Results 91 to 100 of about 6,895,334 (230)

Antimutagenic effect of resveratrol

Czech Journal of Food Sciences, 2005
Evidence exists from population-based and laboratory studies that some phytochemicals have protective effects against tumors or other diseases and reveal antimutagenic activity.
Martina Langová, Zdeňka Polívková, Petr Šmerák, Jiřina Bártová, Ivo Bárta   +4 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, Volume 20, Issue 11, Page 2839-2859, November 2026.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

In vivo and in vitro genotoxicity of N-nitrosopyrrolidine following UVA irradiation

Genes and Environment
N-nitrosopyrrolidine (NPYR) is a volatile nitrosamine that is thought to be a human carcinogen. It is found in air, wastewater, food, and feed. Photo-activation of NPYR can occur as it drifts through the environment.
Yusuke Hanaki, Sakae Arimoto-Kobayashi
doaj   +1 more source

Ferroportin deficiency drives olaparib resistance in ovarian cancer via the cGAS–STING–STAT3 survival axis

Clinical and Translational Medicine, Volume 16, Issue 11, November 2026.
Abstract Background Ovarian cancer (OC) remains the most lethal gynaecological malignancy, and acquired resistance to PARP inhibitors such as olaparib represents a major clinical challenge. Although dysregulation of iron metabolism has been implicated in tumorigenesis, the specific role of the iron exporter SLC40A1 (ferroportin, FPN) in mediating ...
Jiagui Song, Zhengyang Guo, Decao Yang, Ping Yu, Yinjia Li, Zhuhui Yuan, Xiaojuan Ma, Xianlong Li, Hongyan Guo, Lixiang Xue, Tong Liu   +10 more
wiley   +1 more source

Safety Assessment and Hypoglycemic Effect of Moringa oleifera Lam. Seed Lectin (WSMoL) in Alloxan‐Induced Diabetic Mice

Journal of Applied Toxicology, Volume 46, Issue 11, Page 3973-3988, November 2026.
ABSTRACT Moringa oleifera Lam. seeds contain WSMoL, a lectin previously studied for toxicity and pharmacological effects. In this study, we investigated WSMoL (10, 25, or 50 mg/kg i.p.) for acute and 14‐day repeated‐dose toxicity, as well as genotoxicity, in Swiss mice.
Alícia Natalie Silva dos Santos, Matheus Cavalcanti de Barros, Cleidiane Silva Vieira de Souza, Ryan Cristian da Silva, Luana Cassandra Breitenbach Barroso Coelho, Maria Tereza dos Santos Correia, Fernanda das Chagas Ângelo Mendes Tenório, Alisson Macário de Oliveira, Thiago Henrique Napoleão, Robson Raion de Vasconcelos Alves, Patrícia Maria Guedes Paiva   +10 more
wiley   +1 more source

Characterization and genotoxicity evaluation of effluent from a pharmacy industry

Revista Ambiente & Água, 2013
The pharmaceutical, textile and food industry bear much of the responsibility for environmental pollution. In order to appropriately treat and mitigate the effects of pharmaceutical effluent, it is necessary to study it in order to determine its physical
Hélio Mendes de Oliveira Júnior, Paulo de Tarso Ferreira Sales, Danyllo Bueno de Oliveira, Fernando Schimidt, Mariângela Fontes Santiago, Luiza Cintra Campos   +5 more
doaj   +1 more source

Bisphenol A Induces DNA Damage and Differential Cytotoxicity in Thyroid Cells: High‐Dose Effects Challenge Regulatory Thresholds

Journal of Applied Toxicology, Volume 46, Issue 11, Page 3882-3892, November 2026.
ABSTRACT Bisphenol A (BPA), a ubiquitous environmental endocrine disruptor, has been implicated in carcinogenesis; however, its effects on thyroid cells remain unclear. This study investigated BPA‐induced cytotoxicity and genotoxicity in thyroid cell lines, including normal follicular (Nthy‐ori 3‐1), papillary carcinoma (TPC‐1 and BCPAP) and anaplastic
Izabela Fernanda Dal' Bó, Natássia Elena Bufalo, Valdemar Máximo, Laura Sterian Ward   +3 more
wiley   +1 more source

Hen's egg test for micronucleus induction (HET-MN) [PDF]

, 2016
Genotoksisite testleri içinde çok yaygın kullanılan yöntemlerden biri mikronükleus tekniğidir. Mikronükleus testleri içerisinde ise diğerlerine kıyasla daha yeni bir teknik Tavuk Yumurtası Mikronükleus Testi (Hen's Egg Test for Micronucleus ...
Çelık, Bülent, Özparlak, Haluk
core  

Evaluation of DNA/Chromosome Integrity and Cell Death in Human Metabolically Noncompetent and Competent Cells Exposed to N′‐(3,5‐Difluorobenzylidene)Pyridine‐4‐Carbohydrazide

Journal of Applied Toxicology, Volume 46, Issue 11, Page 4076-4084, November 2026.
ABSTRACT The N‐acylhydrazone scaffold is recognized as a privileged structure for the design of bioactive substances with increasing applications in medicinal chemistry research. Ensuring the safety of newly developed molecules is a critical step for both human health and environmental protection. Accordingly, this study aimed to evaluate the cytotoxic
Larissa Ribeiro Canuto Santos, Jéssica Natalia Barbosa de Almeida, Camila Cavalleiro Frias, Wanda Pereira Almeida, Edson Luis Maistro   +4 more
wiley   +1 more source

Micronucleus Assay for Evaluation of Genotoxicity in Potentially Malignant and Malignant Disorders

Journal of Indian Academy of Oral Medicine and Radiology, 2011
Oral cancer is a common malignancy, ranking first among all cancers in Western and Asian countries. It is preceded by some benign lesions or conditions, which are termed precancerous.
Parvathi Devi, V B Thimmarasa, Vishal Mehrotra, Pallak Arora   +3 more
doaj   +1 more source