Results 121 to 130 of about 109,422 (246)

Preimplantation Genetic Testing of Spinocerebellar Ataxia Type 2-Robust Tools for Direct and Indirect Detection of the ATXN2 CAG Repeat Expansion. [PDF]

Int J Mol Sci
Asherah N, Lian M, Tan AS, Taguchi R, Chua P, Liu S, Lee CG, Chong SS.   +7 more
europepmc   +1 more source

Species‐Specific Genetic Patterns in Sympatric Freshwater Turtles Challenge a Generalized Multi‐Species Conservation Approach

Animal Conservation, EarlyView.
We compared genetic diversity and spatial genetic structure in the snapping turtle (Chelydra serpentina; left panel), Blanding's turtle (Emydoidea blandingii; bottom right), and spotted turtle (Clemmys guttata; top right) sampled in areas of co‐occurrence across ~49,160 km2.
Christina M. Davy, Erica Newton, Niamh Wall, Robert W. Murphy   +3 more
wiley   +1 more source

Genetic and Clinical Characteristics of Patients With Tumor Mutation Burden-High Unresectable Pancreatic Cancer and the Efficacy of Pembrolizumab Treatment. [PDF]

Cancer Rep (Hoboken)
Kai Y, Ikezawa K, Kozumi K, Urabe M, Takada R, Kinomoto T, Masumoto T, Kawabata M, Kishimoto H, Hosokawa K, Mukai K, Nakabori T, Yamaguchi Y, Sugimoto N, Ohkawa K.   +14 more
europepmc   +1 more source

Genotyping Contemporary Captive and Historical Wild Western Lowland Gorillas Indicates Captive Breeding Is Maintaining Genetic Diversity in a Critically Endangered Primate

Animal Conservation, EarlyView.
Captive populations of threatened species risk losing genetic diversity over time. We evaluated the genetic status of contemporary captive western lowland gorillas (Gorilla gorilla gorilla) at Howletts and Port Lympne and compared this with specimens from a historical wild population.
Jaimie Morris, Tony King, John Hills, Simon C. Harvey, Jane Hopper, Rodrigo Vega   +5 more
wiley   +1 more source

Microsatellite status and its correlation with clinicopathological features in gastric carcinoma: insights from a retrospective study in Northern Pretoria. [PDF]

Pathol Oncol Res
Kgokong N, McCabe M, Mhlongo LN, Nkwagatse T, Khaba MC.   +4 more
europepmc   +1 more source

Personalized Cancer Vaccines in the Clinical Trial Pipeline

Asia-Pacific Journal of Clinical Oncology, EarlyView.
This study analyzes the current landscape of personalized cancer vaccine clinical trials, highlighting trends in vaccine platforms, trial phases, and geographic distribution. Peptide and dendritic cell vaccines dominate early‐stage research, with promising immune responses observed in melanoma, glioblastoma, and urothelial cancer trials.
Liudmila Iamukova, Elena Alferova
wiley   +1 more source

Low microsatellite instability revisited: a review. [PDF]

Virchows Arch
Grosser B, Kohlruss M, Keller G.
europepmc   +1 more source

Impact of Metformin and Diabetes on Tumor Response to Total Neoadjuvant Therapy in Advanced Rectal Cancer: A Multicenter Retrospective Cohort Study

Asia-Pacific Journal of Clinical Oncology, EarlyView.
In advanced rectal cancer patients receiving total neoadjuvant therapy (TNT), overall tumor response did not differ by diabetes status or metformin use. However, among diabetic patients, metformin use was associated with higher overall complete response rates. These findings suggest a potential benefit of metformin in enhancing TNT response in diabetic
Sergei Bedrikovetski, Mahima Raju, Tracy Fitzsimmons, Ishraq Murshed, Timothy J. Price, Michael Penniment, Sudarsha Selva‐Nayagam, Tarik Sammour   +7 more
wiley   +1 more source

Clinical and immunological implications of lymphocyte-activation gene 3 expression in metastatic colorectal cancer. [PDF]

Cancer Immunol Immunother
Huang YH, Wu SY, Lee CT, Chung BS, Lin PC, Chan RH, Chen PC, Lin BW, Shen MR, Chen SH, Yeh YM.   +10 more
europepmc   +1 more source

Broader Familial Cancer Risk in Relatives of Testicular Cancer Patients: Insights From Two Mediterranean Populations

Andrology, EarlyView.
ABSTRACT Background Familial clustering of testicular germ cell tumour (TGCT) is well‐established, whereas the risk of non‐testicular cancer among relatives remains inconsistent across studies. Objective To evaluate the overall and site‐specific cancer risk among first‐degree relatives and grandparents of TGCT patients compared to cancer‐free controls.
Csilla Krausz, Chiara Abrardo, Viktoria Rosta, Daniel Moreno‐Mendoza, Luca Bressan, Matteo Vannucci, Rebecca Passerotti, Arianna Meacci, Ginevra Farnetani, Viola Bonini, Giovanni Corona, Maria Grazia Fino, Eduard Ruiz‐Castañé, Antoni Riera‐Escamilla   +13 more
wiley   +1 more source