Results 141 to 150 of about 7,624 (203)

Dual E-Cigarette Users Show Nicotine Addiction Risk Alleles and Nuclear Abnormalities in Oral Epithelial Cells. [PDF]

Adv Respir Med
Montero-Ruiz O, Falfán-Valencia R, Buendía-Roldán I, Valencia-Pérez Rea D, Rueda-Munive GE, Fricke-Galindo I, García-Carmona S, Abarca-Rojano E, Pérez-Rubio G.   +8 more
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Systematic biocompatibility assessment of 4-µm surface silicone implants. [PDF]

Biomater Biosyst
Mora-Leiva I, Mack CM, Clausen-Oreamuno C, Elizondo Hidalgo Y, Zamora-Mora V, Villalobos A, Zoncsich A, Munhoz AM, Sforza M, De Mezerville R.   +9 more
europepmc   +1 more source

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The micronucleus test

Mutation Research - Environmental Mutagenesis and Related Subjects Including Methodology, 1975
The micronucleus test (m.t.) in vivo is a method devised primarily for screening chemicals for chromosome-breaking effects. The test substances are normally applied sub-acutely to small mammals, and the effect is read in direct smears from bone marrow. This testing procedure, developed by SCHMID and coworkers1~3~5~6 has a number of important advantages
exaly   +3 more sources

The micronucleus test in piscine erythrocytes

Aquatic Toxicology, 2006
Cytogenetic assays on aquatic organisms are essential, as humans are exposed throughout their lifetime to several xenobiotics present in both the water and aquatic food. The micronucleus test showed to be a useful in vivo assay for genotoxicity testing. However, many aspects of its protocol need to be refined, knowledge of confounding factors should be
Ion Udroiu
exaly   +3 more sources

Sampling times in micronucleus testing

Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis, 1992
A series of micronucleus inducers were evaluated in the mouse bone marrow micronucleus test to determine if a 72-h sampling time enhances the sensitivity for detecting genotoxic agents. Male and female Swiss albino mice were dosed once with 7,12- dimethylbenz[a]anthracene, 6-mercaptopurine, benzo[a]pyrene, benzene, cyclophosphamide, 2 ...
Philippe Vanparys
exaly   +3 more sources

The effect of benzene in the micronucleus test

Mutation Research/Genetic Toxicology, 1980
The potential cytogenetic effect of benzene was studied by means of the micronucleus test in developing erythrocytes of male and female mice at dosages ranging from 0.0625 to 2.0 ml/kg/day. Groups of mice were given two daily oral doses and sacrificed 6, 18, 24 or 48 h, or 5, 9 or 16 days after the last dose. The doses were given 24 h apart.
M, Hite, M, Pecharo, I, Smith, S, Thornton   +3 more
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Effect of erythropoietin on the micronucleus test

Environmental and Molecular Mutagenesis, 1989
AbstractThe micronucleus test is used widely as an in vivo short‐term assay for potential carcinogens. In the present study, results of the micronucleus test were affected by the rate of erythropoiesis in the bone marrow erythropoietin, a growth factor for the erythroblast, which was used to induce erythropoiesis.The highest frequency of micronucleated
Y, Suzuki, Y, Nagae, T, Ishikawa, Y, Watanabe, T, Nagashima, K, Matsukubo, H, Shimizu   +6 more
openaire   +2 more sources

Statistical analysis of the micronucleus test

Mutation Research, 1984
Various statistical procedures are discussed to compare the incidence of micronucleated polychromatic erythrocytes between various treatment groups and a negative control. The effect of toxicity on the choice of statistical procedure is discussed. The procedure which is recommended is based on likelihood ratio tests comparing each dose group separately
G E, Amphlett, G F, Delow
openaire   +2 more sources

The micronucleus test methodological aspects

Mutation Research, 1973
Changes in the cellular compositiion of bone marrow were studied in relation to dose of Trenimon® and time after treatment. Strong mutagenic effects caused a partial depletion of the marrow cavities of nucleated blood cell precursors, with subsequent retention of newly formed erythrocytes and inundation with peripheral blood.
Von Ledebur, M, Schmid, Werner
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