miRBase: microRNA sequences, targets and gene nomenclature
Nucleic Acids Res., 2005 The miRBase database aims to provide integrated interfaces to comprehensive microRNA sequence data, annotation and predicted gene targets. miRBase takes over functionality from the microRNA Registry and fulfils three main roles: the miRBase Registry acts
S. Griffiths-Jones +4 more
semanticscholar +1 more source
Assessment of Circulating MicroRNAs for the Diagnosis and Disease Activity Evaluation in Patients with Ulcerative Colitis by Using the Nanostring Technology [PDF]
, 2015 Background: Clinical decision and patient care management in inflammatory bowel diseases is largely based on the assessment of clinical symptoms, while the biomarkers currently in use poorly reflect the actual disease activity.
Alexandra Touroutoglou +31 more
core +1 more source
miR-181b functions as an oncomiR in colorectal cancer by targeting PDCD4
Protein & Cell, 2016 Programmed cell death 4 (PDCD4) is a RNA-binding protein that acts as a tumor suppressor in many cancer types, including colorectal cancer (CRC). During CRC carcinogenesis, PDCD4 protein levels remarkably decrease, but the underlying molecular mechanism ...
Yanqing Liu +16 more
doaj +1 more source
Emerging role of extracellular microRNAs and lncRNAs
ExRNA, 2019 The discovery of extracellular non-coding RNAs, including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), has dramatically altered our understanding of the role RNA plays in organisms.
Geyu Zhou, Xi Chen
doaj +1 more source
ALOX5 deficiency contributes to bladder cancer progression by mediating ferroptosis escape
Cell Death and Disease, 2023 Ferroptosis is an iron-dependent form of regulated cell death driven by the lethal lipid peroxides. Previous studies have demonstrated that inducing ferroptosis holds great potential in cancer therapy, especially for patients with traditional therapy ...
Tianyao Liu +21 more
doaj +1 more source
miRBase: integrating microRNA annotation and deep-sequencing data
Nucleic Acids Res., 2010 miRBase is the primary online repository for all microRNA sequences and annotation. The current release (miRBase 16) contains over 15 000 microRNA gene loci in over 140 species, and over 17 000 distinct mature microRNA sequences.
Ana Kozomara, S. Griffiths-Jones
semanticscholar +1 more source
ExRNA, 2019 Pancreatic cancer (PaC) is one of the most aggressive malignancies. The dismal survival rate of PaC patients is mainly due to the late diagnosis and their resistance to conventional chemotherapies.
Xiaohong Jiang +5 more
doaj +1 more source
PseudoFuN: Deriving functional potentials of pseudogenes from integrative relationships with genes and microRNAs across 32 cancers [PDF]
, 2019 BACKGROUND: Long thought "relics" of evolution, not until recently have pseudogenes been of medical interest regarding regulation in cancer. Often, these regulatory roles are a direct by-product of their close sequence homology to protein-coding genes.
Campbell, Moray J. +7 more
core +1 more source
The Jun/miR-22/HuR regulatory axis contributes to tumourigenesis in colorectal cancer
Molecular Cancer, 2018 Background Colorectal cancer (CRC) is a severe health problem worldwide. Clarifying the mechanisms for the deregulation of oncogenes and tumour suppressors in CRC is vital for its diagnosis, treatment, prognosis and prevention.
Yanqing Liu +18 more
doaj +1 more source
Salmonella produce microRNA-like RNA fragment Sal-1 in the infected cells to facilitate intracellular survival. [PDF]
, 2017 Salmonella have developed a sophisticated machinery to evade immune clearance and promote survival in the infected cells. Previous studies were mostly focused on either bacteria itself or host cells, the interaction mechanism of host-pathogen awaits ...
Chen, Xi +11 more
core +2 more sources