Results 191 to 200 of about 55,423 (289)

Additional file 3 of The MLH1 polymorphism rs1800734 and risk of endometrial cancer with microsatellite instability

, 2020
Holly Russell, Katarzyna Kedzierska, Daniel D. Buchanan, Rachael Thomas, Emma Tham, Miriam Mints, Anne Keränen, Graham G. Giles, Melissa C. Southey, Roger L. Milne, Ian Tomlinson, David N. Church, Amanda B. Spurdle, Tracy A. O’Mara, Annabelle Lewis   +14 more
openalex   +1 more source

Proteogenomic Characterization Reveals Metabolic Vulnerabilities and Aberrant Phosphorylation in Colorectal Metastasis to Liver

Advanced Science, Volume 13, Issue 4, 19 January 2026.
This study provides a multi‐omics landscape of treatment‐naïve colorectal liver metastasis and reveals dysregulated molecules and cellular pathways. SHMT1 and NDRG1 Ser330 phosphorylation are demonstrated to display crucial roles in tumorigenesis and liver metastasis. Two proteomics subtypes (metabolism and RNA function) with distinct clinical outcomes
Wensi Zhao, Lei Zhao, Yannan Lian, Zhiwei Liu, Yaqi Li, Xuege Wang, Mingya Zhang, Ni Li, Jingli Guo, Danqing Shen, Shaobo Mo, Jiahao Li, Linhui Zhai, Jiahui Ni, Sangkyu Lee, Bin Liu, Jing Li, Fei Wang, Junjie Peng, Jun Qin, Minjia Tan   +20 more
wiley   +1 more source

EMQN best practice guidelines for analysis and reporting of microsatellite instability in solid tumours. [PDF]

Eur J Hum Genet
Gallon R, McCormick L, Saetta A, Albuquerque C, Butler S, Cranston T, Field J, McAnulty C, Silva P, Cheetham M, Sheils K, Burghel GJ.   +11 more
europepmc   +1 more source

Large proportion of low frequency microsatellite-instability and loss of heterozygosity in pheochromocytoma and endocrine tumors detected with an extended marker panel

, 2007
Susan Kupka, Birgit Haack, Marty Zdichavsky, Tanja Mlinar, Christine Kienzle, C.–Thomas Bock, Reinhard Kandolf, Stefan-Martin Kroeber, Alfred Königsrainer   +8 more
openalex   +2 more sources

PD-L1 expression in colorectal cancer is associated with microsatellite instability, BRAF mutation, medullary morphology and cytotoxic tumor-infiltrating lymphocytes [PDF]

, 2016
Matthew W. Rosenbaum, Jacob R. Bledsoe, Vicente Morales‐Oyarvide, Tiffany G. Huynh, Mari Mino–Kenudson   +4 more
openalex   +1 more source

Immunometabolic Rewiring of Dendritic Cells to Overcome Glutamine‐Driven Immune Suppression in Colorectal Cancer

Advanced Science, Volume 13, Issue 5, 27 January 2026.
T26 is an immunometabolic prodrug that modulates colorectal cancer cells. It blocks glutamine metabolism and enhances STING signaling, which promotes the release of reprogrammed extracellular vesicles. These vesicles drive dendritic cell maturation and CD8⁺ T cell activation, thereby strengthening antitumor immunity and improving the effectiveness of ...
Bingjie Zhang, Renming Fan, Yongrui Hai, Ye Chen, Xintong Lu, Wenhui Wang, Jiarui Dou, Jiaxin Yan, Chang Su, Yue Chen, Le Yang, Minggao Zhao, Lei Liang, Gaofei Wei   +13 more
wiley   +1 more source

An Ensemble Deep Learning-Based Approach for Microsatellite Instability Prediction in Gastrointestinal Cancer

youmna Ahmed radwan, Hossam Moustafa, Adel F. Mohamed Moustafa, Saleh Ahmed   +3 more
openalex   +1 more source

69P Next generation sequencing in colorectal cancer: Association of BRAF, KRAS mutations with right sided cancers, mucinous disease, lymphovascular/perineural invasion and microsatellite instability [PDF]

Gurpreet Singh Ranger, Jill J. Ranger, Keeley Barnable, Vett K. Lloyd, Mary Kate Hart   +4 more
openalex   +1 more source

T Cell Exhaustion and Dendritic Cell‐Mediated Tertiary Lymphoid Structures (TLSs) Modulation Affect Response to Neoadjuvant Chemoradiotherapy in Microsatellite Stable Rectal Cancer

Advanced Science, Volume 13, Issue 4, 19 January 2026.
Using multi‐omics analysis, this study demonstrates that immune characteristics of the tumor microenvironment, rather than mutational profiles, are more strongly correlated with treatment response. Specifically, early exhausted T cells and tertiary lymphoid structures regulation by LAMP3⁺ dendritic cells emerge as key predictors of favorable outcomes ...
Miao Wang, Jiejun Shi, Kai Xu, Leyi Yu, Xiaomao Yin, Jiexuan Wang, Lin Zhu, Xin Yang, Jingjing Qian, Wenqiang Wang, Liangchen Zhu, Xuan Dai, Zekun Zhao, Jinran Wu, Dongsheng Li, Zhiqian Hu, Qi Huang, Xinxing Li   +17 more
wiley   +1 more source

Integrative Multi‐Omics Analysis Uncovers Immunological Phenotypes Predictive of Combinatorial Immunotherapy Response in Gastric Cancer

Advanced Science, Volume 13, Issue 6, 30 January 2026.
Current understanding of gastric cancer immunity remains inadequate, leading to suboptimal immunotherapy outcomes. This study introduces a novel tumor immune microenvironment classification system (Inflamed, Desert, and Excluded), advancing traditional histopathological or molecular subtyping toward a functional immunological framework.
Jianchao Wang, Wenfang Zhang, Jiyang Zhang, Chenhui Zhao, Wei Zhang, Menghan Fang, Fangfang Chen, Zhida Wu, Xiaoya Xu, Ziqing Yu, Qiong Zhu, Yi Shi, Dadong Zhang, Xiaofeng Chen, Gang Chen   +14 more
wiley   +1 more source