Results 191 to 200 of about 31,660 (233)

Unveiling Gut Homeostasis Disruption in Sepsis: Towards an Integrated Mechanistic and Translational Roadmap

open access: yesCell Proliferation, Volume 59, Issue 8, August 2026.
Elucidating the contribution of gut‐organ axes will provide new insights for developing combined therapeutic strategies against sepsis‐associated multiple organ dysfunction. ABSTRACT Sepsis, a life‐threatening clinical syndrome precipitated by a maladaptive host response to infection, is associated with substantial morbidity and high mortality rates ...
Yichen Bao   +7 more
wiley   +1 more source

Exercise‐related microRNAs in Caenorhabditis elegans regulate calcium homeostasis and mitochondrial dynamics: Conserved pathways, divergent microRNAs

open access: yesThe FEBS Journal, Volume 293, Issue 16, Page 5041-5066, August 2026.
Exercise‐related microRNAs cel‐miR‐249‐3p and cel‐miR‐77‐5p in C. elegans regulate lifespan, fitness, mitochondrial morphology and membrane potential. Although lacking direct mammalian orthologs, H2O2‐induced microRNAs mmu‐miR‐181a‐5p and mmu‐miR‐378a‐3p regulate myogenesis, autophagy, mitochondrial content and respiration in murine myoblasts ...
Qin Xia   +7 more
wiley   +1 more source

LKB1 Dysregulation in Duchenne Muscular Dystrophy Models: Disease Specificity and Epigenetic Control by HDAC Inhibitors

open access: yesAnnals of the New York Academy of Sciences, Volume 1562, Issue 1, August 2026.
Our study demonstrated that the LKB1–STRADα–MO25 complex was significantly downregulated in Duchenne muscular dystrophy (DMD) models, concurring with the disruption of mechano‐metabolic signaling. Treatment with the HDAC inhibitor, vorinostat, successfully restored LKB1 expression by suppressing specific repressor miRNAs.
Brigida Boccanegra   +17 more
wiley   +1 more source

Unfolding Plant Defence: Endoplasmic Reticulum Stress Signalling at the Plant‐Pathogen Interface

open access: yesPlant Biotechnology Journal, Volume 24, Issue 8, Page 4799-4822, August 2026.
ABSTRACT The endoplasmic reticulum (ER) stress response, a conserved proteostasis network, has emerged as a central hub that reprograms plant immunity during pathogen attack. This review synthesises how plants harness ER‐stress signalling to mount multilayered defences and how pathogens have evolved counterstrategies to subvert these pathways.
Zhe Meng   +8 more
wiley   +1 more source

Circular RNAs in Lotus japonicus Responses to Nutrient Supply and Mesorhizobium Symbiosis

open access: yesPlant, Cell &Environment, Volume 49, Issue 8, Page 4823-4839, August 2026.
ABSTRACT Symbiotic interactions between legumes and rhizobia enable nitrogen fixation under low nutrient conditions. The establishment and function of symbiotic interactions require coordinated changes in gene expression in both the host and the microbe. Circular RNAs (circRNAs) are endogenous gene‐specific molecules that can regulate transcription and
Delecia Utley   +3 more
wiley   +1 more source

Efficiency and precision of microRNA biogenesis modes in plants. [PDF]

open access: yesNucleic Acids Res, 2018
Moro B   +7 more
europepmc   +1 more source

Insights from animal models: Dissecting the independent roles of oxygen and nutrients in the fetal origins of cardiovascular disease

open access: yesThe Journal of Physiology, Volume 604, Issue 16, Page 6704-6730, 15 August 2026.
Abstract figure legend This review utilized animal models of complicated human pregnancies that result in reduced fetal nutrient or oxygen delivery, or combined nutrient and oxygen delivery, to elucidate their independent and/or synergistic contributions to the development of high‐risk cardiac phenotypes.
Melanie R. Bertossa   +8 more
wiley   +1 more source

MicroRNA Biogenesis is Enhanced by Liposome-Encapsulated Pin1 Inhibitor in Hepatocellular Carcinoma. [PDF]

open access: yesTheranostics, 2019
Sun D   +8 more
europepmc   +1 more source

TSC2 regulates microRNA biogenesis via mTORC1 and GSK3β. [PDF]

open access: yesHum Mol Genet, 2018
Ogórek B   +8 more
europepmc   +1 more source

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