Results 1 to 10 of about 281,876 (175)

Mesenchymal stem cell-derived exosome-educated macrophages alleviate systemic lupus erythematosus by promoting efferocytosis and recruitment of IL-17+ regulatory T cell

Stem Cell Research & Therapy, 2022
Background Anti-inflammatory polarized macrophages are reported to alleviate systemic lupus erythematosus (SLE). Our previous studies have demonstrated that exosomes from adipose-derived stem cells promote the anti-inflammatory polarization of ...
Mingchao Zhang, Takerra K. Johnson-Stephenson, Weiran Wang, Yang Wang, Jing Li, Limin Li, Ke Zen, Xi Chen, Dihan Zhu   +8 more
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Polynucleotide phosphorylase protects against renal tubular injury via blocking mt-dsRNA-PKR-eIF2α axis

Nature Communications, 2023
Renal tubular atrophy is a hallmark of chronic kidney disease. The study by Zhu et al. reveals the protective role of tubular polynucleotide phosphorylase (PNPT1) against renal atrophy by blocking the leakage of mitochondrial dsRNAs into cytoplasm where ...
Yujie Zhu, Mingchao Zhang, Weiran Wang, Shuang Qu, Minghui Liu, Weiwei Rong, Wenwen Yang, Hongwei Liang, Caihong Zeng, Xiaodong Zhu, Limin Li, Zhihong Liu, Ke Zen   +12 more
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In vivo self-assembled siRNA as a modality for combination therapy of ulcerative colitis

Nature Communications, 2022
Management of ulcerative colitis can require a combination of treatments targeting different pathways. Here the authors design a therapy for ulcerative colitis based on a multitargeted genetic circuit to simultaneously target TNF-α, B7-1 and integrin α4,
Xinyan Zhou, Mengchao Yu, Luzhen Ma, Jinyu Fu, Jingwei Guo, Jieqiong Lei, Zheng Fu, Yong Fu, Qipeng Zhang, Chen-Yu Zhang, Xi Chen   +10 more
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Serum microRNA Profiles Serve as Novel Biomarkers for Autoimmune Diseases

Frontiers in Immunology, 2018
Autoimmune diseases involve a complex dysregulation of immunity. Autoimmune diseases include many members [e.g., rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE)], and most of them are classified according to what organs and tissues are ...
Fangfang Jin, Huanhuan Hu, Ming Xu, Shoubin Zhan, Yanbo Wang, Huayong Zhang, Xi Chen   +6 more
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ALOX5 deficiency contributes to bladder cancer progression by mediating ferroptosis escape

Cell Death and Disease, 2023
Ferroptosis is an iron-dependent form of regulated cell death driven by the lethal lipid peroxides. Previous studies have demonstrated that inducing ferroptosis holds great potential in cancer therapy, especially for patients with traditional therapy ...
Tianyao Liu, Xinyan Xu, Jiazheng Li, Ming Bai, Wenjie Zhu, Yanqing Liu, Siyang Liu, Zihan Zhao, Tianhang Li, Ning Jiang, Yuhao Bai, Qingyang Jin, Yulin Zhang, Yufeng Zheng, Shengkai Zhou, Shoubin Zhan, Ying Sun, Gaoli Liang, Yang Luo, Xi Chen, Hongqian Guo, Rong Yang   +21 more
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Shikonin Inhibits the Proliferation of Human Breast Cancer Cells by Reducing Tumor-Derived Exosomes

Molecules, 2016
Shikonin is a naphthoquinone isolated from the traditional Chinese medicine Lithospermum. It has been used in the treatment of various tumors. However, the effects of shikonin on such diseases have not been fully elucidated.
Yao Wei, Mingzhen Li, Shufang Cui, Dong Wang, Chen-Yu Zhang, Ke Zen, Limin Li   +6 more
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Characterization of an Aplysia vasotocin signaling system and actions of posttranslational modifications and individual residues of the ligand on receptor activity

Frontiers in Pharmacology, 2023
The vasopressin/oxytocin signaling system is present in both protostomes and deuterostomes and plays various physiological roles. Although there were reports for both vasopressin-like peptides and receptors in mollusc Lymnaea and Octopus, no precursor or
Ju-Ping Xu, Xue-Ying Ding, Shi-Qi Guo, Hui-Ying Wang, Wei-Jia Liu, Hui-Min Jiang, Ya-Dong Li, Ping Fu, Ping Chen, Yu-Shuo Mei, Guo Zhang, Hai-Bo Zhou, Hai-Bo Zhou, Jian Jing, Jian Jing, Jian Jing   +15 more
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Predicting MicroRNA Mediated Gene Regulation between Human and Viruses

Cells, 2018
MicroRNAs (miRNAs) mediate various biological processes by actively fine-tuning gene expression at the post-transcriptional level. With the identification of numerous human and viral miRNAs, growing evidence has indicated a common role of miRNAs in ...
Xin Shu, Xinyuan Zang, Xiaoshuang Liu, Jie Yang, Jin Wang   +4 more
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Pyruvate kinase type M2 promotes tumour cell exosome release via phosphorylating synaptosome-associated protein 23

Nature Communications, 2017
Exosomes, vesicles secreted by cancer cells, have a role in cancer progression but the mechanisms regulating their biogenesis are mostly unknown. Here the authors show that PKM2, a rate-limiting glycolytic enzyme overexpressed in cancer cells, mediates ...
Yao Wei, Dong Wang, Fangfang Jin, Zhen Bian, Limin Li, Hongwei Liang, Mingzhen Li, Lei Shi, Chaoyun Pan, Dihan Zhu, Xi Chen, Gang Hu, Yuan Liu, Chen-Yu Zhang, Ke Zen   +14 more
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Identification of an allatostatin C signaling system in mollusc Aplysia

Scientific Reports, 2022
Neuropeptides, as pervasive intercellular signaling molecules in the CNS, modulate a variety of behavioral systems in both protostomes and deuterostomes.
Hui-Min Jiang, Zhe Yang, Ying-Yu Xue, Hui-Ying Wang, Shi-Qi Guo, Ju-Ping Xu, Ya-Dong Li, Ping Fu, Xue-Ying Ding, Ke Yu, Wei-Jia Liu, Guo Zhang, Jian Wang, Hai-Bo Zhou, Abraham J. Susswein, Jian Jing   +15 more
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