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Fate of micronuclei and micronucleated cells
Mutation Research - Reviews in Mutation Research, 2017The present review describes available evidence about the fate of micronuclei and micronucleated cells. Micronuclei are small, extranuclear chromatin bodies surrounded by a nuclear envelope. The mechanisms underlying the formation of micronuclei are well understood but not much is known about the potential fate of micronuclei and micronucleated cells ...
Henning Hintzsche +2 more
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CGAS is a micronucleophagy receptor for the clearance of micronuclei [PDF]
Autophagy, 2021 Micronuclei are constantly considered as a marker of genome instability and very recently found to be a trigger of innate immune responses. An increased frequency of micronuclei is associated with many diseases, but the mechanism underlying the regulation of micronuclei homeostasis remains largely unknown.
Xiangyang Wu +2 more
exaly +3 more sources
Biochemistry (Moscow), 2016
The presence of micronuclei in a cell is an indicator of DNA damage and genetic instability. In this review, mechanisms of emergence of micronuclei, their functional activity, and pathways of elimination are discussed. It is supposed that morphological and functional varieties of micronuclei as well as their degradation pathways can be determined by ...
O P, Kisurina-Evgenieva +2 more
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The presence of micronuclei in a cell is an indicator of DNA damage and genetic instability. In this review, mechanisms of emergence of micronuclei, their functional activity, and pathways of elimination are discussed. It is supposed that morphological and functional varieties of micronuclei as well as their degradation pathways can be determined by ...
O P, Kisurina-Evgenieva +2 more
openaire +2 more sources
Measurement of micronuclei in lymphocytes
Mutation Research/Environmental Mutagenesis and Related Subjects, 1985The micronucleus technique has been proposed as a method for measurement of chromosomal damage in mitogen-stimulated human lymphocytes. Micronuclei require one cell division to be expressed and, consequently, the conventional micronucleus technique is very imprecise since the cells which have undergone only one division, and the micronuclei in them ...
M, Fenech, A A, Morley
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Micronuclei with multiple copies of the X chromosome: do chromosomes replicate in micronuclei? [PDF]
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2004 The formation of a micronucleus due to chromosome lagging is a well known mechanism of chromosomal loss. However, the post-mitotic fate of the micronucleus and the chromosomal DNA within it is poorly understood. We observed micronuclei (MN) that had multiple copies of the X chromosome (ranging from 4 to 10) when analyzing cultured human lymphocytes ...
Colleen Jackson-Cook
exaly +3 more sources
Micronuclei in Human Alveolar Macrophages
Respiration, 2009Occurrence of micronuclei was monitored in pulmonary alveolar macrophages collected from 31 individuals undergoing diagnostic bronchoalveolar lavage. The overall frequency of micro nucleated cells was 3.88 ± 1.84%₀, without any significant difference attributable to sex, age, pathology, occupation, or smoking habits.
D'AGOSTINI, FRANCESCO +3 more
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Long-term fate of etoposide-induced micronuclei and micronucleated cells in Hela-H2B-GFP cells
Archives of Toxicology, 2020 Micronuclei are small nuclear cellular structures containing whole chromosomes or chromosomal fragments. While there is a lot of information available about the origin and formation of micronuclei, less is known about the fate of micronuclei and ...
Helga Stopper +2 more
exaly +2 more sources
Cancer Discovery
Abstract Chromosome-containing micronuclei are a feature of human cancer. Micronuclei arise from chromosome mis-segregation and characterize tumors with elevated rates of chromosomal instability. Although their association with cancer has been long recognized, only recently have we broadened our ...
Melody Di Bona, Samuel F. Bakhoum
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Abstract Chromosome-containing micronuclei are a feature of human cancer. Micronuclei arise from chromosome mis-segregation and characterize tumors with elevated rates of chromosomal instability. Although their association with cancer has been long recognized, only recently have we broadened our ...
Melody Di Bona, Samuel F. Bakhoum
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The non-induction of micronuclei by quinacrine
Mutation Research, 1975Quinacrine (atabrine), formerly used in the treatment of malaria and now better known as Q-banding stain in cytogenetics, is a rapidly acting cell poison killing mice at a dose level of 15o mg/kg in a matter of minutes.
Maier, P, Schmid, Werner
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Chromium‐induced micronuclei in fish
Journal of Applied Toxicology, 1994AbstractAn investigation of the cytogenetic effects of chromium (Cr(VI) and Cr(III)) in Prussian carp (Carassius auratus gibelio) was made. For detecting cytogenetic damage, micronuclei induction in fish erythrocyte cells was employed. Fish were investigated 100 m above and 400 m below the discharge of leather waste products into the river Ljubljanica,
K, al-Sabti +4 more
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