Results 131 to 140 of about 24,556,719 (242)

Microphysiological systems [PDF]

APL Bioengineering, 2019
James J. Hickman, Dongeun Huh, Roger D. Kamm   +2 more
openaire   +3 more sources

Mechanical stimulation and monitoring of artificial collagen membranes for Organ-on Chip applications

Current Directions in Biomedical Engineering
A novel tool to create artificial, cell-based model systems of biological barriers for preclinical drug testing and basic research are artificial collagen membranes (ACM).
Behrens Stephan, Golde Jonas, Schöps Yvo, Polk Christoph, Seidel Gloria, Goerke Felix, Sonntag Frank, Schmieder Florian   +7 more
doaj   +1 more source

Collagen concentration regulates neutrophil extravasation and migration in response to infection in an endothelium dependent manner

Frontiers in Immunology
IntroductionAs the body’s first line of defense against disease and infection, neutrophils must efficiently navigate to sites of inflammation; however, neutrophil dysregulation contributes to the pathogenesis of numerous diseases that leave people ...
Christopher J. Calo, Tanvi Patil, Mallory Palizzi, Nicola Wheeler, Laurel E. Hind   +4 more
doaj   +1 more source

DB-ALM Report, 2016 [PDF]

, 2016
This deliverable report outlines the activities performed during January 2014-June 2016 for the DB-ALM (EURL ECVAM DataBase service on advanced and Alternative Methods) enhancements regarding: information content, system evolution and innovation, as well
COE ANTHONY, FLEGO Manuela, JANUSCH ROI Annett, SWIATEK AGNIESZKA LIDIA   +3 more
core   +1 more source

A microphysiological system reveals neutrophil contact-dependent attenuation of pancreatic tumor progression by CXCR2 inhibition-based immunotherapy

Scientific Reports
Cancer cells recruit neutrophils from the bloodstream into the tumor tissue, where these immune cells promote the progression of numerous solid tumors.
Shuai Shao, N. Delk, Caroline N Jones
semanticscholar   +1 more source

Pediatric Developmental Safety Assessment: Are We Ready for the Next Thalidomide?

Clinical Pharmacology &Therapeutics, EarlyView.
Pediatric drug development has achieved remarkable success in the last 20 years with over 1,000 products studied in pediatric patients. This success has been driven in part by an increased understanding of pediatric disease processes. The aspect that has been largely overlooked is the potential adverse effect of new drugs on pediatric developmental ...
Gilbert J. Burckart, Susan M. Abdel‐Rahman, Gelareh Abulwerdi, Sherbet Samuels, Rebecca Racz, Mohamed A. Mohamoud, Nicholas P. Tatonetti   +6 more
wiley   +1 more source

Potential value of animal microphysiological systems

ALTEX
Microphysiological systems (MPS) are designed to recapitulate aspects of tissue/organ physiology in vivo, thereby providing potential value in safety and efficacy assessments of FDA-regulated products and regulatory decision-making. While there have been significant advances in the development, use, and proposals of qualification criteria for human ...
Paul C, Brown, Barry H, Hooberman, Brianna L, Skinner, Claudia, Wrzesinski, Dayton M, Petibone, Kevin A, Ford, Kristi, Muldoon-Jacobs, Kyung E, Sung, Luis G, Valerio, Nakissa N, Sadrieh, Paul C, Howard, Peter L, Goering, Shelby A, Skoog, Suzanne C, Fitzpatrick, Tracy, Chen, Tracy C, MacGill, Donna L, Mendrick   +16 more
openaire   +2 more sources

A path forward advancing microphysiological systems

ALTEX
Microphysiological systems (MPS), including organ-on-chip platforms and complex organoid models, represent a transformative approach to human-relevant in vitro modeling. These technol-ogies bioengineer aspects of organ architecture and functionality, revolutionizing drug development, reducing animal testing, and enabling personalized medicine ...
Thomas, Hartung, Lena, Smirnova
openaire   +2 more sources

Systems toxicology: real world applications and opportunities [PDF]

, 2017
Systems Toxicology aims to change the basis of how adverse biological effects of xenobiotics are characterized from empirical end points to describing modes of action as adverse outcome pathways and perturbed networks. Toward this aim, Systems Toxicology
Amin Rostami-Hodjegan, Coecke S., Gary R. Mirams, Hartung T., Imran Shah, Manuel C. Peitsch, Martin F. Wilks, National Institute of Environmental Health Sciences, OECD, Paul Jennings, Rex E. FitzGerald, Shana J. Sturla, Thomas Hartung, van Vliet E., Wilmes A.   +14 more
core   +2 more sources

Assessing immune hepatotoxicity of troglitazone with a versatile liver-immune-microphysiological-system

Frontiers in Pharmacology
Drug-induced liver injury is a prevalent adverse event associated with pharmaceutical agents. More significantly, there are certain drugs that present severe hepatotoxicity only during the clinical phase, consequently leading to the termination of drug ...
Quanfeng Deng, Youlong Yang, Yuangui Liu, Mengting Zou, Guiyuan Huang, Shiqi Yang, Lingyu Li, Yueyang Qu, Yong Luo, Xiuli Zhang   +9 more
semanticscholar   +1 more source