Results 181 to 190 of about 31,514 (218)
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Regulation of microRNA biogenesis
Nature Reviews Molecular Cell Biology, 2014MicroRNAs (miRNAs) are small non-coding RNAs that function as guide molecules in RNA silencing. Targeting most protein-coding transcripts, miRNAs are involved in nearly all developmental and pathological processes in animals. The biogenesis of miRNAs is under tight temporal and spatial control, and their dysregulation is associated with many human ...
Minju, Ha, V Narry, Kim
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MicroRNA Biogenesis in Hypoxia
MicroRNA, 2017MicroRNAs (miRNAs) are 17-22 nucleotide, non-coding, single stranded RNA molecules that play a key role in post-transcriptional gene regulation. Hypoxia is a reduction in the normal level of tissue oxygen (O2) tension, and is a feature of chronic vascular disease, pulmonary disease and many cancers.
Kanchana Veronika, Bandara +2 more
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MicroRNA Biogenesis and Cancer
2010MicroRNAs are short non-coding RNA molecules that are involved in diverse physiological and developmental processes by controlling the gene expression of target mRNAs. They play important roles in almost all kinds of cancer where they modulate key processes during tumorigenesis such as metastasis, apoptosis, proliferation, or angiogenesis. Depending on
Julia, Winter, Sven, Diederichs
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Structural Aspects of MicroRNA Biogenesis
IUBMB Life, 2004AbstractOne of the biggest surprises at the beginning of the 'post‐genome era' was the discovery of numerous genes encoding microRNAs. They were found in genomes of such diverse organisms as Caenorhabditis elegans, Drosophila melanogaster, Arabidopsis thaliana, and Homo sapiens which implies their important role in multicellular life evolution.
Jacek, Krol, Wlodzimierz J, Krzyzosiak
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MicroRNAs in platelet biogenesis and function
Thrombosis and Haemostasis, 2012SummaryPlatelets are important to maintain primary haemostasis and play a key role in pathology of thrombotic and occlusive vascular disorders such as acute coronary syndrome or stroke. Despite of lacking a nucleus and genomic DNA, platelets possess diverse types of RNAs, ranging from protein coding messenger RNAs to small non-coding RNAs inherited ...
Seema, Dangwal, Thomas, Thum
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MicroRNA biogenesis and function. An overview.
Advances in experimental medicine and biology, 2011During the last decade of the 20th century a totally novel way of gene regulation was revealed. Findings that at first glance appeared freak features of plants or C. elegans turned out to be mechanistically related and deeply conserved throughout evolution.
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MicroRNA Biogenesis: Dicing Assay
2014RNA-induced silencing complex is the cytoplasmic effector machine of the microRNA (miRNA) pathway and contains a single-stranded miRNA guiding it to its target mRNAs. The biogenesis of mature miRNAs is a regulatory process achieved by complex machinery composed of few protein components, among which the ribonuclease III Dicer plays a central role ...
Carlos A, Melo, Sonia A, Melo
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Regulation of microRNA biogenesis and function
Thrombosis and Haemostasis, 2012SummaryMicroRNAs (miRNAs) are considered as key regulators of literally all cellular pathways. Therefore, miRNA biosynthesis and their individual cellular functions must be tightly regulated as well. MiRNAs are transcribed as primary transcripts, which are processed to mature miRNAs in two consecutive maturation steps.
T, Treiber, N, Treiber, G, Meister
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microRNAs in action: biogenesis, function and regulation
Nature Reviews Genetics, 2023Ever since microRNAs (miRNAs) were first recognized as an extensive gene family >20 years ago, a broad community of researchers was drawn to investigate the universe of small regulatory RNAs. Although core features of miRNA biogenesis and function were revealed early on, recent years continue to uncover fundamental information on the structural and ...
Renfu Shang +3 more
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The biogenesis and regulation of animal microRNAs
Nature Reviews Molecular Cell BiologyMicroRNAs (miRNAs) are small, yet profoundly influential, non-coding RNAs that base-pair with mRNAs to induce RNA silencing. Although the basic principles of miRNA biogenesis and function have been established, recent breakthroughs have yielded important new insights into the molecular mechanisms of miRNA biogenesis.
Haedong Kim +2 more
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