Results 121 to 130 of about 27,228 (257)
Genotoxicity evaluation of So-ochim-tang-gamibang (SOCG), a herbal medicine
BMC Complementary and Alternative Medicine, 2018 Background So-ochim-tang-gamibang (SOCG) is a traditional Korean medicine frequently used for depression in the clinical field. In this study, we evaluated the potential genotoxicity of SOCG using three standard batteries of tests as part of a safety ...
Mi Young Lee +5 more
doaj +1 more source
Micronucleus test for determining genotoxic damage
Turkish Bulletin of Hygiene and Experimental Biology, 2011 Micronuclei (MN) are formed during mitosis and do not integrate in the main nucleus. They may arise from a whole lagging chromosome or an acentric chromosome fragment. An increase of MN frequency indicates genomic instability. The MN test is commonly used to determine the genotoxic effects of chemical and physical agents on somatic cells. It is applied
Vedat Sekeroglu, Zulal Atli Sekeroglu
openaire +1 more source
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, Volume 20, Issue 3, Page 727-752, March 2026.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Formation of viable cell fragments by treatment with colchicine [PDF]
, 1976 Time-lapse cinematography of human fibroblasts revealed that mitotic cells separated into numerous cell fragments containing varying amounts of chromatin and cytoplasm when treated with colchicine.
Abercrombie +18 more
core +1 more source
Cancer Medicine, Volume 15, Issue 3, March 2026.ABSTRACT Introduction Centrosome clustering is a cancer‐specific adaptation that allows cells with centrosome amplification to evade mitotic catastrophe and has emerged as a potential therapeutic target. We analyzed the prognostic role of several molecules related to centrosome clustering and found that Kinesin Family Member C1 (KIFC1) was strongly ...
Yoshinori Nakano +14 more
wiley +1 more source
Replication of somatic micronuclei in bovine enucleated oocytes
Cell Division, 2012 Background Microcell-mediated chromosome transfer (MMCT) was developed to introduce a low number of chromosomes into a host cell. We have designed a novel technique combining part of MMCT with somatic cell nuclear transfer, which consists of injecting a ...
Canel Natalia +3 more
doaj +1 more source
Development of a micronucleus test using the EpiAirway™ organotypic human airway model. [PDF]
Genes Environ, 2023 Munakata S +5 more
europepmc +1 more source
Triazine‐Naphthalimide Cage for the Recognition of Nucleotides and Parallel G‐Quadruplex
ChemistryEurope, Volume 4, Issue 3, March 2026.A cage‐like receptor is designed by combining a triazine‐based macrocycle with a naphthalimide dye. The modular construction enables the recognition of various sites on the G‐quadruplex, specifically the phosphate residues and guanine quartets. This design approach provides strong and selective binding of parallel G‐quadruplex over double‐stranded DNA ...
Maryam Akhgar, Evgeny A. Kataev
wiley +1 more source
Reply to the opinion paper: is micronucleus test a suitable method for monitoring oral mucosa exposed to dental bleachings in smokers? [PDF]
Arch Toxicol, 2023 Silva RR +7 more
europepmc +1 more source
Rapid Adaptation to Road Salts in a Freshwater Microbial Eukaryote
Ecology and Evolution, Volume 16, Issue 3, March 2026.Road salt application is causing increased salinization of freshwater ecosystems. Using experimental evolution, we demonstrate that ciliates can quickly adapt to tolerate high salinities, but this adaptation may come at a cost to survival in the absence of salt.
Rebecca A. Zufall +3 more
wiley +1 more source