Results 121 to 130 of about 24,554,140 (185)

Rescue of impaired blood-brain barrier in tuberous sclerosis complex patient derived neurovascular unit

Journal of Neurodevelopmental Disorders
Background Tuberous sclerosis complex (TSC) is a multi-system genetic disease that causes benign tumors in the brain and other vital organs. The most debilitating symptoms result from involvement of the central nervous system and lead to a multitude of ...
Jacquelyn A. Brown, Shannon L. Faley, Monika Judge, Patricia Ward, Rebecca A. Ihrie, Robert Carson, Laura Armstrong, Mustafa Sahin, John P. Wikswo, Kevin C. Ess, M. Diana Neely   +10 more
doaj   +1 more source

Molecular Glue Degraders Redefining Targeted Therapies From Discovery to Therapeutic Applications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Molecular glue degraders (MGDs) constitute an emerging class of therapeutic agents poised to revolutionize the paradigm of targeted drug discovery. By reprogramming E3 ubiquitin ligases to degrade proteins of interest (POI) via a transient formation of a ternary complex mediated by protein–protein interactions, MGDs surpass the intrinsic limitations of
Jinfeng Wen, Jingtian Yu, Wuqiang Wen, Baishan Jiang   +3 more
wiley   +1 more source

Microphysiological Systems for Cancer Immunotherapy Research and Development. [PDF]

Adv Biol (Weinh), 2023
AbstractCancer immunotherapy focuses on the use of patients’ adaptive immune systems to combat cancer. In the past decade, FDA has approved many immunotherapy products for cancer patients who suffer from primary tumors, tumor relapse, and metastases. However, these immunotherapies still show resistance in many patients and often lead to inconsistent ...
Peng Y, Lee E.
europepmc   +3 more sources

Emergence, Challenges, and Opportunities for Chiral Nanocellulose Assemblies in Tissue Engineering and Wound Healing

Small Structures, Volume 7, Issue 3, March 2026.
This review explores chiral nanomaterials for tissue engineering and wound healing, specifically focusing on the potential of nanocellulose. The inherent chirality of nanocelluloses and their assemblies enables the creation of biomimetic scaffolds with unique biological interactions. Chiral nematic self‐assembly of cellulose nanocrystals, in particular,
Mahboubeh Nabavinia, Hossein Khanjanzadeh, Asier R. Muguruza, Anna Roig, Erlantz Lizundia, Justin O. Zoppe   +5 more
wiley   +1 more source

An eighteen-organ microphysiological system coupling a vascular network and excretion system for drug discovery

Microsystems & Nanoengineering
Physiological supporting systems, such as the vascular network and excretion system, are crucial for the effective functioning of organs. This study demonstrates that when a body-on-a-chip microdevice is coupled with miniaturized physiological support ...
Jing Wang, Huixue Zhang, Yueyang Qu, Yang Yang, Shuhui Xu, Zhenni Ji, Yuxiu Wang, Xiuli Zhang, Yong Luo   +8 more
doaj   +1 more source

Opportunities and challenges for human microphysiological systems in drug development.

ALTEX
Microphysiological systems (MPS) are complex in vitro tools that incorporate cells derived from various healthy or disease-state human or animal tissues and organs.
Shekh M Rahman, A. Krishna, Catherine Sullenberger, Ye Eun Jeong, M. I. Garcia, Bhavya Bhardwaj, Robert M. Geiger, Ksenia Blinova, Kevin A Ford   +8 more
semanticscholar   +1 more source

Moving lab-grown tissues into the clinic: organ-on-a-chip and bioengineered skin systems

Frontiers in Lab on a Chip Technologies
For patients with end stage organ failure, organ transplant is frequently the only curative option available. However, organs available for transplant are in critically short supply around the world, which has led to lengthy wait times and increased ...
Catherine A. Reed-McBain, Catherine A. Reed-McBain, Janmesh D. Patel, Finnbar L. K. Reed-McBain, David Al-Adra, María Virumbrales-Muñoz, María Virumbrales-Muñoz, María Virumbrales-Muñoz, Jose M. Ayuso, Jose M. Ayuso, Jose M. Ayuso   +10 more
doaj   +1 more source

Development of intestinal organoids and microphysiological systems and their application to drug discovery.

Drug Metabolism and Pharmacokinetics
The intestines are an important organ with a variety of functions. For drug discovery research, experimental animals and Caco-2 cells derived from a human colon carcinoma may be used to evaluate the absorption and safety of orally administered drugs ...
Takahiro Iwao, Tamihide Matsunaga
semanticscholar   +1 more source

Human in vitro endometriosis microphysiological system

Current Directions in Biomedical Engineering
Abstract Endometriosis is a debilitating condition that causes severe pain and infertility, among other morbidities. It affects 10% of reproductive-aged women worldwide and poses a significant public health challenge due to its prevalence and the lack of effective treatments and diagnostic tools.
Joao Pinheiro Marques, Nastasia Verdes, Laetitia Nikles, Vincent Mendes Ferreira, Shaginth Sivakumar, Adrien Roux   +5 more
openaire   +1 more source

Personalized Vascularized Models of Breast Cancer Desmoplasia Reveal Biomechanical Determinants of Drug Delivery to the Tumor

Advanced Science
Desmoplasia in breast cancer leads to heterogeneity in physical properties of the tissue, resulting in disparities in drug delivery and treatment efficacy among patients, thus contributing to high disease mortality.
Giovanni S. Offeddu, Elena Cambria, Sarah E. Shelton, Kristina Haase, Zhengpeng Wan, Luca Possenti, Huu Tuan Nguyen, Mark R. Gillrie, Dean Hickman, Charles G. Knutson, Roger D. Kamm   +10 more
doaj   +1 more source