Results 211 to 220 of about 32,768 (229)
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Genetic activities in micronuclei: Is the DNA entrapped in micronuclei lost for the cell?
Mutation Research/Reviews in Mutation Research, 2010Micronuclei are good markers of genotoxic exposure in humans and their scoring has been extensively used to identify potential genotoxic agents. Micronuclei are also indicators of chromosomal instability, since the frequency of micronuclei is higher in tumour cells and cells with a defective DNA damage repair system or disrupted cell cycle checkpoint ...
Mariona, Terradas +3 more
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Micronuclei kinetics of exfoliated urothelial cells
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 1996Micronuclei observed in exfoliated cells result from DNA-damage of basal epithelium's cells by mutagens. Exfoliated urothelial cells can be collected by non-invasive procedure and may be used as target site to identify genotoxic effects of chemicals. Kinetic studies are important for any biomarker, especially those in which tissue differentiation and ...
M P, Lehucher-Michel +4 more
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Sorting of micronuclei from PtK1 cells
Experimental Cell Research, 1986We report here a procedure allowing to select micronuclei corresponding to defined individualized chromosomes in conditions which preserve their synthetic activity. The mammalian PtK1 cells, which possess six chromosome pairs, were micronucleated by colchicine.
D, Hernandez-Verdun +3 more
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Micronuclei Formation Analysis After Ionizing Radiation
2019Micronuclei are formed by broken chromosome fragments or chromosomes, which were not appropriately separated into the daughter cells' nuclei after division. The appearance of micronuclei is typically a sign of genotoxic events. Majority of micronuclei are formed by broken acentric fragments, but some micronuclei are formed by centric chromosome ...
Cathy, Su +2 more
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International Journal of Radiation Biology, 2019
Purpose: The regular low dose occupational exposure to ionizing radiation may induce deleterious health effects, which may be of particular interest to medical radiation workers who daily handle X-ray machines. Human peripheral blood lymphocytes are able
Zothan Siama +5 more
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Purpose: The regular low dose occupational exposure to ionizing radiation may induce deleterious health effects, which may be of particular interest to medical radiation workers who daily handle X-ray machines. Human peripheral blood lymphocytes are able
Zothan Siama +5 more
semanticscholar +1 more source
Electromagnetic Fields and Micronuclei
2019Epidemiological findings indicate that exposure to high frequency electromagnetic fields (HF-ELF), which are used for mobile telecommunications, and also to extremely low frequency magnetic fields (from usage of electric current) may cause cancer in humans.
H. Al-Serori +4 more
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Micronuclei in irradiated meristems
Radiation Botany, 1963The percentages of cells with micronuclei counted at intervals after acute x irradiation of the root meristems of Zea mays show two peaks. These two peaks occur clearly only after heavy doses (900 and 1800 rads) and only when restricted regions of the root tip are considered, not when squashes of whole tips are used.
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Recent achievements in micronuclei characterization
2023Among numerous genotoxicity assays, the micronucleus (MN) test is especially recommended to evaluate the genotoxic effects of chemical and physical agents. MN test is less time-consuming and easier to perform compared to the chromosomal aberrations (CA) assays. An analysis of the MN frequency is the basis for genotoxicity assessment.
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Understanding the birth of rupture-prone and irreparable micronuclei
Chromosoma, 2020Xihan Guo +6 more
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