Results 121 to 130 of about 15,524 (254)
Genotoxicity profile of fexinidazole—a drug candidate in clinical development for human African trypanomiasis (sleeping sickness) [PDF]
The parasitic disease human African trypanomiasis (HAT), also known as sleeping sickness, is a highly neglected fatal condition endemic in sub-Saharan Africa, which is poorly treated with medicines that are toxic, no longer effective or very difficult to
Bourdin Trunz, Bernadette +2 more
core
ABSTRACT Butylparaben (BuP) recurrently contaminates soils worldwide, mainly by incorporating sewage sludge into cultivated areas, using wastewater in irrigation, and leaching contaminated soils. However, there are few studies on the ecotoxicological effects of this paraben on edaphic organisms.
Lorena Maihury Santos Tsubouchi +13 more
wiley +1 more source
In vitro genotoxicity testing using the micronucleus assay in cell lines, human lymphocytes and 3D human skin models [PDF]
The toxicological relevance of the micronucleus (MN) test is well defined: it is a multi-target genotoxic endpoint, assessing not only clastogenic and aneugenic events but also some epigenetic effects, which is simple to score, accurate, applicable in ...
Aardema, Marilyn J. +5 more
core
Cellular Stress, Inflammation and Barrier Damage in Gut Epithelial Cells Caused by Aspartame
This study shows that aspartame, at dietary‐relevant doses, induces cytotoxicity, cellular distress associated with endoplasmic reticulum stress, oxidative stress, DNA replication and repair mechanism disturbance culminating in epithelial barrier damage.
Yagiz Pat +16 more
wiley +1 more source
Radiography is one of the most valuable diagnostic tools used in comprehensive dental care. Although there is no safe level of radiation exposure, the possible risk associated with exposure to radiation, must be elucidated.
Pallak Arora +2 more
doaj
Some water bodies in the Sinos River Basin (SRB) have been suffering the effects of pollution by residential, industrial and agroindustrial wastewater. The presence of cytotoxic and genotoxic compounds could compromise the water quality and the balance ...
E Bianchi +8 more
doaj +1 more source
Exposures in Indoor Air Affecting Health
ABSTRACT Indoor air quality (IAQ) is influenced by a wide range of chemical, biological and physical agents that can negatively impact physical, immunological and mental health. Adverse health effects depend on the type and concentration of pollutants, duration of exposure, and individual susceptibility.
Maria Hartiala +38 more
wiley +1 more source
Sex Differences in Metabolite–Immune Circuits of Neuroinflammation
ABSTRACT Sex is a fundamental yet underexplored determinant of human neuroinflammation. Across autoimmune, neurodegenerative, and post‐infectious neurological syndromes, males and females exhibit consistent differences in disease vulnerability, progression, and immune tone.
Priyanka Saminathan +6 more
wiley +1 more source
Evaluation of the Genotoxicity of Bangpungtongsung-San, a Traditional Herbal Prescription [PDF]
Bangpungtongsung-san (BPS) is a traditional Korean herbal formula used as an anti-inflammatory, antipyretic, antiobesity, and choleretic agent, which consists of 18 herbs.
In-Sik Shin +6 more
doaj
Abstract This case report presents a recent case of scuticociliatosis in a whitetip reef shark (Triaenodon obesus), housed at a zoo (Haus des Meeres Aqua Terra Zoo, Vienna, Austria). Clinical signs such as uncoordinated swimming and body tilt were observed prior to death.
Hella Schwegler +5 more
wiley +1 more source

