Results 11 to 20 of about 282,025 (323)
Journal of Allergy and Clinical Immunology, 2018 MicroRNAs (miRNAs) are small endogenous RNAs that regulate gene-expression posttranscriptionally. MiRNA research in allergy is expanding because miRNAs are crucial regulators of gene expression and promising candidates for biomarker development.
Thomas X. Lu, Marc E. Rothenberg
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MicroRNA: MicroRNAs Reach out into Dendrites [PDF]
Current Biology, 2006 A recent study has shown that miR-134, a brain-specific microRNA, is present in dendrites where it represses the local synthesis of the protein kinase LimK1; this is a novel form of translational regulation in dendrites and may have important physiological implications.
Tai, H., Schuman, E.
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MicroRNA or Not MicroRNA? [PDF]
, 2011 The avalanche of next generation sequencing data has led to a rapid increase of annotated microRNAs in the last few years. Many of them are specific to individual species or rather narrow clades. A closer inspection of the current version of miRBase shows that dozens of entries conflict with other ncRNAs, in particular snoRNAs.With few exceptions ...
Steve Hoffmann +5 more
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MicroRNAs in Neurotoxicity [PDF]
Journal of Toxicology, 2012 MicroRNAs are gaining importance as regulators of gene expression with the capability to fine-tune and modulate cellular events. The complex network with their selective targets (mRNAs/genes) pave way for regulation of many physiological processes.
Kaur, P, Armugam, A, Jeyaseelan, K
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MicroRNAs in Development [PDF]
TSW Development & Embryology, 2006 Over 10 years ago, the lab of Victor Ambros cloned an unusual gene,lin-4, which encodes two small RNA transcripts[1]. In the past few years, hundreds more of these tiny transcripts, termed microRNAs (miRNAs), have been uncovered in over a dozen species.
Danielle M. Maatouk, Brian D. Harfe
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Modulation of microRNA Activity by Semi-microRNAs [PDF]
Frontiers in Genetics, 2012 The ribonuclease Dicer plays a central role in the microRNA pathway by catalyzing the formation of 19-24-nucleotide (nt) long microRNAs. Subsequently incorporated into Argonaute 2 (Ago2) effector complexes, microRNAs are known to regulate messenger RNA (mRNA) translation.
Preethi H. Gunaratne +6 more
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Journal of Thrombosis and Haemostasis, 2015 Epidemiologic studies have revealed that modification of the levels of individual components of the hemostatic system may have effects on the development of thrombosis or hemorrhage. To maintain the necessary equilibrium, the hemostatic system is finely regulated.
Teruel-Montoya, R. +2 more
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Sex-biased expression of microRNAs in Drosophila melanogaster [PDF]
Marco A (2014) Open Biology 4, 140024, 2013 Most animals have separate sexes. The differential expression of gene products, in particular that of gene regulators, is underlying sexual dimorphism. Analyses of sex-biased expression have focused mostly in protein coding genes. Several lines of evidence indicate that microRNAs, a class of major gene regulators, are likely to have a significant role ...
arxiv +1 more source
miR-181b functions as an oncomiR in colorectal cancer by targeting PDCD4
Protein & Cell, 2016 Programmed cell death 4 (PDCD4) is a RNA-binding protein that acts as a tumor suppressor in many cancer types, including colorectal cancer (CRC). During CRC carcinogenesis, PDCD4 protein levels remarkably decrease, but the underlying molecular mechanism ...
Yanqing Liu +16 more
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Journal of Cardiothoracic Surgery, 2023 Background Aortic dissection (AD) is a rare disease with high mortality for which no effective diagnostic biomarkers are available. Human cytomegalovirus (HCMV) infection is an important cause of the occurrence and progression of many diseases, but the ...
Yongqing Cheng +8 more
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