Results 11 to 20 of about 498,599 (357)

MicroRNA therapeutics [PDF]

Gene Therapy, 2011
MicroRNAs (miRNAs) provide new therapeutic targets for many diseases, while their myriad roles in development and cellular processes make them fascinating to study. We still do not fully understand the molecular mechanisms by which miRNAs regulate gene expression nor do we know the complete repertoire of mRNAs each miRNA regulates.
Broderick, Jennifer A, Zamore, Phillip D.   +1 more
openaire   +3 more sources

Clusters of microRNAs emerge by new hairpins in existing transcripts [PDF]

, 2013
Genetic linkage may result in the expression of multiple products from a polycistronic transcript, under the control of a single promoter. In animals, protein-coding polycistronic transcripts are rare.
Alberts, Altschul, Altuvia, Antonio Marco, Aravin, Auyeung, Axtell, Bartel, Bartel, Barton, Baskerville, Blumenthal, Blumenthal, Boutla, Campo-Paysaa, Charlesworth, Cutter, Felsenstein, Griffiths-Jones, Griffiths-Jones, Grimson, Han, Hertel, Hill, Katoh, Kim, Kloosterman, Kozomara, Krol, Lagos-Quintana, Larkin, Lau, Lawrence, Leaman, Lee, Lee, Li, Lynch, Lynch, Maher, Marco, Marco, Marco, Marco, Marco, Maria Ninova, Matthew Ronshaugen, Maynard Smith, Nozawa, Nozawa, Qian, Roux, Ruby, Ryazansky, Saini, Saini, Saitou, Salgado, Sam Griffiths-Jones, Satou, Savard, Sempere, Tamura, Tanzer, Wheeler, Wheeler, Zeng   +66 more
core   +2 more sources

Secreted miRNAs in the tripartite neuromuscular junction

ExRNA, 2019
microRNAs are small, non-coding, single-stranded RNAs that can suppress mRNA translation at the posttranscriptional level by binding to imperfect complementary sequences on mRNA targets and then cause their degradation or hinder protein translation ...
Liangsheng Lu, Yuan Liu, Yuyan Liu, Fan Zhang, Han Wang, Qipeng Zhang, Feng Pan   +6 more
doaj   +1 more source

Downregulation of plasma MiR-142-3p and MiR-26a-5p in patients with colorectal carcinoma [PDF]

, 2015
Background: Colorectal cancer is one of the most commonly diagnosed cancers and cancer- related death worldwide. Identification of new specific biomarkers could be helpful to detection of this malignancy.
Asadi, J., Ghanbari, R., Knuutila, S., Malekzadeh, R., Mohamadkhani, A., Mosakhani, N., Mowla, S.J., Nouraee, N., Poustchi, H., Yazdani, Y.   +9 more
core   +1 more source

Initial function of microRNAs as a defence mechanism against invading organisms

ExRNA, 2019
Background Although microRNA (miRNA) regulation is widely considered as a mechanism to regulate gene expression in metazoans, plants and viruses, there are recent reports that show the interaction between viruses and their mammal hosts via miRNAs ...
Xiaoshuang Liu, Xinyuan Zang, Helian Feng, Quan Zhao, Chenyu Zhang, Jin Wang   +5 more
doaj   +1 more source

In vivo self-assembled siRNA as a modality for combination therapy of ulcerative colitis

Nature Communications, 2022
Management of ulcerative colitis can require a combination of treatments targeting different pathways. Here the authors design a therapy for ulcerative colitis based on a multitargeted genetic circuit to simultaneously target TNF-α, B7-1 and integrin α4,
Xinyan Zhou, Mengchao Yu, Luzhen Ma, Jinyu Fu, Jingwei Guo, Jieqiong Lei, Zheng Fu, Yong Fu, Qipeng Zhang, Chen-Yu Zhang, Xi Chen   +10 more
doaj   +1 more source

MicroRNA-222 regulates muscle alternative splicing through Rbm24 during differentiation of skeletal muscle cells [PDF]

, 2016
A number of microRNAs have been shown to regulate skeletal muscle development and differentiation. MicroRNA-222 is downregulated during myogenic differentiation and its overexpression leads to alteration of muscle differentiation process and specialized ...
Cappella, Marisa, Cardinali, B., Cittaro, D., Falcone, G., Garcia Manteiga, J. M., Lazarevic, D., Martelli, F, Provenzano, C.   +7 more
core   +2 more sources

Cytomegalovirus microRNAs [PDF]

Current Opinion in Virology, 2014
The discovery that animals, plants and DNA viruses encode microRNAs (miRNAs) has transformed our understanding of the regulation of gene expression. miRNAs are ubiquitous small non-coding RNAs that regulate gene expression post-transcriptionally, generally by binding to sites within the 3' untranslated regions (UTR) of messenger RNA (mRNA) transcripts.
Lauren Hook, Meaghan Hancock, Igor Landais, Robert Grabski, William Britt, Jay A Nelson   +5 more
openaire   +2 more sources

Neutrophil microRNAs

Biological Reviews, 2023
ABSTRACTNeutrophils are considered ‘first‐line defence’ cells as they can be rapidly recruited to the site of the immune response. As key components of non‐specific immune mechanisms, neutrophils use phagocytosis, degranulation, and formation of neutrophil extracellular traps (NETs) to fight pathogens.
Marzena Garley, Karolina Nowak, Ewa Jabłońska   +2 more
openaire   +3 more sources

Tumor-specific delivery of KRAS siRNA with iRGD-exosomes efficiently inhibits tumor growth

ExRNA, 2019
Lung cancer is the major cause of cancer-related deaths globally. Mutant KRAS is a feature of 15–50% of lung cancer cases and represents one of the most prevalent oncogenic drivers in this disease.
Yu Zhou, Yuan Yuan, Minghui Liu, Xiuting Hu, Yiming Quan, Xi Chen   +5 more
doaj   +1 more source