Results 51 to 60 of about 580,775 (413)

CHO microRNA engineering is growing up : recent successes and future challenges [PDF]

, 2013
microRNAs with their ability to regulate complex pathways that control cellular behavior and phenotype have been proposed as potential targets for cell engineering in the context of optimization of biopharmaceutical production cell lines, specifically of
Barron, Niall, Betenbaugh, Mike, Borth, Nicole, Chung, Cheng-Yu, Druz, Aliaksandr, Grillari, Johannes, Hackl, Matthias, Heffner, Kelley M., Jadhav, Vaibhav, Kreil, David, Shiloach, Joseph, Shridhar, Smriti   +11 more
core   +1 more source

Isoflavone daidzein ameliorates renal dysfunction and fibrosis in a postmenopausal rat model: Intermediation of angiotensin AT1 and Mas receptors and microRNAs 33a and 27a [PDF]

Iranian Journal of Basic Medical Sciences, 2022
Objective(s): Chronic kidney disease (CKD), accompanied by renal dysfunction, fibrosis, and apoptosis, is highly prevalent in postmenopausal women. We tested the hypothesis that isoflavone daidzein may ameliorate renal dysfunction and fibrosis through ...
Majid Askaripour, Hamid Najafipour, Shadan Saberi, Saleh Yazdani, Saeideh Jafarinejad-Farsangi, Soodeh Rajabi, Elham Jafari, Paul Proost, Sofie Struyf, Fariba Poosti   +9 more
doaj   +1 more source

Specific requirements of MRFs for the expression of muscle specific microRNAs, miR-1, miR-206 and miR-133 [PDF]

, 2008
The expression of three microRNAs, miR-1, miR-206 and miR-133 is restricted to skeletal myoblasts and cardiac tissue during embryo development and muscle cell differentiation, which suggests a regulation by muscle regulatory factors (MRFs).
Anderson, Andrea Münsterberg, Bennett, Braun, Buckingham, Callis, Carvajal, Carvajal, Chen, Chen, Dalmay, Darnell, de Alvaro, Delfini, Dylan Sweetman, Eisenberg, Gayraud-Morel, Gensch, Groom, Haldar, Hamburger, Harfe, Harris, He, Hornstein, Kassar-Duchossoy, Katarzyna Goljanek, Kim, Kontaridis, Kuwahara, Lai, Liu, Lluis, Maroto, McCarthy, McCarthy, McCarthy, O'Rourke, Olwin, Pena, Perry, Portier, Rao, Rawls, Rosenberg, Rudnicki, Rudnicki, Sebolt-Leopold, Smith, Svetlana Oustanina, Sweetman, Tajbakhsh, Tamas Dalmay, Tapscott, Thomas Braun, Tina Rathjen, Ustanina, van Rooij, Wienholds, Xiao, Yue, Zhang   +61 more
core   +1 more source

Regulation of Cardiac MicroRNAs by Cardiac MicroRNAs [PDF]

Circulation Research, 2013
Rationale: MicroRNAs modestly suppress their direct mRNA targets, and these direct effects are amplified by modulation of gene transcription pathways. Consequently, indirect mRNA modulatory effects of microRNAs to increase or decrease mRNAs greatly outnumber direct target suppressions.
Scot J. Matkovich, Yuanxin Hu, Gerald W. Dorn   +2 more
openaire   +2 more sources

MicroRNAs in lung cancer [PDF]

, 2017
Lung cancer (LC) is a serious public health problem responsible for the majority of cancer deaths and comorbidities in developed countries. Tobacco smoking is considered the main risk factor for LC; however, only a few smokers will be affected by this ...
An, Baltimore, Belinsky, Brennan, Chen, De Flora, De Flora, Dong, Duan, Gomez, Hao, Harris, Hasegawa, Haugen, Hu, Inoue, Jemal, Jia, Lam, Li, Liu, Nakanishi, Neilson, O'Driscoll, Pan, Peiper, Ren, Schmeck, Schrump, Sensinger, Shah, Slack, Speiser, Stampfli, Wang, Wang, Yoshida, You, Zhang, Zhang, Zienolddiny   +40 more
core   +1 more source

miRNAs as Interconnectors between Obesity and Cancer

Non-Coding RNA
Obesity and cancer are a concern of global interest. It is proven that obesity may trigger the development or progression of some types of cancer; however, the connection by non-coding RNAs has not been totally explored. In the present review, we discuss
Grecia Denisse González-Sánchez, Angelica Judith Granados-López, Yamilé López-Hernández, Mayra Judith García Robles, Jesús Adrián López   +4 more
doaj   +1 more source

The epigenetics of diabetes, obesity, overweight and cardiovascular disease

AIMS Genetics, 2019
The objectives of this review were once to understand the roles of the epigenetics mechanism in different types of diabetes, obesity, overweight, and cardiovascular disease. Epigenetics represents a phenomenon of change heritable phenotypic expression of
Harem Othman Smail
doaj   +1 more source

Mammalian microRNAs predominantly act to decrease target mRNA levels

Nature, 2010
MicroRNAs (miRNAs) are endogenous ∼22-nucleotide RNAs that mediate important gene-regulatory events by pairing to the mRNAs of protein-coding genes to direct their repression.
Huili Guo, Nicholas T. Ingolia, J. Weissman, D. Bartel   +3 more
semanticscholar   +1 more source

Vascular microRNAs

Current Drug Targets, 2010
MicroRNAs are endogenously expressed small non-coding RNAs that regulate gene expression on the posttranscriptional level. During the last years microRNAs have emerged as key regulators of several physiological and pathophysiological processes in the vascular wall.
Angelika Bonauer, Reinier A. Boon, Stefanie Dimmeler   +2 more
openaire   +3 more sources

Alzheimer’s disease: presence and role of microRNAs

Biomolecular Concepts, 2016
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that accounts for the most cases of dementia. AD affects more than 25 million people globally and is predicted to affect nearly one in 85 people worldwide by 2050.
Basavaraju Manasa, de Lencastre Alexandre   +1 more
doaj   +1 more source