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Stem Cell Research & Therapy, 2022 Background Anti-inflammatory polarized macrophages are reported to alleviate systemic lupus erythematosus (SLE). Our previous studies have demonstrated that exosomes from adipose-derived stem cells promote the anti-inflammatory polarization of ...
Mingchao Zhang +8 more
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Nature Communications, 2023 Renal tubular atrophy is a hallmark of chronic kidney disease. The study by Zhu et al. reveals the protective role of tubular polynucleotide phosphorylase (PNPT1) against renal atrophy by blocking the leakage of mitochondrial dsRNAs into cytoplasm where ...
Yujie Zhu +12 more
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Secreted miRNAs in the tripartite neuromuscular junction
ExRNA, 2019 microRNAs are small, non-coding, single-stranded RNAs that can suppress mRNA translation at the posttranscriptional level by binding to imperfect complementary sequences on mRNA targets and then cause their degradation or hinder protein translation ...
Liangsheng Lu +6 more
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Initial function of microRNAs as a defence mechanism against invading organisms
ExRNA, 2019 Background Although microRNA (miRNA) regulation is widely considered as a mechanism to regulate gene expression in metazoans, plants and viruses, there are recent reports that show the interaction between viruses and their mammal hosts via miRNAs ...
Xiaoshuang Liu +5 more
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In vivo self-assembled siRNA as a modality for combination therapy of ulcerative colitis
Nature Communications, 2022 Management of ulcerative colitis can require a combination of treatments targeting different pathways. Here the authors design a therapy for ulcerative colitis based on a multitargeted genetic circuit to simultaneously target TNF-α, B7-1 and integrin α4,
Xinyan Zhou +10 more
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Tumor-specific delivery of KRAS siRNA with iRGD-exosomes efficiently inhibits tumor growth
ExRNA, 2019 Lung cancer is the major cause of cancer-related deaths globally. Mutant KRAS is a feature of 15–50% of lung cancer cases and represents one of the most prevalent oncogenic drivers in this disease.
Yu Zhou +5 more
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Redox Biology, 2023 Acute kidney injury (AKI) presents a daunting challenge with limited therapeutic options. To explore the contribution of N6-methyladenosine (m6A) in AKI development, we have investigated m6A-modified mRNAs within renal tubular cells subjected to injuries
Wenwen Yang +8 more
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Co-targeting of EGFR by co-expressed miRNA-193a-3p/−5p in lung cancer
ExRNA, 2019 MicroRNAs (miRNAs) function as important oncogenes or tumor suppressors in each stage of cancer development. While previous studies focused on the individual miRNA and its specific target gene, the cooperative functions of miRNA-3p and miRNA-5p (miRNA-3p/
Kegan Zhu +8 more
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Serum microRNA Profiles Serve as Novel Biomarkers for Autoimmune Diseases
Frontiers in Immunology, 2018 Autoimmune diseases involve a complex dysregulation of immunity. Autoimmune diseases include many members [e.g., rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE)], and most of them are classified according to what organs and tissues are ...
Fangfang Jin +6 more
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Scientific Reports, 2017 The Warburg effect is a metabolic hallmark of cancer. Tumor cells rapidly adjust their energy source to glycolysis in order to efficiently proliferate in a hypoxic environment, but the mechanism underlying this switch remains incompletely understood ...
Fangfang Jin +8 more
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