradella D, Ilić M, Novais-Cruz M, Kaltenbach S, Treue D, Giurgiu M, Herzog S, Hollinger A, Fernandez M, Becker F, Louma V, Schmargon R, Dörr J, Gamlin D, Lehmann A, Gürgen D, Richter M, Dubois F, Simeoni F, Pennycook BR, Hamilton A, Lindemann RK, Fischer M, Bafna V, Wahl G, Koche RP, Chang HY, Papathanasiou S, Medema R, Spanjaard B, Ventura A, Pombo A, Huang W, Werner B, Mischel PS, Henssen AG.   +48 more
europepmc   +1 more source

Causes and consequences of micronuclei

Current Opinion in Cell Biology, 2021
Micronuclei are small membrane-bounded compartments with a DNA content encapsulated by a nuclear envelope and spatially separated from the primary nucleus. Micronuclei have long been linked to chromosome instability, genome rearrangements, and mutagenesis. They are frequently found in cancers, during senescence, and after genotoxic stress.
Ksenia, Krupina, Alexander, Goginashvili, Don W, Cleveland   +2 more
openaire   +3 more sources

Micronuclei and Cancer

Cancer Discovery
Abstract Chromosome-containing micronuclei are a feature of human cancer. Micronuclei arise from chromosome mis-segregation and characterize tumors with elevated rates of chromosomal instability. Although their association with cancer has been long recognized, only recently have we broadened our ...
Melody Di Bona, Samuel F. Bakhoum
openaire   +3 more sources

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Micronuclei, inflammation and auto-immune disease

Mutation Research - Reviews in Mutation Research, 2020
Auto-immune diseases (AUD) are characterized by an immune response to antigenic components of the host itself. The etiology of AUD is not well understood. The available evidence points to an interaction between genetic, epigenetic, environmental, infectious and life-style factors. AUD are more prevalent in women than in men; sex hormones play a crucial
Micheline Kirsch-Volders, Claudia Bolognesi, Marcello Ceppi, Marco Bruzzone, Michael Fenech   +4 more
openaire   +5 more sources

Measurement of micronuclei in lymphocytes

Mutation Research/Environmental Mutagenesis and Related Subjects, 1985
The micronucleus technique has been proposed as a method for measurement of chromosomal damage in mitogen-stimulated human lymphocytes. Micronuclei require one cell division to be expressed and, consequently, the conventional micronucleus technique is very imprecise since the cells which have undergone only one division, and the micronuclei in them ...
M, Fenech, A A, Morley
openaire   +3 more sources

Fate of micronuclei and micronucleated cells

Mutation Research/Reviews in Mutation Research, 2017
The present review describes available evidence about the fate of micronuclei and micronucleated cells. Micronuclei are small, extranuclear chromatin bodies surrounded by a nuclear envelope. The mechanisms underlying the formation of micronuclei are well understood but not much is known about the potential fate of micronuclei and micronucleated cells ...
Henning, Hintzsche, Ulrike, Hemmann, Albrecht, Poth, Dietmar, Utesch, Jasmin, Lott, Helga, Stopper   +5 more
openaire   +3 more sources

Preprint Highlight: Mitotic clustering of pulverized chromosomes from micronuclei.

Molecular Biology of the Cell, 2022
Chromosomes in micronuclei are fragmented into small pieces, sometimes catastrophically. Such severely damaged chromosomes can lead to genomic rearrangements, but how the chromosome fragments segregate during mitosis is unknown.
Huaiying Zhang
semanticscholar   +1 more source