Results 1 to 10 of about 471,948 (340)

A population-based statistical approach identifies parameters characteristic of human microRNA-mRNA interactions [PDF]

, 2004
BACKGROUND: MicroRNAs are ~17–24 nt. noncoding RNAs found in all eukaryotes that degrade messenger RNAs via RNA interference (if they bind in a perfect or near-perfect complementarity to the target mRNA), or arrest translation (if the binding is ...
Smalheiser, Neil R, Torvik, Vetle I
core   +5 more sources

Intrinsic noise of microRNA-regulated genes and the ceRNA hypothesis [PDF]

, 2013
MicroRNAs are small noncoding RNAs that regulate genes post-transciptionally by binding and degrading target eukaryotic mRNAs. We use a quantitative model to study gene regulation by inhibitory microRNAs and compare it to gene regulation by prokaryotic ...
Lang, Alex, Mehta, Pankaj, Noorbakhsh, Javad   +2 more
core   +11 more sources

Clusters of microRNAs emerge by new hairpins in existing transcripts [PDF]

, 2013
Genetic linkage may result in the expression of multiple products from a polycistronic transcript, under the control of a single promoter. In animals, protein-coding polycistronic transcripts are rare.
Alberts, Altschul, Altuvia, Antonio Marco, Aravin, Auyeung, Axtell, Bartel, Bartel, Barton, Baskerville, Blumenthal, Blumenthal, Boutla, Campo-Paysaa, Charlesworth, Cutter, Felsenstein, Griffiths-Jones, Griffiths-Jones, Grimson, Han, Hertel, Hill, Katoh, Kim, Kloosterman, Kozomara, Krol, Lagos-Quintana, Larkin, Lau, Lawrence, Leaman, Lee, Lee, Li, Lynch, Lynch, Maher, Marco, Marco, Marco, Marco, Marco, Maria Ninova, Matthew Ronshaugen, Maynard Smith, Nozawa, Nozawa, Qian, Roux, Ruby, Ryazansky, Saini, Saini, Saitou, Salgado, Sam Griffiths-Jones, Satou, Savard, Sempere, Tamura, Tanzer, Wheeler, Wheeler, Zeng   +66 more
core   +2 more sources

Downregulation of plasma MiR-142-3p and MiR-26a-5p in patients with colorectal carcinoma [PDF]

, 2015
Background: Colorectal cancer is one of the most commonly diagnosed cancers and cancer- related death worldwide. Identification of new specific biomarkers could be helpful to detection of this malignancy.
Asadi, J., Ghanbari, R., Knuutila, S., Malekzadeh, R., Mohamadkhani, A., Mosakhani, N., Mowla, S.J., Nouraee, N., Poustchi, H., Yazdani, Y.   +9 more
core   +1 more source

MicroRNA-222 regulates muscle alternative splicing through Rbm24 during differentiation of skeletal muscle cells [PDF]

, 2016
A number of microRNAs have been shown to regulate skeletal muscle development and differentiation. MicroRNA-222 is downregulated during myogenic differentiation and its overexpression leads to alteration of muscle differentiation process and specialized ...
Cappella, Marisa, Cardinali, B., Cittaro, D., Falcone, G., Garcia Manteiga, J. M., Lazarevic, D., Martelli, F, Provenzano, C.   +7 more
core   +2 more sources

Identifying mRNA targets of microRNA dysregulated in cancer: with application to clear cell Renal Cell Carcinoma [PDF]

, 2010
BACKGROUND. MicroRNA regulate mRNA levels in a tissue specific way, either by inducing degradation of the transcript or by inhibiting translation or transcription.
Alexe, Gabriela, Arreola, Alexandra, Bhanot, Gyan V., Brannon, Angela R., Ganesan, Shridar, Juan, David, Levine, Arnold J., Liou, Louis S., Liu, Huiqing, Oza, Jay H., Rathmell, W. K., Reddy, Anupama R., Seiler, Michael W., Yao, Ming   +13 more
core   +4 more sources

Detecting new microRNAs in human osteoarthritic chondrocytes identifies miR-3085 as a human, chondrocyte-selective, microRNA [PDF]

, 2015
Objective: To use deep sequencing to identify novel microRNAs in human osteoarthritic cartilage which have a functional role in chondrocyte phenotype or function.
Aigner, Andresen Eguiluz, Barter, Benz, Bernardo, Casagrande, Chong, Culley, D.A. Young, Diaz-Prado, Dudek, G. Wheeler, Gao, Git, Goldring, Goldring, Gomez, Grgurevic, Guo, H. Pais, Himly, I.M. Clark, Ijiri, Iliopoulos, Jin, Jones, Kato, Kozomara, L.T.T. Le, Le, Liu, Loeser, Lories, M.J. Barter, Martinez-Sanchez, Miyaki, Moxon, N. Crowe, Nakamura, Nakamura, Peffers, Prufer, S.T. Donell, Scanzello, Scott, Scott, Singh, Sorefan, Steck, Sun, Swingler, T. Dalmay, T.E. Swingler, Tardif, Team, Troeberg, Winter, Xiao, Yang, Zhai   +59 more
core   +1 more source

MicroRNA applications for prostate, ovarian and breast cancer in the era of precision medicine. [PDF]

, 2017
The high degree of conservation in microRNA from Caenorhabditiselegans to humans has enabled relatively rapid implementation of findings in model systems to the clinic.
Agarwal, Priyanka, Bhowmick, Neil A, Smith, Bethany   +2 more
core   +1 more source

Target RNAs strike back on MicroRNAs [PDF]

, 2018
MicroRNAs are extensively studied regulatory non-coding small RNAs that silence animal genes throughout most biological processes, typically doing so by binding to partially complementary sequences within target RNAs.
de la Mata, Manuel, Fededa, Juan Pablo, Fuchs Wightman, Federico, Giono, Luciana Eugenia   +3 more
core   +1 more source

Viral MicroRNA Effects on Pathogenesis of Polyomavirus SV40 Infections in Syrian Golden Hamsters [PDF]

, 2014
Shaojie Zhang, Vojtech Sroller, Preeti Zanwar, Steven J. Halvorson, Nadim J. Ajami, Corey W. Hecksel, Jody L. Swain, Connie Wong, Janet S. Butel, Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States
Ajami, Nadim J., Butel, Janet S., Chen, Chun Jung, Halvorson, Steven J., Hecksel, Corey W., Sroller, Vojtech, Sullivan, Christopher S., Swain, Jody L., Wong, Connie, Zanwar, Preeti, Zhang, Shaojie   +10 more
core   +3 more sources