Results 201 to 210 of about 88,754 (292)

Unraveling epigenetic heterogeneity across gastrointestinal adenocarcinomas through a standardized analytical framework

Molecular Oncology, Volume 19, Issue 4, Page 1117-1131, April 2025.
This study shows that patients with gastrointestinal adenocarcinomas can be stratified into six distinct subtypes based on genome‐scale DNA methylation profiling. This stratification, achieved using a robust analytical framework, aligns with established tumor characteristics and holds potential to support prognostication.
Rita Pinto, Hege Marie Vedeld, Guro Elisabeth Lind, Marine Jeanmougin   +3 more
wiley   +1 more source

More subtle microsatellite instability better predicts fluorouracil insensitivity in colorectal cancer patients. [PDF]

Sci Rep
Miyashita K, Shioi S, Kajitani T, Koi Y, Shimokawa M, Makiyama A, Oda S, Esaki T.   +7 more
europepmc   +1 more source

Microsatellite Instability and k‐ras, p53 Mutations in Thyroid Lymphoma [PDF]

, 2000
Tetsuya Takakuwa, Tadashi Hongyo, Mukh Syaifudin, Hiroyuki Kanno, Fumio Matsuzuka, Isamu Narabayashi, Taisei Nomura, Katsuyuki Aozasa   +7 more
openalex   +1 more source

Real‐world genomic landscape of colon and rectal cancer

FEBS Open Bio, Volume 15, Issue 4, Page 674-685, April 2025.
We confirmed enrichment of RTK alterations in patients with RAS/BRAF‐wt tumors and of PI3K pathway alterations in RAS/BRAF‐altered tumors with 51 982 real‐world tissue comprehensive genomic profiling (CGP) samples in CRC. In a subset of 140 patients with both tissue and liquid results, the sensitivity of liquid for results found by tissue was 100% when
Markus Schulze, XiaoZhe Wang, Jawad Hamad, Julia C. F. Quintanilha, Lincoln W. Pasquina, Julia F. Hopkins, Juergen Scheuenpflug, Zheng Feng   +7 more
wiley   +1 more source

Linking LEDGF/p75 Overexpression With Microsatellite Instability and KRAS Mutations: A Small-Scale Study in Colorectal Cancer. [PDF]

Cancer Control
Liedtke V, Wartmann T, Shi W, Kahlert UD.   +3 more
europepmc   +1 more source

Advances in Fecal Microbiota Transplantation for Gut Dysbiosis‐Related Diseases

Advanced Science, Volume 12, Issue 13, April 3, 2025.
This article reviews the use of fecal microbiota transplantation (FMT) to treat intestinal diseases like recurrent Clostridioides difficile infection (rCDI), inflammatory bowel disease (IBD), and irritable bowel syndrome (IBS). It discusses FMT's efficacy, influencing factors such as donor selection, recipient characteristics, and treatment protocols ...
Shuna Hou, Jiachen Yu, Yongshuang Li, Duoyi Zhao, Zhiyu Zhang   +4 more
wiley   +1 more source

Effects of Microsatellite Instability on the Clinical and Pathological Characteristics of Colon Cancer and the Diagnostic Accuracy of Preoperative Abdominal CT Scans. [PDF]

Diagnostics (Basel)
Yavuz R, Aras O, Çiyiltepe H, Dinçer Oİ, Alparslan AŞ, Çakır T.   +5 more
europepmc   +1 more source

Somatic mutations in mitochondrial DNA do not associate with nuclear microsatellite instability in gastrointestinal cancer [PDF]

, 2000
Simó Schwartz, Manuel Perucho
openalex   +1 more source

Honokiol‐Magnolol‐Baicalin Possesses Synergistic Anticancer Potential and Enhances the Efficacy of Anti‐PD‐1 Immunotherapy in Colorectal Cancer by Triggering GSDME‐Dependent Pyroptosis

Advanced Science, Volume 12, Issue 13, April 3, 2025.
In this study, Honokiol (H)‐magnolol (M)‐baicalin (B) is identified as the primary active ingredients of Huangqin Houpo decoction. The HMB combination not only possesses potent synergistic anticancer activity, but also enhances the effectiveness of anti‐PD‐1 immunotherapy by inducing GSDME‐dependent pyroptosis in CRC cells.
Quan Gao, Qinsong Sheng, Zijing Yang, ZhiYu Zhu, Lin Li, Lihui Xu, Jing Xia, Yunhao Qiao, Jie Gu, Xiaolong Zhu, Tian Xie, Xinbing Sui   +11 more
wiley   +1 more source

Liver metastases and peritoneal metastases and response to checkpoint inhibitors in metastatic colorectal cancer with microsatellite instability. [PDF]

Oncologist
Fakih M, Sandhu J, Li X, Wang C.
europepmc   +1 more source