Results 201 to 210 of about 26,946 (241)
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Measurement of micronuclei in lymphocytes
Mutation Research/Environmental Mutagenesis and Related Subjects, 1985The micronucleus technique has been proposed as a method for measurement of chromosomal damage in mitogen-stimulated human lymphocytes. Micronuclei require one cell division to be expressed and, consequently, the conventional micronucleus technique is very imprecise since the cells which have undergone only one division, and the micronuclei in them ...
M, Fenech, A A, Morley
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Micronuclei with multiple copies of the X chromosome: do chromosomes replicate in micronuclei? [PDF]
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2004 The formation of a micronucleus due to chromosome lagging is a well known mechanism of chromosomal loss. However, the post-mitotic fate of the micronucleus and the chromosomal DNA within it is poorly understood. We observed micronuclei (MN) that had multiple copies of the X chromosome (ranging from 4 to 10) when analyzing cultured human lymphocytes ...
Colleen Jackson-Cook
exaly +3 more sources
Long-term fate of etoposide-induced micronuclei and micronucleated cells in Hela-H2B-GFP cells
Archives of Toxicology, 2020 Micronuclei are small nuclear cellular structures containing whole chromosomes or chromosomal fragments. While there is a lot of information available about the origin and formation of micronuclei, less is known about the fate of micronuclei and ...
Henning Hintzsche, Helga Stopper
exaly +2 more sources
Micronuclei in Human Alveolar Macrophages
Respiration, 2009Occurrence of micronuclei was monitored in pulmonary alveolar macrophages collected from 31 individuals undergoing diagnostic bronchoalveolar lavage. The overall frequency of micro nucleated cells was 3.88 ± 1.84%₀, without any significant difference attributable to sex, age, pathology, occupation, or smoking habits.
D'AGOSTINI, FRANCESCO +3 more
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Cancer Discovery
Abstract Chromosome-containing micronuclei are a feature of human cancer. Micronuclei arise from chromosome mis-segregation and characterize tumors with elevated rates of chromosomal instability. Although their association with cancer has been long recognized, only recently have we broadened our ...
Melody Di Bona, Samuel F. Bakhoum
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Abstract Chromosome-containing micronuclei are a feature of human cancer. Micronuclei arise from chromosome mis-segregation and characterize tumors with elevated rates of chromosomal instability. Although their association with cancer has been long recognized, only recently have we broadened our ...
Melody Di Bona, Samuel F. Bakhoum
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Chromium‐induced micronuclei in fish
Journal of Applied Toxicology, 1994AbstractAn investigation of the cytogenetic effects of chromium (Cr(VI) and Cr(III)) in Prussian carp (Carassius auratus gibelio) was made. For detecting cytogenetic damage, micronuclei induction in fish erythrocyte cells was employed. Fish were investigated 100 m above and 400 m below the discharge of leather waste products into the river Ljubljanica,
K, al-Sabti +4 more
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The non-induction of micronuclei by quinacrine
Mutation Research, 1975Quinacrine (atabrine), formerly used in the treatment of malaria and now better known as Q-banding stain in cytogenetics, is a rapidly acting cell poison killing mice at a dose level of 15o mg/kg in a matter of minutes.
Maier, P, Schmid, Werner
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Mutation Research/Genetic Toxicology, 1981
Micronuclei time response and the effects of multiple treatments of mutagens on induction of micronuclei were studied. In the time-response investigation, mice were treated once with each of 5 mutagens, then killed at various times. The bone marrow was examined for the presence of micronucleated erythrocytes (MNEs).
K I, Yamamoto, Y, Kikuchi
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Micronuclei time response and the effects of multiple treatments of mutagens on induction of micronuclei were studied. In the time-response investigation, mice were treated once with each of 5 mutagens, then killed at various times. The bone marrow was examined for the presence of micronucleated erythrocytes (MNEs).
K I, Yamamoto, Y, Kikuchi
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This chapter provides a brief overview about micronuclei and their postmitotic fate. Micronuclei are small chromatin-containing bodies formed during mitosis and located in the cytoplasm. Micronuclei have been known for more than 100 years and used as biomarkers for decades, but their fate after formation and with that their biological relevance for the
Henning, Hintzsche, Helga, Stopper
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Henning, Hintzsche, Helga, Stopper
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Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2007
Diabetes mellitus (DM) is associated with a high risk of health complications, mainly due to excessive free radical (FRs) production that could result in an increased frequency of micronuclei. The consumption of antioxidants, like folic acid (FA), may mitigate the effects of the FRs. In the present study, micronucleated polychromatic erythrocyte (MNPCE)
Guillermo M, Zúñiga-González +7 more
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Diabetes mellitus (DM) is associated with a high risk of health complications, mainly due to excessive free radical (FRs) production that could result in an increased frequency of micronuclei. The consumption of antioxidants, like folic acid (FA), may mitigate the effects of the FRs. In the present study, micronucleated polychromatic erythrocyte (MNPCE)
Guillermo M, Zúñiga-González +7 more
openaire +2 more sources