Results 201 to 210 of about 124,795 (370)

The impact of Foxp3+ regulatory T‐cells on CD8+ T‐cell dysfunction in tumour microenvironments and responses to immune checkpoint inhibitors

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitors (ICIs) have been a breakthrough in cancer therapy, inducing durable remissions in responding patients. However, they are associated with variable outcomes, spanning from disease hyperprogression to complete responses with the onset of immune‐related adverse events.
Mikhaël Attias, Ciriaco A. Piccirillo
wiley   +1 more source

Microsatellite instability in early sporadic breast cancer

, 1996
Jacqui Shaw, Tom Walsh, SA Chappell, Nessa Carey, Keith Johnson, RA Walker   +5 more
openalex   +1 more source

PTEN methylation is associated with advanced stage and microsatellite instability in endometrial carcinoma [PDF]

, 2000
Helga B. Salvesen, Nicola MacDonald, Andy Ryan, Ian Jacobs, Eric D. Lynch, Lars A. Akslen, Soma Das   +6 more
openalex   +1 more source

Treatment options for immune‐related adverse events associated with immune checkpoint inhibitors

British Journal of Pharmacology, EarlyView.
Abstract The immunotherapy revolution with the use of immune checkpoint inhibitors (ICIs) started with the clinical use of the first ICI, ipilimumab, in 2011. Since then, the field of ICI therapy has rapidly expanded — with the FDA approval of 10 different ICI drugs so far and their incorporation into the therapeutic regimens of a range of malignancies.
Yu Hua Chen, Tamás Kovács, Péter Ferdinandy, Zoltán V. Varga   +3 more
wiley   +1 more source

Genomic profiles of patients with skin melanoma in the era of immune checkpoint inhibitors

Cancer Science, Volume 116, Issue 4, Page 1107-1114, April 2025.
We investigated the genomic profiles of patients with skin melanoma who had received immune checkpoint inhibitors and explored associations with clinical features and outcomes via a large‐scale nationwide database in Japan (the C‐CAT database). Patients with multiple (two or more) liver metastases or brain metastases were more likely to have NOTCH3 or ...
Yao Liang, Osamu Maeda, Kazuki Nishida, Basile Chretien, Yuichi Ando   +4 more
wiley   +1 more source

Deficient Mismatch Repair and Microsatellite Instability in Solid Tumors. [PDF]

Int J Mol Sci
Awosika JA, Gulley JL, Pastor DM.
europepmc   +1 more source

Microsatellite instability in Japanese gastric cancer

, 1995
Hideaki Nakashima, Hiroshi Inoue, Masaki Mori, Hiroaki Ueo, Masahito Ikeda, Tsuyoshi Akiyoshi   +5 more
openalex   +1 more source

Sensitivity to CPT-11 of xenografted human colorectal cancers as a function of microsatellite instability and p53 status [PDF]

, 2000
Rui Bras-Gonçalves, Christophe Rosty, Pierre Laurent‐Puig, P Soulié, Bernard Dutrillaux, M F Poupon   +5 more
openalex   +1 more source

CXCL9 and CXCL13 shape endometrial cancer immune‐activated microenvironment via tertiary lymphoid structure formation

Cancer Science, Volume 116, Issue 5, Page 1193-1202, May 2025.
Focusing on differences in immunogenicity, we analyzed the immune microenvironment specific to cancer with high immunogenicity and found that CXCL9 and CXCL13 are associated with the formation of an activated immune microenvironment around cancer with high immunogenicity through the formation of TLS.
Yoshihiro Nagase, Makoto Kodama, Eriko Aimono, Kohei Nakamura, Reika Takamatsu, Keiko Abe, Takuma Yoshimura, Tatsuyuki Chiyoda, Wataru Yamagami, Hiroshi Nishihara   +9 more
wiley   +1 more source

Microsatellite Instability in the Tumor Microenvironment: The Role of Inflammation and the Microbiome. [PDF]

Cancer Med
Vargas-Castellanos E, Rincón-Riveros A.
europepmc   +1 more source