Results 201 to 210 of about 32,768 (229)
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Biochemistry (Moscow), 2016
The presence of micronuclei in a cell is an indicator of DNA damage and genetic instability. In this review, mechanisms of emergence of micronuclei, their functional activity, and pathways of elimination are discussed. It is supposed that morphological and functional varieties of micronuclei as well as their degradation pathways can be determined by ...
O P, Kisurina-Evgenieva +2 more
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The presence of micronuclei in a cell is an indicator of DNA damage and genetic instability. In this review, mechanisms of emergence of micronuclei, their functional activity, and pathways of elimination are discussed. It is supposed that morphological and functional varieties of micronuclei as well as their degradation pathways can be determined by ...
O P, Kisurina-Evgenieva +2 more
openaire +2 more sources
International Journal of Radiation Biology, 2021
Purpose Ionizing radiations trigger the formation of free radicals that damage DNA and cause cell death. DNA damage may be simply evaluated by micronucleus assay and the pharmacophores that impede free radicals could effectively reduce the DNA damage ...
G. Jagetia
semanticscholar +1 more source
Purpose Ionizing radiations trigger the formation of free radicals that damage DNA and cause cell death. DNA damage may be simply evaluated by micronucleus assay and the pharmacophores that impede free radicals could effectively reduce the DNA damage ...
G. Jagetia
semanticscholar +1 more source
Micronuclei in Human Alveolar Macrophages
Respiration, 1992Occurrence of micronuclei was monitored in pulmonary alveolar macrophages collected from 31 individuals undergoing diagnostic bronchoalveolar lavage. The overall frequency of micronucleated cells was 3.88 +/- 1.84/1000, without any significant difference attributable to sex, age, pathology, occupation, or smoking habits.
D'AGOSTINI, FRANCESCO +3 more
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cGAS Conducts Micronuclei DNA Surveillance
Trends in Cell Biology, 2017DNA damage elicits a potent proinflammatory immune response. A collection of four papers now reveals that micronuclear DNA is a new cell intrinsic immunostimulatory molecule, and that accumulation of the immune sensor cyclic GMP-AMP synthase (cGAS) in micronuclei leads to a cell-cycle-dependent proinflammatory response following DNA damage.
Carina C, de Oliveira Mann +1 more
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Chromium‐induced micronuclei in fish
Journal of Applied Toxicology, 1994AbstractAn investigation of the cytogenetic effects of chromium (Cr(VI) and Cr(III)) in Prussian carp (Carassius auratus gibelio) was made. For detecting cytogenetic damage, micronuclei induction in fish erythrocyte cells was employed. Fish were investigated 100 m above and 400 m below the discharge of leather waste products into the river Ljubljanica,
K, al-Sabti +4 more
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Cytokinesis Blocked Micronuclei Aberration Analysis
2022Cytokinesis blocked micronuclei (CBMN) assay is a rapid and sensitive analysis of chromosome aberrations and miss assortments during cell division. Genotoxic agent exposure produces DNA damage and chromosome fragments. Fragmented chromosomes without centromere failed to attach kinetochore which segregates a pair of homologous chromosomes to each ...
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Cinnamaldehyde-induced micronuclei in rodent liver
Mutation Research/Genetic Toxicology, 1994Cinnamaldehyde, a widely used flavoring agent, has so far been subjected to a limited range of genotoxicity tests, mainly carried out in vitro, which produced contradictory results. Therefore we have examined cinnamaldehyde using additional in vivo genotoxicity end-points.
E. Mereto +4 more
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Chromosome painting of radiation-induced micronuclei
International Journal of Radiation Biology, 1996In this report, in situ hybridization with whole chromosome painting probes was used to paint radiation-induced micronuclei (MN) in three lymphoblastoid cells lines to investigate the frequency of radiation-induced MN. The results obtained for four different chromosomes showed that there was a significant deviation of the numbers of signal-positive MN ...
A, Slavotinek +4 more
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Transient hypothermia induces micronuclei in mice
Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 1998We investigated the effect of hypothermia on micronucleus induction in mouse bone marrow cells. To induce hypothermia, we administered chlorpromazine, which was negative in an in vitro chromosome aberration test, at 3.13, 6.25, 12.5, 25, 50, and 100 mg/kg intraperitoneally.
S, Asanami, K, Shimono, S, Kaneda
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Micronuclei in X-irradiated human lymphocytes
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1988The dose-effect relationship of the frequency of micronuclei in cytokinesis-blocked human lymphocytes after in vitro irradiation of whole blood in the range from 0.2 to 4 Gy was studied. The linear-quadratic response obtained offers a useful technique for dose assessments in cases of radiation injuries above approx. 0.1 Gy whole body dose.
C, Kormos, G J, Köteles
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