Results 231 to 240 of about 24,177 (264)
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Mutation Research/Genetic Toxicology, 1981
Micronuclei time response and the effects of multiple treatments of mutagens on induction of micronuclei were studied. In the time-response investigation, mice were treated once with each of 5 mutagens, then killed at various times. The bone marrow was examined for the presence of micronucleated erythrocytes (MNEs).
K I, Yamamoto, Y, Kikuchi
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Micronuclei time response and the effects of multiple treatments of mutagens on induction of micronuclei were studied. In the time-response investigation, mice were treated once with each of 5 mutagens, then killed at various times. The bone marrow was examined for the presence of micronucleated erythrocytes (MNEs).
K I, Yamamoto, Y, Kikuchi
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This chapter provides a brief overview about micronuclei and their postmitotic fate. Micronuclei are small chromatin-containing bodies formed during mitosis and located in the cytoplasm. Micronuclei have been known for more than 100 years and used as biomarkers for decades, but their fate after formation and with that their biological relevance for the
Henning, Hintzsche, Helga, Stopper
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Henning, Hintzsche, Helga, Stopper
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Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2007
Diabetes mellitus (DM) is associated with a high risk of health complications, mainly due to excessive free radical (FRs) production that could result in an increased frequency of micronuclei. The consumption of antioxidants, like folic acid (FA), may mitigate the effects of the FRs. In the present study, micronucleated polychromatic erythrocyte (MNPCE)
Guillermo M, Zúñiga-González +7 more
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Diabetes mellitus (DM) is associated with a high risk of health complications, mainly due to excessive free radical (FRs) production that could result in an increased frequency of micronuclei. The consumption of antioxidants, like folic acid (FA), may mitigate the effects of the FRs. In the present study, micronucleated polychromatic erythrocyte (MNPCE)
Guillermo M, Zúñiga-González +7 more
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Cinnamaldehyde-induced micronuclei in rodent liver
Mutation Research/Genetic Toxicology, 1994Cinnamaldehyde, a widely used flavoring agent, has so far been subjected to a limited range of genotoxicity tests, mainly carried out in vitro, which produced contradictory results. Therefore we have examined cinnamaldehyde using additional in vivo genotoxicity end-points.
E. Mereto +4 more
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Micronuclei in Diabetics and Smokers
Research Journal of Pharmacy and Technology, 2015Aim: This article reviews the MN assay with respect to oral buccal mucosa, which has been used since the 1980s to demonstrate the characteristics of micronuclei and frequency of micronuclei in smokers and diabetes. Objective: To compare the frequency of micronuclei and metanucleated anomalies in the oral mucosa of smokers and diabetes.
S. Bharathi, null Gheena
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Micronuclei, inflammation and auto-immune disease
Mutation Research - Reviews in Mutation Research, 2020Auto-immune diseases (AUD) are characterized by an immune response to antigenic components of the host itself. The etiology of AUD is not well understood. The available evidence points to an interaction between genetic, epigenetic, environmental, infectious and life-style factors. AUD are more prevalent in women than in men; sex hormones play a crucial
Micheline Kirsch-Volders +4 more
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The role of micronuclei in chromatin elimination
Žurnal obŝej biologiiMicronuclei are the extra-nuclear chromatin compartments separated from the primary nucleus and surrounded by their own nuclear envelope. For a long time it has been thought that micronuclei is the final stage of the pathological process in a cell. They have been used as biomarkers of the influence of genotoxic factors as well as of genome instability ...
Yu. R. Akhmadullina, P. O. Khomenko
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cGAS Conducts Micronuclei DNA Surveillance
Trends in Cell Biology, 2017DNA damage elicits a potent proinflammatory immune response. A collection of four papers now reveals that micronuclear DNA is a new cell intrinsic immunostimulatory molecule, and that accumulation of the immune sensor cyclic GMP-AMP synthase (cGAS) in micronuclei leads to a cell-cycle-dependent proinflammatory response following DNA damage.
Carina C, de Oliveira Mann +1 more
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Chromosome painting of radiation-induced micronuclei
International Journal of Radiation Biology, 1996In this report, in situ hybridization with whole chromosome painting probes was used to paint radiation-induced micronuclei (MN) in three lymphoblastoid cells lines to investigate the frequency of radiation-induced MN. The results obtained for four different chromosomes showed that there was a significant deviation of the numbers of signal-positive MN ...
A, Slavotinek +4 more
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DNA Content of Micronuclei in Human Lymphocytes
International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, 1985We have calculated the distribution of DNA contents in micronuclei (MN) induced by ionizing radiation in human lymphocytes on two assumptions: the MN arise from acentric chromosome fragments (ACF), and the ACF result from the random breakage and rejoining of chromosomes.
M, Pincu, H, Callisen, A, Norman
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