Results 31 to 40 of about 471,948 (340)
Neurobiology of Disease, 2012 With an estimated life-time prevalence of 15 to 17% and an incapacitating illness in 50% of cases, depressive spectrum disorders represent a heavy public health burden. Despite considerable efforts to underpin the molecular and cellular changes associated with depressive states, a global understanding of the pathophysiology of major depressive ...
Anne Baudry +5 more
openaire +4 more sources
The Jun/miR-22/HuR regulatory axis contributes to tumourigenesis in colorectal cancer
Molecular Cancer, 2018 Background Colorectal cancer (CRC) is a severe health problem worldwide. Clarifying the mechanisms for the deregulation of oncogenes and tumour suppressors in CRC is vital for its diagnosis, treatment, prognosis and prevention.
Yanqing Liu +18 more
doaj +1 more source
Journal of Cardiothoracic Surgery, 2023 Background Aortic dissection (AD) is a rare disease with high mortality for which no effective diagnostic biomarkers are available. Human cytomegalovirus (HCMV) infection is an important cause of the occurrence and progression of many diseases, but the ...
Yongqing Cheng +8 more
doaj +1 more source
Autoimmunity, 2014 Systemic lupus erythematosus is a prototypic autoimmune disease characterized by the production of an array of pathogenic autoantibodies, including high-affinity anti-dsDNA IgG antibodies, which play an important role in disease development and progression. Lupus preferentially affects women during their reproductive years. The pathogenesis of lupus is
Zan, Hong, Tat, Connie, Casali, Paolo
openaire +5 more sources
Circulating microRNA, secreted microRNA and exogenous plant microRNA [PDF]
Journal of Translational Medicine, 2012 Dysregulated expression of microRNAs (miRNAs) in various tissues has been associated with a variety of diseases, including cancers. Here we demonstrate that miRNAs are present in the serum and plasma of humans and other animals such as mice, rats, bovine fetuses, calves and horses.
openaire +2 more sources
ING5 suppresses breast cancer progression and is regulated by miR-24
Molecular Cancer, 2017 Background The inhibitor of growth (ING) gene family of tumor suppressors is involved in multiple cellular functions such as cell cycle regulation, apoptosis, and chromatin remodeling.
Shufang Cui +10 more
doaj +1 more source
Construction of a mouse model that can be used for tissue-specific EV screening and tracing in vivo
Frontiers in Cell and Developmental Biology, 2022 Extracellular vesicles (EVs) play an important role in the communication between tissues and cells. However, it is difficult to screen and trace EVs secreted by specific tissues in vivo, which affects the functional study of EVs in certain tissues under ...
Weili Li +24 more
doaj +1 more source
A novel and universal method for microRNA RT-qPCR data normalization [PDF]
, 2009 Gene expression analysis of microRNA molecules is becoming increasingly important. In this study we assess the use of the mean expression value of all expressed microRNAs in a given sample as a normalization factor for microRNA real-time quantitative PCR
De Weer, An +6 more
core +2 more sources
The Kaohsiung Journal of Medical Sciences, 2012 AbstractMicroRNAs are endogenously expressed small noncoding RNAs that regulate gene expression at the postâtranscriptional level. MicroRNAs have emerged as key regulators of several physiological and pathophysiological processes in the cardiovascular system.
Ku Chung Chen, Suh-Hang Hank Juo
openaire +4 more sources
Regulation of Cardiac MicroRNAs by Cardiac MicroRNAs [PDF]
Circulation Research, 2013 Rationale: MicroRNAs modestly suppress their direct mRNA targets, and these direct effects are amplified by modulation of gene transcription pathways. Consequently, indirect mRNA modulatory effects of microRNAs to increase or decrease mRNAs greatly outnumber direct target suppressions.
Scot J. Matkovich +2 more
openaire +2 more sources