The micronucleus test-most widely used in vivo genotoxicity test. [PDF]
Genes Environ, 2016 Genotoxicity is commonly evaluated during the chemical safety assessment together with other toxicological endpoints. The micronucleus test is always included in many genotoxic test guidelines for long time in many classes of chemicals, e.g., pharmaceutical chemicals, agricultural chemicals, food additives.
Hayashi M.
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Comprehensive interpretation of in vitro micronucleus test results for 292 chemicals: from hazard identification to risk assessment application. [PDF]
Arch Toxicol, 2022 Risk assessments are increasingly reliant on information from in vitro assays. The in vitro micronucleus test (MNvit) is a genotoxicity test that detects chromosomal abnormalities, including chromosome breakage (clastogenicity) and/or whole chromosome ...
Kuo B +8 more
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Micronucleus test using formalin-fixed rat glandular stomach and colon [PDF]
Genes and Environment, 2023 Background Genotoxicity in tissues other than hematopoietic tissues, such as the liver and gastrointestinal (GI) tract, is an important focus in the risk assessment of chemicals in humans. We previously developed a rat micronucleus test for the GI tract,
Wakako Ohyama +4 more
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Clinical and Experimental Health Sciences, 2021 Objective: Nanotechnology is an emerging technology which has wide applications in many fields. Prime concern of research in nanotechnology is the synthesis of nano-material with the controlled size and shape.
M.V. Patel +3 more
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Vicia–Micronucleus Test Application for Saline Irrigation Water Risk Assessment [PDF]
Plants, 2022 In view of climate change, increasing soil salinity is expected worldwide. It is therefore important to improve prediction ability of plant salinity effects. For this purpose, brackish/saline irrigation water from two areas in central and coastal Tunisia
Dalila Souguir +4 more
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MICRONUCLEUS TEST OF MOFEZOLAC (N-22)
The Journal of Toxicological Sciences, 1990 A micronucleus test using BDF1 male mice was conducted in order to evaluate the in vivo mutagenicity of mofezolac (N-22). N-22 was orally administered at doses of 75, 150, 300 and 600 mg/kg, with a sampling time of 24 hr. The frequency of polychromatic erythrocytes with micronuclei was 0.07-0.08% in the groups treated with N-22 and did not differ ...
A, Ohuchida, A, Furukawa
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Evaluation of Genotoxicity by Micronucleus Assay in vitro and by Allium cepa Test in vivo
Bio-Protocol, 2019 The in vitro and in vivo genotoxicity of new metallodrugs either as Small Bioactive Molecules (SBAMs) or Conjugates of Metals with Drugs (CoMeDs) is evaluated by the micronucleus test and the Allium cepa assay, respectively.
Christina Banti, Sotiris Hadjikakou
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Assessment of methyl methacrylate genotoxicity by the micronucleus test
Brazilian Oral Research, 2013 The aim of this study was to evaluate the genotoxic potential of methyl methacrylate (MMA) vapor by simulating standard occupational exposure of 8 hours per day and using the micronucleus test. We used 32 adult male Wistar rats divided into three groups:
Amarildo Mariano de Araújo +4 more
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A study for the genotoxicity assessment of substances containing probiotic candidates in the in vitro TK6 cell micronucleus test: Influence of low pH conditions and antibiotic supplementation on the test results. [PDF]
Genes EnvironFujiishi Y, Ohyama W, Okada E.
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Analytical method cross validation by HPLC for identification of five markers and quantification of one marker in SynacinnTM formulations and its in vivo bone marrow micronucleus test data. [PDF]
Data Brief, 2021 Zainol SN +10 more
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