Results 1 to 10 of about 491,214 (210)

Mesenchymal stem cell-derived exosome-educated macrophages alleviate systemic lupus erythematosus by promoting efferocytosis and recruitment of IL-17+ regulatory T cell

Stem Cell Research & Therapy, 2022
Background Anti-inflammatory polarized macrophages are reported to alleviate systemic lupus erythematosus (SLE). Our previous studies have demonstrated that exosomes from adipose-derived stem cells promote the anti-inflammatory polarization of ...
Mingchao Zhang, Takerra K. Johnson-Stephenson, Weiran Wang, Yang Wang, Jing Li, Limin Li, Ke Zen, Xi Chen, Dihan Zhu   +8 more
doaj   +1 more source

Urinary MicroRNA Profiling in the Nephropathy of Type 1 Diabetes [PDF]

, 2013
Background: Patients with Type 1 Diabetes (T1D) are particularly vulnerable to development of Diabetic nephropathy (DN) leading to End Stage Renal Disease.
A Krupa, A Micera, Analysis The Case for Objective Bayesian, AO Phillips, B John, Christos Argyropoulos, D Lunn, D Macconi, D Shan, David Galas, David Huang, Demetrius Ellis, DP Bartel, G Ghosh, G Togliatto, G Wang, G Wang, G Wang, H Guo, H Haller, H Sun, J Hou, JA Weber, JM Lorenzen, John Johnson, Jose Bernardo, K Bhatt, K Heese, K Sharma, Kai Wang, Karin Jandeleit-Dahm, L Denby, L Held, L Mahimainathan, L Matthews, M Ashburner, M Hackl, M Kato, M Kato, M Kato, ME Molitch, MW Pfaffl, O García-Sánchez, P Dentelli, P Kantharidis, P Ruggenenti, PE Pergola, R Bonofiglio, R Liao, RC Friedman, RC Gentleman, RC Lee, RW Carthew, S Fatima, Sara McClarty, SM Titan, SW Shan, T Roweis, Sam, TD Schmittgen, Trevor Orchard, U Tran, VA Valera, W Stacklies, X Wang, X-Y Bai, Y Dai, YS Kanwar, Z Chun-Zhi   +67 more
core   +11 more sources

Polynucleotide phosphorylase protects against renal tubular injury via blocking mt-dsRNA-PKR-eIF2α axis

Nature Communications, 2023
Renal tubular atrophy is a hallmark of chronic kidney disease. The study by Zhu et al. reveals the protective role of tubular polynucleotide phosphorylase (PNPT1) against renal atrophy by blocking the leakage of mitochondrial dsRNAs into cytoplasm where ...
Yujie Zhu, Mingchao Zhang, Weiran Wang, Shuang Qu, Minghui Liu, Weiwei Rong, Wenwen Yang, Hongwei Liang, Caihong Zeng, Xiaodong Zhu, Limin Li, Zhihong Liu, Ke Zen   +12 more
doaj   +1 more source

Secreted miRNAs in the tripartite neuromuscular junction

ExRNA, 2019
microRNAs are small, non-coding, single-stranded RNAs that can suppress mRNA translation at the posttranscriptional level by binding to imperfect complementary sequences on mRNA targets and then cause their degradation or hinder protein translation ...
Liangsheng Lu, Yuan Liu, Yuyan Liu, Fan Zhang, Han Wang, Qipeng Zhang, Feng Pan   +6 more
doaj   +1 more source

Clusters of microRNAs emerge by new hairpins in existing transcripts [PDF]

, 2013
Genetic linkage may result in the expression of multiple products from a polycistronic transcript, under the control of a single promoter. In animals, protein-coding polycistronic transcripts are rare.
Alberts, Altschul, Altuvia, Antonio Marco, Aravin, Auyeung, Axtell, Bartel, Bartel, Barton, Baskerville, Blumenthal, Blumenthal, Boutla, Campo-Paysaa, Charlesworth, Cutter, Felsenstein, Griffiths-Jones, Griffiths-Jones, Grimson, Han, Hertel, Hill, Katoh, Kim, Kloosterman, Kozomara, Krol, Lagos-Quintana, Larkin, Lau, Lawrence, Leaman, Lee, Lee, Li, Lynch, Lynch, Maher, Marco, Marco, Marco, Marco, Marco, Maria Ninova, Matthew Ronshaugen, Maynard Smith, Nozawa, Nozawa, Qian, Roux, Ruby, Ryazansky, Saini, Saini, Saitou, Salgado, Sam Griffiths-Jones, Satou, Savard, Sempere, Tamura, Tanzer, Wheeler, Wheeler, Zeng   +66 more
core   +2 more sources

Initial function of microRNAs as a defence mechanism against invading organisms

ExRNA, 2019
Background Although microRNA (miRNA) regulation is widely considered as a mechanism to regulate gene expression in metazoans, plants and viruses, there are recent reports that show the interaction between viruses and their mammal hosts via miRNAs ...
Xiaoshuang Liu, Xinyuan Zang, Helian Feng, Quan Zhao, Chenyu Zhang, Jin Wang   +5 more
doaj   +1 more source

Downregulation of plasma MiR-142-3p and MiR-26a-5p in patients with colorectal carcinoma [PDF]

, 2015
Background: Colorectal cancer is one of the most commonly diagnosed cancers and cancer- related death worldwide. Identification of new specific biomarkers could be helpful to detection of this malignancy.
Asadi, J., Ghanbari, R., Knuutila, S., Malekzadeh, R., Mohamadkhani, A., Mosakhani, N., Mowla, S.J., Nouraee, N., Poustchi, H., Yazdani, Y.   +9 more
core   +1 more source

Tumor-specific delivery of KRAS siRNA with iRGD-exosomes efficiently inhibits tumor growth

ExRNA, 2019
Lung cancer is the major cause of cancer-related deaths globally. Mutant KRAS is a feature of 15–50% of lung cancer cases and represents one of the most prevalent oncogenic drivers in this disease.
Yu Zhou, Yuan Yuan, Minghui Liu, Xiuting Hu, Yiming Quan, Xi Chen   +5 more
doaj   +1 more source

In vivo self-assembled siRNA as a modality for combination therapy of ulcerative colitis

Nature Communications, 2022
Management of ulcerative colitis can require a combination of treatments targeting different pathways. Here the authors design a therapy for ulcerative colitis based on a multitargeted genetic circuit to simultaneously target TNF-α, B7-1 and integrin α4,
Xinyan Zhou, Mengchao Yu, Luzhen Ma, Jinyu Fu, Jingwei Guo, Jieqiong Lei, Zheng Fu, Yong Fu, Qipeng Zhang, Chen-Yu Zhang, Xi Chen   +10 more
doaj   +1 more source

MicroRNA-222 regulates muscle alternative splicing through Rbm24 during differentiation of skeletal muscle cells [PDF]

, 2016
A number of microRNAs have been shown to regulate skeletal muscle development and differentiation. MicroRNA-222 is downregulated during myogenic differentiation and its overexpression leads to alteration of muscle differentiation process and specialized ...
Cappella, Marisa, Cardinali, B., Cittaro, D., Falcone, G., Garcia Manteiga, J. M., Lazarevic, D., Martelli, F, Provenzano, C.   +7 more
core   +2 more sources