Results 191 to 200 of about 859,289 (399)

MLH1 promoter hypermethylation is associated with the microsatellite instability phenotype in sporadic endometrial carcinomas [PDF]

, 1998
Manel Esteller, Ross L. Levine, Stephen B. Baylin, Lora H. Ellenson, James G. Herman   +4 more
openalex   +1 more source

Fusobacterium nucleatum in Colorectal Cancer Relates to Immune Response Differentially by Tumor Microsatellite Instability Status

Cancer immunology research, 2018
In patients with colorectal cancer, the presence of Fusobacterium nucleatum may suppress immune responses for microsatellite instability (MSI)-high tumors and encourage immune responses for non-MSI-high tumors. F.
Tsuyoshi Hamada, Xuehong Zhang, K. Mima, S. Bullman, Y. Sukawa, J. Nowak, K. Kosumi, Y. Masugi, Tyler S. Twombly, Yin Cao, M. Song, Li Liu, Annacarolina da Silva, Yan Shi, Mancang Gu, Wan-Ying Li, Hideo Koh, K. Nosho, K. Inamura, N. Keum, Kana Wu, J. Meyerhardt, A. Kostic, C. Huttenhower, W. Garrett, M. Meyerson, E. Giovannucci, A. Chan, C. Fuchs, Reiko Nishihara, M. Giannakis, S. Ogino   +31 more
semanticscholar   +1 more source

Stage‐specific characterization of “early‐onset colorectal cancer”: Localized and synchronous metastatic disease

International Journal of Cancer, EarlyView.
What's New? The incidence of early‐onset colorectal cancer (EOCRC) has been raising, and stage‐specific characteristics and prognosis need to be clarified. In this study, more than 90% of EOCRC cases presented with symptoms. Among patients with localized cancer, female gender, perineural invasion, and intense treatment were more frequent in early than ...
Erman Akkus, Beliz Bahar Karaoğlan, Mehmet Kayaalp, Utkucan Turmuş, Cihangir Akyol, Güngör Utkan   +5 more
wiley   +1 more source

Microsatellite Instability and Loss of Heterozygosity in Melanoma

Journal of Investigative Dermatology, 1995
Alterations in the repeat length of microsatellites have been identified recently in tumors arising in patients with hereditary nonpolyposis colon cancer and in several human sporadic tumors. We examined 40 sporadic melanomas and their corresponding nontumorous skin for microsatellite instability (MSI) and loss of heterozygosity (LOH) at chromosomes 2q,
Peris, Ketty, Keller, G, Chimenti, S, Amantea, A, Kerl, H, Höfler, H.   +5 more
openaire   +4 more sources

Frequent Microsatellite Instability and Mismatch Repair Gene Mutations in Young Chinese Patients With Colorectal Cancer [PDF]

, 1999
Tzu-Liang Chan, ST Yuen, Leland W.K. Chung, Judy Ho, Kedo Kwan, Annie S.Y. Chan, Jenny Ho, Suet Yi Leung, A H Wyllie   +8 more
openalex   +1 more source

Retained Mismatch Repair Protein Expression Occurs in Approximately 6% of Microsatellite Instability-High Cancers and is Associated with Missense Mutations in Mismatch Repair Genes.

Modern Pathology, 2019
Immunohistochemistry for mismatch repair protein expression is widely used as a surrogate for microsatellite instability status—an important signature for immunotherapy and germline testing.
J. Hechtman, Satshil Rana, S. Middha, Z. Stadler, Alicia J Latham, R. Benayed, R. Soslow, M. Ladanyi, R. Yaeger, A. Zehir, J. Shia   +10 more
semanticscholar   +1 more source

Predisposing conditions in patients with small intestinal adenocarcinomas in the Netherlands: A 20‐year nationwide cohort study

International Journal of Cancer, EarlyView.
What's New? Although small intestinal adenocarcinoma (SIA) shares certain similarities with colorectal cancer, its etiology and predisposing conditions presumably are distinct. Due to the rarity of SIA, however, detailed information on predisposing factors is lacking.
Jasmijn D. G. Linssen, Pascale J. M. Schafrat, Tim R. de Back, Felice N. van Erning, Monique E. van Leerdam, Evelien Dekker, Louis Vermeulen, Ignace H. J. T. de Hingh, Dirkje W. Sommeijer   +8 more
wiley   +1 more source

A simple approach for detecting HLA‐A*02 alleles in archival formalin‐fixed paraffin‐embedded tissue samples and an application example for studying cancer immunoediting

HLA, Volume 101, Issue 1, Page 24-33, January 2023., 2023
The HLA system represents a central component of the antigen presentation machinery. As every patient possesses a defined set of HLA molecules, only certain antigens can be presented on the cell surface. Thus, studying HLA type‐dependent antigen presentation can improve the understanding of variation in susceptibility to various diseases, including ...
Johannes Witt, Saskia Haupt, Aysel Ahadova, Lena Bohaumilitzky, Vera Fuchs, Alexej Ballhausen, Moritz Jakob Przybilla, Michael Jendrusch, Toni T. Seppälä, Daniel Fürst, Thomas Walle, Elena Busch, Georg Martin Haag, Robert Hüneburg, Jacob Nattermann, Magnus von Knebel Doeberitz, Vincent Heuveline, Matthias Kloor   +17 more
wiley   +1 more source

Clinical Aspects of Microsatellite Instability Testing in Colorectal Cancer

Advanced Biomedical Research, 2018
Microsatellite instability (MSI) is a molecular hallmark for some colorectal cancers (CRCs) in which short tandem repeats are prone to mutations along with DNA sequences.
Mehrdad Zeinalian, Morteza Hashemzadeh-Chaleshtori, Rasoul Salehi, Mohammad Hassan Emami   +3 more
doaj   +1 more source

Temporal trends in incidence and mortality of colorectal cancer in Denmark from 2007 to 2022

International Journal of Cancer, EarlyView.
What's New? Colorectal cancer (CRC) is the third most common cancer in the Western world. Widespread use of screening programs has helped raise awareness of the disease and improve survival rates. To make sure screening, treatment, research, and education goals stay relevant, it is important to collect accurate population‐based estimates of CRC ...
Ida Ravnsbæk Johannsen, Anders Kindberg Boysen, Frank V. Mortensen, Jakob Kirkegård   +3 more
wiley   +1 more source