Results 101 to 110 of about 6,597,635 (260)

Targeting the DNA Damage Response in Cancer

MedComm, Volume 7, Issue 10, October 2026.
Targeting the DNA damage response (DDR) reshapes both tumor vulnerability and antitumor immunity. DNA lesions and DDR inhibitors can promote cytosolic nucleic‐acid sensing, antigen presentation, and immune activation, but can also induce adaptive immune escape.
Yihuan Qiao, Boyu Kang, Jian Zhang, Rui Zhang, Jipeng Li   +4 more
wiley   +1 more source

Application of image-recognition techniques to automated micronucleus detection in the in vitro micronucleus assay

Genes and Environment
Background An in vitro micronucleus assay is a standard genotoxicity test. Although the technique and interpretation of the results are simple, manual counting of the total and micronucleus-containing cells in a microscopic field is tedious.
Hiromi Yoda, Kazuya Abe, Hideya Takeo, Takeji Takamura-Enya, Ayumi Koike-Takeshita   +4 more
doaj   +1 more source

Preclinical and Toxicology Studies of LPM7100328, a Novel Oral GnRH Antagonist

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
ABSTRACT LPM7100328 is a novel oral GnRH antagonist being developed for the prevention of premature luteinizing hormone (LH) surges in women undergoing controlled ovarian stimulation. The studies presented herein reported assessment of safety in favor of human clinical trials.
Yao Wang, Junxian Zhao, Fangxia Zou, Wanglin Jiang, Jianzhao Zhang, Pengfei Yu, Liang Ye, Xiaolin Sun, Chunmei Li, Jingwei Tian   +9 more
wiley   +1 more source

PCS-Q-G. Parental Caregiving Style Questionnaire – German Version

Der PCS-Q-G dient der retrospektiven Erfassung des elterlichen Fürsorgeverhaltens. In Analogie zum 3-Kategorien-Modell von Bindung unterscheidet das Instrument zwischen den drei Stilen „warm/aufmerksam“, „ambivalent/inkonsistent“ und „kalt/abweisend ...
Rohmann, E., Neumann, E.
core   +1 more source

Untreated Hair Dye Effluents Enter the Environment: Are They a Threat to Human Health?

Environmental Toxicology, Volume 41, Issue 10, Page 998-1010, October 2026.
ABSTRACT The effluents generated during the process of hair dyeing exhibit a complex composition, comprising chemical compounds with varying toxicity levels. While the adverse impact of hair dyes on human health is acknowledged, there is a notable absence of studies addressing the toxicity associated with effluents produced during these activities. The
Letícia Cristina Gonçalves, Matheus Mantuanelli Roberto, Adriana Fabiana Corrêa da Silva, Maria Aparecida Marin‐Morales   +3 more
wiley   +1 more source

Development of a micronucleus test using the EpiAirway™ organotypic human airway model. [PDF]

Genes Environ, 2023
Munakata S, Watanabe T, Takahashi T, Kimuro S, Ishimori K, Hashizume T.   +5 more
europepmc   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, Volume 20, Issue 9, Page 2135-2162, September 2026.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

STARC-5. Fragebogen für Empowerment und Resilienz

STARC-5 eignet sich mit 5 analytisch entwickelten Dimensionen (Self-esteem/ Selbstvertrauen, Trust/Optimismus, Affective resilience/Affektive Resilienz, Reliable problem solving/Problemlösekompetenz, Cognitive strength/Kognitive Stärke) und insgesamt 39 ...
Himmer-Gurdan, S. B.
core   +1 more source

TME/NIR Dual‐Responsive Zinc‐Based Targeted Nanoagonist for Multimodal Amplification of STING‐Mediated Cancer Immunotherapy

Advanced Science, Volume 13, Issue 49, 3 September 2026.
A multifunctional nanoagonist (cDZ@IP) enables nano‐metabolite–driven multimodal activation of the STING pathway and enhanced immune recognition, achieving potent antitumor immunity and suppressing tumor growth and metastasis. This strategy highlights the rational design of therapeutic metabolites and establishes a new paradigm bridging nanomedicine ...
Kepeng Hu, Jiawei Wang, Wei Zhang, Zhixuan Wu, Jing Chen, Yujing He, Xiyue Duan, Yaoting He, Xin Xin, Haoyi Xiang, Yijing Wang, Chengwei Wu, Yang Yi, Qing Meng, Yuqian Qiao, Kui Cheng, Xiaojun Long, Zhangfa Song   +17 more
wiley   +1 more source

Reply to the opinion paper: is micronucleus test a suitable method for monitoring oral mucosa exposed to dental bleachings in smokers? [PDF]

Arch Toxicol, 2023
Silva RR, De Carli JP, Collares K, Vanini J, Presotto JS, Vargas JE, Loguercio AD, Benetti P.   +7 more
europepmc   +1 more source