Results 141 to 150 of about 859,289 (399)
Self supervised learning improves dMMR/MSI detection from histology slides across multiple cancers [PDF]
Proceedings of the MICCAI Workshop on Computational Pathology,
156, 2021, 191-205, 2021 Microsatellite instability (MSI) is a tumor phenotype whose diagnosis largely impacts patient care in colorectal cancers (CRC), and is associated with response to immunotherapy in all solid tumors. Deep learning models detecting MSI tumors directly from H&E stained slides have shown promise in improving diagnosis of MSI patients.
arxiv
Molecular Alterations and Association with Clinical Parameters [PDF]
, 2015 Lynch syndrome is caused by germline mutations of DNA mismatch repair (MMR) genes, most frequently MLH1 and MSH2. Recently, MMR-deficient crypt foci (MMR- DCF) have been identified as a novel lesion which occurs at high frequency in the intestinal mucosa
Benner, Axel +11 more
core +1 more source
Advanced Science, EarlyView.This study introduces cuproptosis nanoplatform, a novel nanoplatform using Cu2−XS hollow nanospheres, elesclomol, and lauric acid (LA) for self‐amplified cuproptosis. NIR‐II laser activation melts LA, releasing copper ions and elesclomol to enhance copper delivery within tumor cells, reduce glutathione's inhibitory effect, and trigger immunogenic cell ...
Runzi Cheng +10 more
wiley +1 more source
The Subtype-Free Average Causal Effect for Heterogeneous Disease Etiology [PDF]
arXiv, 2022 Studies have shown that the effect an exposure may have on a disease can vary for different subtypes of the same disease. However, existing approaches to estimate and compare these effects largely overlook causality. In this paper, we study the effect smoking may have on having colorectal cancer subtypes defined by a trait known as microsatellite ...
arxiv
Journal of Clinical Oncology, 2019 PURPOSE CALGB/SWOG 80405 was a randomized phase III trial that found no statistically significant difference in overall survival (OS) in patients with first-line metastatic colorectal cancer treated with chemotherapy plus either bevacizumab or cetuximab.
F. Innocenti +15 more
semanticscholar +1 more source
Advanced Science, EarlyView.xxxx. Abstract Nutrient metabolisms are vitally interrelated to cancer progression and immunotherapy. However, the mechanisms by which nutrient metabolisms interact to remodel immune surveillance within the tumor microenvironment remain largely unexplored.
Qi‐Long Wang +16 more
wiley +1 more source
Molecular Ecology Resources, EarlyView., 2023 Abstract A high‐quality reference genome can be a valuable resource for threatened species by providing a foundation to assess their evolutionary potential to adapt to future pressures such as environmental change. We assembled the genome of a female hihi (Notiomysits cincta), a threatened passerine bird endemic to Aotearoa New Zealand.
Sarah Bailey +7 more
wiley +1 more source
Microsatellite instability in Marek’s Disease Virus infected primary chicken embryo fibroblasts
Virology Journal, 2012 Background Marek’s disease virus (MDV), an oncogenic α-herpes virus, causes a devastating disease in chickens characterized by development of lymphoblastoid tumors in multiple organs.
Zhou Zhenlei +3 more
doaj +1 more source
End-to-end Learning for Image-based Detection of Molecular Alterations in Digital Pathology [PDF]
arXiv, 2022 Current approaches for classification of whole slide images (WSI) in digital pathology predominantly utilize a two-stage learning pipeline. The first stage identifies areas of interest (e.g. tumor tissue), while the second stage processes cropped tiles from these areas in a supervised fashion. During inference, a large number of tiles are combined into
arxiv
Annals of Gastroenterological Surgery, EarlyView.Preoperative GPS2 is an independent poor prognostic factor in patients with colorectal cancer and synchronous peritoneal metastases, and surgical resection does not improve prognosis in patients with GPS2. Preoperative GPSs may be used as indicators for surgical resection of synchronous peritoneal metastases.
Kosuke Fujimoto +31 more
wiley +1 more source