Results 101 to 110 of about 282,884 (301)
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
The Specific microRNA Profile and Functional Networks for Children with Allergic Asthma
Journal of Asthma and Allergy, 2022 Xiyan Zhang,1 Xude Zhang,1 Shaojie Feng,1 Xijuan Wang,1 Beibei Guo,1 Jingjing Liu,1 Donghua Xu,2,3 Fengxia Liu1 1Department of Allergy, Weifang People’s Hospital, Weifang, People’s Republic of China; 2Clinical Medicine College, Weifang Medical University,
Zhang X +7 more
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Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To evaluate the expression of nine blood RNA biomarkers in a clinical trial based on genes previously identified in an experimental monkey model of stroke for diagnosis feasibility and prognostication. Methods IBIS‐CT1 was a prospective longitudinal study enrolling patients with ischemic stroke (IS) or intracerebral hemorrhage (ICH ...
Salomé Retailleau +11 more
wiley +1 more source
Diagnostic Value of Combining miRNAs, CEA Measurement and the FOBT in Colorectal Cancer Screening
Cancer Management and Research, 2020 Xiaodan Li,1 Rong Chen,2 Zhifa Li,2 Bing Luo,1 Wenyan Geng,1 Xiaobing Wu2 1Clinical Laboratory, The Third Affiliated Hospital of the Guangzhou Medical University, Guangzhou 510150, People’s Republic of China; 2Gastrointestinal Surgery, The Third ...
Li X, Chen R, Li Z, Luo B, Geng W, Wu X
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MicroRNAs in skeletogenesis [PDF]
Frontiers in Bioscience, 2009 MicroRNAs (miRNAs) are a class of highly conserved small noncoding RNAs that negatively regulate gene expression by imperfectly base pairing to the 3'-untranslated region of their target mRNAs, leading to mRNA degradation or translational inhibition.
openaire +2 more sources
Cells, 2022 Firstly, I apologize for the delayed publication of this Special Issue in the form of a book title [...]
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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Multiple sclerosis (MS) is a neurodegenerative demyelinating disease of the central nervous system. This study aimed to identify micro‐RNA (miRNA)–mRNA regulatory networks underlying region‐specific molecular mechanisms in white matter and gray matter lesions in progressive MS.
Adya Sapra +5 more
wiley +1 more source
RNAi and retroviruses: are they in RISC?
Biomolecular Concepts, 2013 RNA interference (RNAi) is a potent cellular system against viruses in various organisms. Although common traits are observed in plants, insects, and nematodes, the situation observed in mammals appears more complex.
Vasselon Thierry +3 more
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