Results 151 to 160 of about 109,422 (246)

Evaluating the Impact of Putative Metformin Targets on Cancer Outcomes: A Drug‐Target Mendelian Randomization Study

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Observational studies show metformin use associated with lower cancer risk, although experimental evidence is inconsistent. To provide genetic validation for repositioning of metformin in cancer prevention, we assessed genetically proxied effects of putative metformin targets on cancer outcomes using a drug‐target Mendelian randomization (
Xingyu Shen, Shan Luo, Jie Zheng, Celine Sze Ling Chui, Ian Chi Kei Wong, Eric Yuk Fai Wan, Catherine Mary Schooling, Shiu Lun Au Yeung   +7 more
wiley   +1 more source

Improving the performance of polymerase chain reaction for microsatellite instability testing in endometrial cancer. [PDF]

Sci Rep
Mendiola M, Heredia-Soto V, Baillo A, Ruz-Caracuel I, Mena R, Berjón A, Escudero FJ, Pedregosa J, Hernandez A, Feliu J, Hardisson D, Redondo A.   +11 more
europepmc   +1 more source

Microsatellite Stable [PDF]

, 2020
openaire   +1 more source

Do aphid endosymbiotic bacteria influence parasitoid searching behaviour through changes in aphid honeydew production?

Ecological Entomology, EarlyView.
Hamiltonella defensa infection increases honeydew production in certain aphid genotypes, potentially modifying aphid feeding behaviour. Parasitoid wasps, Aphidius ervi, are more attracted to honeydew from H. defensa‐infected aphids; though larger honeydew amounts may slightly deter searching.
Desiré Macheda, Alexandre Foito, Katharine F. Preedy, Colin J. Alexander, Ankush Prashar, Alison J. Karley   +5 more
wiley   +1 more source

Mismatch repair deficiency and microsatellite instability in adrenocortical carcinoma. [PDF]

ESMO Open
Altieri B, Kircher S, Herterich S, Jahn A, Teleanu MV, Lippert J, Landwehr LS, Kimpel O, Reuter M, Remde H, Stenzinger A, Glimm H, Bargou RC, Fröhling S, Ronchi CL, Appenzeller S, Fassnacht M, Kroiss M.   +17 more
europepmc   +1 more source

Compound‐Specific Stable Isotope Analysis Reveals Population‐Specific Differences in Chinook Salmon Trophic Level and Basal Resource Use in the Northeast Pacific

Fisheries Oceanography, EarlyView.
ABSTRACT Chinook salmon exhibit far‐flung and disparate population‐specific marine migrations that have made it difficult to assess their trophic ecology. In this study, we collected returning and resident subadult Fraser River Chinook salmon in 2018 and 2019 from population groups with different known run‐timings (spring, summer, and fall) and marine ...
Jacob E. Lerner, Brian P. V. Hunt
wiley   +1 more source

Case Report: A case of Lynch syndrome-related glioblastoma with coexisting <i>MSH2</i> splicing defect and <i>MSH6</i> frameshift mutation. [PDF]

Front Oncol
Huang L, Tang X, Cao D, Li Y, Zhu X.
europepmc   +1 more source

Human papilloma virus infection and mismatch repair protein expression in sebaceous neoplasms of the genital area

Histopathology, EarlyView.
This study establishes the role of high‐risk HPV infection in cutaneous sebaceous carcinoma of the genital area. An intraepithelial component in a subset of cases poses a challenge to distinguish the entity from squamous cell carcinoma in situ. Rarely, sebaceous neoplasia of the genital area is associated with Muir–Torre syndrome. Aims This study aimed
Katharina Wiedemeyer, Zainab Al‐Shamma, Martin Köbel, Ingrid Ferreira, Paul W. Harms, Thomas Brenn   +5 more
wiley   +1 more source

Advancing Genetic Stock Identification of Leatherback Turtles From Foraging Grounds in the Southwest Atlantic: Insights From Nuclear DNA (nDNA) Analysis. [PDF]

Ecol Evol
Prosdocimi L, Roden SE, Velez-Rubio GM, Fallabrino A, López-Mendilaharsu M, LaCasella EL, Dutton PH.   +6 more
europepmc   +1 more source

Molecular pathology of phyllodes tumours of the breast—much more than MED12

Histopathology, EarlyView.
Phyllodes tumours can develop from fibroadenomas bearing MED12 variants by the development of pTERT alterations (“MED12 pathway”) or de novo (“MED12 independent pathway”). Grade progression is associated with increasing genetic complexity including cancer driver gene aberrations. Molecular alterations can be useful in assigning grade and distinguishing
Jia‐Min B Pang, Kylie L Gorringe, Puay Hoon Tan, Stephen B Fox   +3 more
wiley   +1 more source