Results 11 to 20 of about 661,223 (352)
Predicting effective microRNA target sites in mammalian mRNAs
eLife, 2015 MicroRNA targets are often recognized through pairing between the miRNA seed region and complementary sites within target mRNAs, but not all of these canonical sites are equally effective, and both computational and in vivo UV-crosslinking approaches ...
Vikram Agarwal +3 more
semanticscholar +1 more source
MicroRNA-Based Diagnosis and Therapy
International Journal of Molecular Sciences, 2022 MicroRNAs (miRNAs) are a group of endogenous non-coding RNAs that regulate gene expression. Alteration in miRNA expression results in changes in the profile of genes involving a range of biological processes, contributing to numerous human disorders ...
P. T. Ho, I. Clark, L. Le
semanticscholar +1 more source
Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation
Frontiers in Endocrinology, 2018 MicroRNAs (miRNAs) are a class of non-coding RNAs that play important roles in regulating gene expression. The majority of miRNAs are transcribed from DNA sequences into primary miRNAs and processed into precursor miRNAs, and finally mature miRNAs.
Jacob A O'Brien +3 more
semanticscholar +1 more source
miRBase: from microRNA sequences to function
Nucleic Acids Res., 2018 miRBase catalogs, names and distributes microRNA gene sequences. The latest release of miRBase (v22) contains microRNA sequences from 271 organisms: 38 589 hairpin precursors and 48 860 mature microRNAs.
Ana Kozomara +2 more
semanticscholar +1 more source
Co-targeting of EGFR by co-expressed miRNA-193a-3p/−5p in lung cancer
ExRNA, 2019 MicroRNAs (miRNAs) function as important oncogenes or tumor suppressors in each stage of cancer development. While previous studies focused on the individual miRNA and its specific target gene, the cooperative functions of miRNA-3p and miRNA-5p (miRNA-3p/
Kegan Zhu +8 more
doaj +1 more source
Viral MicroRNA Effects on Pathogenesis of Polyomavirus SV40 Infections in Syrian Golden Hamsters [PDF]
, 2014 Shaojie Zhang, Vojtech Sroller, Preeti Zanwar, Steven J. Halvorson, Nadim J. Ajami, Corey W. Hecksel, Jody L. Swain, Connie Wong, Janet S. Butel, Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States
Ajami, Nadim J. +10 more
core +3 more sources
miRDB: an online database for prediction of functional microRNA targets
Nucleic Acids Res., 2019 MicroRNAs (miRNAs) are small noncoding RNAs that act as master regulators in many biological processes. miRNAs function mainly by downregulating the expression of their gene targets.
Yuhao Chen, Xiaowei Wang
semanticscholar +1 more source
MicroRNAs in the stressed heart: Sorting the signal from the noise [PDF]
, 2014 The short noncoding RNAs, known as microRNAs, are of undisputed importance in cellular signaling during differentiation and development, and during adaptive and maladaptive responses of adult tissues, including those that comprise the heart.
Matkovich, Scot J
core +3 more sources
Serum microRNA Profiles Serve as Novel Biomarkers for Autoimmune Diseases
Frontiers in Immunology, 2018 Autoimmune diseases involve a complex dysregulation of immunity. Autoimmune diseases include many members [e.g., rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE)], and most of them are classified according to what organs and tissues are ...
Fangfang Jin +6 more
doaj +1 more source
Redox Biology, 2023 Acute kidney injury (AKI) presents a daunting challenge with limited therapeutic options. To explore the contribution of N6-methyladenosine (m6A) in AKI development, we have investigated m6A-modified mRNAs within renal tubular cells subjected to injuries
Wenwen Yang +8 more
doaj +1 more source