Results 21 to 30 of about 282,025 (323)
Scientific Reports, 2017 The Warburg effect is a metabolic hallmark of cancer. Tumor cells rapidly adjust their energy source to glycolysis in order to efficiently proliferate in a hypoxic environment, but the mechanism underlying this switch remains incompletely understood ...
Fangfang Jin +8 more
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The Jun/miR-22/HuR regulatory axis contributes to tumourigenesis in colorectal cancer
Molecular Cancer, 2018 Background Colorectal cancer (CRC) is a severe health problem worldwide. Clarifying the mechanisms for the deregulation of oncogenes and tumour suppressors in CRC is vital for its diagnosis, treatment, prognosis and prevention.
Yanqing Liu +18 more
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Construction of a mouse model that can be used for tissue-specific EV screening and tracing in vivo
Frontiers in Cell and Developmental Biology, 2022 Extracellular vesicles (EVs) play an important role in the communication between tissues and cells. However, it is difficult to screen and trace EVs secreted by specific tissues in vivo, which affects the functional study of EVs in certain tissues under ...
Weili Li +24 more
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Intrinsic noise of microRNA-regulated genes and the ceRNA hypothesis [PDF]
PLoS ONE 8(8): e72676 (2013), 2012 MicroRNAs are small noncoding RNAs that regulate genes post-transciptionally by binding and degrading target eukaryotic mRNAs. We use a quantitative model to study gene regulation by inhibitory microRNAs and compare it to gene regulation by prokaryotic small non-coding RNAs (sRNAs).
arxiv +1 more source
Circulating microRNA, secreted microRNA and exogenous plant microRNA [PDF]
Journal of Translational Medicine, 2012 Dysregulated expression of microRNAs (miRNAs) in various tissues has been associated with a variety of diseases, including cancers. Here we demonstrate that miRNAs are present in the serum and plasma of humans and other animals such as mice, rats, bovine fetuses, calves and horses.
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MicroRNAs and Metastasis [PDF]
Cancers, 2019 Metastasis, the development of secondary malignant growths at a distance from the primary site of a cancer, is associated with almost 90% of all cancer deaths, and half of all cancer patients present with some form of metastasis at the time of diagnosis. Consequently, there is a clear clinical need for a better understanding of metastasis.
Charles H. Lawrie +2 more
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ING5 suppresses breast cancer progression and is regulated by miR-24
Molecular Cancer, 2017 Background The inhibitor of growth (ING) gene family of tumor suppressors is involved in multiple cellular functions such as cell cycle regulation, apoptosis, and chromatin remodeling.
Shufang Cui +10 more
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The Kaohsiung Journal of Medical Sciences, 2012 AbstractMicroRNAs are endogenously expressed small noncoding RNAs that regulate gene expression at the post‐transcriptional level. MicroRNAs have emerged as key regulators of several physiological and pathophysiological processes in the cardiovascular system.
Ku Chung Chen, Suh-Hang Hank Juo
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Scientific Reports, 2023 Neuropeptides are ubiquitous intercellular signaling molecules in the CNS and play diverse roles in modulating physiological functions by acting on specific G-protein coupled receptors (GPCRs). Among them, the elevenin signaling system is now believed to
Ping Fu +14 more
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Neurobiology of Disease, 2012 With an estimated life-time prevalence of 15 to 17% and an incapacitating illness in 50% of cases, depressive spectrum disorders represent a heavy public health burden. Despite considerable efforts to underpin the molecular and cellular changes associated with depressive states, a global understanding of the pathophysiology of major depressive ...
Anne Baudry +5 more
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