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Application of microphysiological systems in biopharmaceutical research and development
Lab on a Chip, 2020In this review, we describe some of the advances made for tissue-specific microphysiological systems and outline the advantages and challenges of applying and further developing MPS technology in preclinical biopharmaceutical research.
Norman C. Peterson +3 more
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Microphysiological systems inspired by leaf venation
Trends in BiotechnologyNature-inspired microfluidic networks are revolutionizing microphysiological systems, allowing for the precise emulation of human physiology. This article delves into the fabrication techniques of leaf-venation-inspired (LVI) microfluidic networks and explores their transformative applications in organ-on-a-chip and tissue engineering, showcasing their
Mao Mao +3 more
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Biologically-Inspired Microphysiological Systems
2019Microphysiological multi-organ devices are designed to mimic the physiological interaction of various interconnected organ models, by successfully imitating organismal functionality and response to substances. The first concepts of in vitro multi-organ systems were put forward in the late 1980s, demonstrating that such systems could provide mechanistic
Dehne, Eva Maria +2 more
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Microphysiological Systems: A Cellular Dilemma
2021Presentation to the Microphysiological Systems (MPS) Webinar: Bridging Human and Animal Research January ...
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The potential of neural microphysiological systems (MPS)
Folia Pharmacologica JaponicaIn vitro compound evaluation using human-derived neural cells is beginning to incorporate microphysiological systems (MPS). Neural MPS includes not only microfluidic devices but has also recently recognized neural organoids as viable MPS platforms. The history of neural MPS utilizing microfluidic devices is extensive, with the development of models ...
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Microphysiological Models of the Respiratory System
2019The lung is an essential organ that shows remarkable complexity in its structure, environment, and function. Mimicking this dynamic and complex organ in experimental model systems remains a major challenge in biomedical research. Here we review recent research efforts directed towards leveraging microfluidic cell culture techniques to develop ...
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Recent Advances in Microfluidic-Based Microphysiological Systems
Biochip Journal, 2021Sung-Min Kang
exaly
Assessment of the toxicity of acrolein on an alveolus microphysiological system
Environmental Toxicology and PharmacologyWith the advancement of industrialization, public concerns about air pollution have been increasing. As the primary site of gas exchange in the respiratory system, the human lung is highly susceptible to the toxic effects of environmental pollutants.
Yanfei, Xu +3 more
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