Results 141 to 150 of about 124,795 (370)

Colorectal cancer carcinogenesis: a review of mechanisms

Cancer Biology & Medicine, 2016
Colorectal cancer (CRC) is the second most common cancer in women and the third most common in men globally. CRC arises from one or a combination of chromosomal instability, CpG island methylator phenotype, and microsatellite instability.
Kanwal Tariq, Kulsoom Ghias
doaj   +1 more source

Electrochemical Biosensors for Cancer Biomarker Detection: Basic Concept, Design Strategy and Cutting‐Edge Development

Electrochemical Science Advances, EarlyView.
ABSTRACT Cancer is a result of uncontrolled cell growth with the potential to damage or spread to another part of the body. It is the deadliest disease in the world; therefore, rapid and sensitive detection is essential to fight it. In the past few decades, many diagnosis tools have been developed to detect cancer and monitor therapy progress.
Md Mobarok Karim, Tahera Lasker
wiley   +1 more source

Squamous Cell Carcinoma of the Lung With Microsatellite Instability in a Patient With Lynch Syndrome: A Case Report

JTO Clinical and Research Reports
Lynch syndrome is the most common autosomal dominant inherited cancer predisposing syndrome, due to mutations in DNA mismatch repair genes. The key feature of cancers in Lynch syndrome is microsatellite instability and a high risk of developing mainly ...
Emna Haddad, MD, Benjamin Bottet, MD, Pierre-Alain Thiebaut, MD, PhD, Samira Morin, MD, Hélène Dreyfus, MD, Élise Vannier, MD, Colette Vincent, MD, Florent Marguet, MD, PhD, Aude Lamy, PhD, Hagay Sobol, MD, PhD, Jean-Marc Baste, MD, PhD, Florian Guisier, MD, PhD, Jean-Christophe Sabourin, MD, PhD, Nicolas Piton, MD, PhD   +13 more
doaj  

Strong HLA-DR expression in microsatellite stable carcinomas of the large bowel is associated with good prognosis [PDF]

Progression of colorectal cancer may follow either of two main genetic routes: the chromosome- or microsatellite-instability pathways. Association between the patients' prognosis and microsatellite instability has been questioned.
A Di Giorgio, A Hemminki, A Loukola, AC Lazaris, B Curran, C B Diep, CM Wright, CR Boland, E-S Chang, G Bardi, G I Meling, GI Meling, H Elsaleh, H Kim, I Sæterdal, J Gutierrez, J Jass, J Klein, J Ruschoff, JM Michael-Robinson, JR Jass, JR Jass, JR Lukish, JT Johannsdottir, KC Halling, KM Feeley, KM Ropponen, KW Kinzler, L Messerini, L Thorstensen, L Thorstensen, LA Aaltonen, M Guidoboni, M Kunihiro, M Morita, MJ Massa, P Brandtzaeg, PH Rooney, PM De Angelis, R A Lothe, R Dolcetti, R Gryfe, R Ward, RA Lothe, S N Andersen, S Norheim Andersen, S Salahshor, S Senba, SN Thibodeau, SN Thibodeau, T Løvig, T O Rognum, T Watanabe, TC Smyrk, TO Rognum, TO Rognum, TO Rognum, VJ Bubb, XP Zhou, Y Ionov, Y Naito   +60 more
core   +2 more sources

Association between Genetic Instability and Helicobacter pylori Infection in Gastric Epithelial Dysplasia

Gastroenterology Research and Practice, 2012
Background. In gastric carcinogenesis, changes of DNA methylation appear to be an early molecular event, and the genome-wide methylation state is closely correlated with the level of long interspersed nucleotide element-1 (LINE-1) methylation.
Jin Su Kim, Woo Chul Chung, Kang-Moon Lee, Chang Nyol Paik, Kyeong Soo Lee, Hye Ji Kim, Young Wook Kim, Ji Han Jung, Seung June Noh, Yun Kyung Lee   +9 more
doaj   +1 more source

Epigenomics‐guided precision oncology: Chromatin variants in prostate tumor evolution

International Journal of Cancer, EarlyView.
Abstract Prostate cancer is a common malignancy that in 5%–30% leads to treatment‐resistant and highly aggressive disease. Metastasis‐potential and treatment‐resistance is thought to rely on increased plasticity of the cancer cells—a mechanism whereby cancer cells alter their identity to adapt to changing environments or therapeutic pressures to create
Kira Furlano, Tina Keshavarzian, Nadine Biernath, Annika Fendler, Maria de Santis, Joachim Weischenfeldt, Mathieu Lupien   +6 more
wiley   +1 more source

Association of Hereditary Nonpolyposis Colorectal Cancer–Related Tumors Displaying Low Microsatellite Instability with MSH6 Germline Mutations [PDF]

, 1999
Ying Wu, Maran J.W. Berends, Rob G.J. Mensink, Claudia Kempinga, Rolf H. Sijmons, Ate G.J. van der Zee, Harry Hollema, Jan H. Kleibeuker, Charles H.C.M. Buys, Robert M.W. Hofstra   +9 more
openalex   +1 more source

Microsatellite Instability and Loss of Heterozygosity in Melanoma

Journal of Investigative Dermatology, 1995
Alterations in the repeat length of microsatellites have been identified recently in tumors arising in patients with hereditary nonpolyposis colon cancer and in several human sporadic tumors. We examined 40 sporadic melanomas and their corresponding nontumorous skin for microsatellite instability (MSI) and loss of heterozygosity (LOH) at chromosomes 2q,
Peris, Ketty, Keller, G, Chimenti, S, Amantea, A, Kerl, H, Höfler, H.   +5 more
openaire   +4 more sources

Temporal trends in incidence and mortality of colorectal cancer in Denmark from 2007 to 2022

International Journal of Cancer, EarlyView.
What's New? Colorectal cancer (CRC) is the third most common cancer in the Western world. Widespread use of screening programs has helped raise awareness of the disease and improve survival rates. To make sure screening, treatment, research, and education goals stay relevant, it is important to collect accurate population‐based estimates of CRC ...
Ida Ravnsbæk Johannsen, Anders Kindberg Boysen, Frank V. Mortensen, Jakob Kirkegård   +3 more
wiley   +1 more source

Chromosomal instability in untreated primary prostate cancer as an indicator of metastatic potential. [PDF]

, 2020
BackgroundMetastatic prostate cancer (PC) is highly lethal. The ability to identify primary tumors capable of dissemination is an unmet need in the quest to understand lethal biology and improve patient outcomes.
Cadaneanu, Radu M, Freeman, Michael R, Garraway, Isla P, Grasso, Catherine S, Hodge, Jennelle, Kim, Minhyung, Knudsen, Beatrice S, Kwan, Lorna, Lewis, Michael S, Li, Xinmin, Liu, Sandy T, Miller, Eric T, Quist, Michael J, Yoon, Junhee, You, Sungyong   +14 more
core