Results 131 to 140 of about 21,599 (235)

Evidence of emerging transcriptome mediators of Alzheimer's disease in canine cognitive dysfunction

Brain Pathology, EarlyView.
Canine cognitive dysfunction (CCD) may be a promising model of Alzheimer's disease (AD). To assess AD‐related molecular signatures in CCD, we generated transcriptome data on dog cortex and plasma extracellular vesicles (EVs). CCD‐related transcriptome changes were similar to those in aging/AD humans and were detectable in EVs from the same animals ...
Shelby C. Osburn, Darby S. Easterday, Cali M. McEntee, Amanda S. Latham, Daniel S. Lark, Stephanie McGrath, Julie A. Moreno, Thomas J. LaRocca   +7 more
wiley   +1 more source

Clinical Significance of miR-210 and its Prospective Signaling Pathways in Non-Small Cell Lung Cancer: Evidence from Gene Expression Omnibus and the Cancer Genome Atlas Data Mining with 2763 Samples and Validation via Real-Time Quantitative PCR

Cellular Physiology and Biochemistry, 2018
Background/Aims: Since the function of microRNA (miR)-210 in non-small cell lung cancer (NSCLC) remains unclear, we aimed to explore the clinical significance of miR-210 in NSCLC.
Rong-quan He, Wei-luan Cen, Jie-mei Cen, Wei-ning Cen, Jia-yi Li, Mei-wei Li, Ting-qing Gan, Xiao-hua Hu, Gang Chen   +8 more
doaj   +1 more source

Targeting Vascular Remodeling to Treat Pulmonary Arterial Hypertension [PDF]

, 2017
Pulmonary arterial hypertension (PAH) describes a group of conditions with a common hemodynamic phenotype of increased pulmonary artery pressure, driven by progressive remodeling of small pulmonary arteries, leading to right heart failure and death ...
Lawrie, A., Thompson, A.A.R.
core   +1 more source

Prognostic significance of serum microRNA-210 levels in nonsmall-cell lung cancer

Journal of International Medical Research, 2013
Objective To investigate the levels of microRNA-210 (miR-210) in the serum of patients with nonsmall-cell lung cancer (NSCLC) and to determine whether there was a correlation with the prognosis of NSCLC patients following cisplatin-based chemotherapy. Methods Quantitative real-time reverse transcription–polymerase chain reaction was used to measure the
Zhi-Hong, Li, Hong, Zhang, Zhi-Guang, Yang, Guo-Qiang, Wen, You-Bing, Cui, Guo-Guang, Shao   +5 more
openaire   +2 more sources

Application Strategies of Bone Marrow Mesenchymal Stromal Cells in Bone‐Related Diseases

Cell Proliferation, EarlyView.
Engineered BMSCs and vesicles enhance therapy effects for bone diseases via multi‐strategic approaches. ABSTRACT Bone‐related diseases (e.g., osteoporosis, osteoarthritis and fractures) exhibit a rising global incidence, imposing significant burdens on both quality of life and healthcare systems.
Xuemei Long, Dan Tan, Qianke Tao, Qiaonan Ye, Luwen Ye, Qing Li, Jingang Xiao   +6 more
wiley   +1 more source

Implantation outcome is Associated with Mucin-16, MiR- 1226 and MiR-210 Expression during IVF of Iraqi Females

Iraqi Journal of Pharmaceutical Sciences
One of the main obstacles to early pregnancy and assisted reproduction is embryo implantation failure. Endometrial receptivity and the interactions between the embryo and the mother determine implantation.
Israa M.Majeed, Asmaa M. Salih Almohaidi
doaj   +1 more source

MicroRNA-210 Protects PC-12 Cells Against Hypoxia-Induced Injury by Targeting BNIP3

Frontiers in Cellular Neuroscience, 2017
MicroRNA (miR)-210 is the most consistently and predominantly up-regulated miR in response to hypoxia in multiple cancer cells. The roles of miR-210 in rat adrenal gland pheochromocytoma (PC-12) cells remain unknown.
Yonggang Luan, Xiaoli Zhang, Yongli Zhang, Yubin Dong   +3 more
doaj   +1 more source

Mechanisms of tumor cell resistance to the current targeted-therapy agents [PDF]

, 2016
Resistance to chemotherapy agents is a major challenge infront of cancer patient treatment and researchers. It is known that several factors, such as multidrug resistance proteins and ATP-binding cassette families, are cell membrane transporters that
Hojjat Farsangi, Mohammad, Jadidi Niaragh, Farhad, Khamisipour, Gholamreza, Sotoodeh Jahromi, Abdolreza, zandi, Keivan   +4 more
core   +2 more sources

Cellular Signalling Networks in High Altitude Pulmonary Hypertension: From Canonical Pathways to Emerging Targets

Cell Proliferation, EarlyView.
This review elucidates the intricate cellular signalling networks involved in high‐altitude pulmonary hypertension (HAPH), integrating canonical pathways like HIF, MAPK and BMP with emerging targets such as Wnt/β‐catenin, Notch, Hippo‐YAP and IL‐6. It highlights potential therapeutic strategies targeting these pathways to mitigate vascular remodelling ...
Sheng Ding, Ju Chen, Zhaoyang Li, Yang Yu, Weijie Wang, Yan Liao, Jin Yang, Dianxiang Lu, Yujiang Fan   +8 more
wiley   +1 more source

Effects of microRNA‑210 on the diagnosis and treatment of prostate cancer

Molecular Medicine Reports, 2018
The present study aimed to investigate the effects of microRNA-210 (miR-210) in the diagnosis and treatment of prostate cancer. Venous blood was collected from 30 prostate cancer patients, that were treated in the Medical Group of Ping Mei Shenma General Hospital (Pingdingshan, China) from June 2013 to May 2015, and 20 healthy men.
Yuejun, Qu, Wenqiang, Huang
openaire   +3 more sources