Oral Acute Toxicity and Genotoxicity of Heteroctenus junceus Scorpion Venom [PDF]
Veterinary Medicine and ScienceObjective The study evaluates the elemental composition, oral acute toxicity, genotoxicity, and mutagenic potential of Heteroctenus junceus scorpion venom.
Alexis Díaz‐García +4 more
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Micronucleus test using formalin-fixed rat glandular stomach and colon [PDF]
Genes and Environment, 2023 Background Genotoxicity in tissues other than hematopoietic tissues, such as the liver and gastrointestinal (GI) tract, is an important focus in the risk assessment of chemicals in humans. We previously developed a rat micronucleus test for the GI tract,
Wakako Ohyama +4 more
doaj +2 more sources
Vicia–Micronucleus Test Application for Saline Irrigation Water Risk Assessment [PDF]
Plants, 2022 In view of climate change, increasing soil salinity is expected worldwide. It is therefore important to improve prediction ability of plant salinity effects. For this purpose, brackish/saline irrigation water from two areas in central and coastal Tunisia
Dalila Souguir +4 more
doaj +2 more sources
The micronucleus test-most widely used in vivo genotoxicity test. [PDF]
Genes Environ, 2016 Genotoxicity is commonly evaluated during the chemical safety assessment together with other toxicological endpoints. The micronucleus test is always included in many genotoxic test guidelines for long time in many classes of chemicals, e.g., pharmaceutical chemicals, agricultural chemicals, food additives.
Hayashi M.
europepmc +4 more sources
Genotoxicity of Di (2-ethyl hexyl) phthalate
Zhongguo shipin weisheng zazhi, 2022 ObjectiveTo assess the genotoxicity of Di（2-ethylhexyl） phthalate （DEHP）.MethodsA series of guideline-compliant assays were performed to evaluate mutagenicity， chromosomal or DNA damage of DEHP， including Ames test， in vitro mammalian chromosome ...
LI Juntao +9 more
doaj +1 more source
In vitro micronucleus assay: Method for assessment of nanomaterials using cytochalasin B
Frontiers in Toxicology, 2023 The in vitro micronucleus (MNvit) assay is used to evaluate the aneugenic and clastogenic potential of a test material based upon its ability to induce micronuclei in the cells.
Christopher S. Farabaugh +3 more
doaj +1 more source
Cytogenetic effect of caffeine in the micronucleus test
RUDN Journal of Medicine, 2021 Relevance. The consumption of caffeine-containing food in the modern world must necessarily be safe for humans, including should not affect the hereditary material of the body.
N. A. Durnova +4 more
doaj +1 more source
Absence of genotoxic effects of the chalcone (E)-1-(2-hydroxyphenyl)-3-(4-methylphenyl)-prop-2-en-1-one) and its potential chemoprevention against DNA damage using in vitro and in vivo assays. [PDF]
PLoS ONE, 2017 The chalcone (E)-1-(2-hydroxyphenyl)-3-(4-methylphenyl)-prop-2-en-1-one), or 2HMC, displays antileishmanial, antimalarial, and antioxidant activities. The aim of this study was to investigate the cytotoxic, genotoxic, mutagenic, and protective effects of
Débora Cristina da Silva Lima +5 more
doaj +1 more source
Acute Oral Toxicity and Genotoxicity Test and Evaluation of Cinnamomum camphora Seed Kernel Oil
Foods, 2023 Cinnamomum camphora seed kernel oil (CCSKO) is one of the important natural medium chain triglycerides (MCT) resources, with more than 95.00% of medium chain fatty acids found in the world, and has various physiological effects.
Pengbo Wang +10 more
doaj +1 more source
Acute toxicity and genotoxicity studies on new melatonergic antidepressant GW117
Heliyon, 2023 GW117, a novel derivate compound of agomelatine that acts as both a 5-HT2C receptor antagonist and a MT1/MT2 receptor agonist, likely underlines the potent antidepressant action with less hepatotoxicity than agomelatine.
Mei Gao +8 more
doaj +1 more source