Results 201 to 210 of about 55,423 (289)

Detection of urothelial carcinoma in Lynch syndrome using microsatellite instability analysis of urine cell-free DNA. [PDF]

EBioMedicine
Hall R, Gallon R, Hayes C, Herrero-Belmonte P, Phelps R, Job D, Wake R, Ferrier M, Turner H, O'Donnell R, Nambiar A, Rai B, Martin R, McAnulty C, Santibanez-Koref M, Heer R, Jackson MS, Burn J.   +17 more
europepmc   +1 more source

No Evidence of Microsatellite Instability and Loss of Mismatch-Repair-Protein Expression in Squamous Cell Carcinoma of the Penis [PDF]

, 2019
Robert Stoehr, Olaf Wendler, Johannes Giedl, Nadine T. Gaisa, Georg Richter, Valentina Câmpean, Maximilian Burger, Bernd Wullich, Simone Bertz, Arndt Hartmann   +9 more
openalex   +1 more source

Inducible T‐Cell Co‐Stimulator (ICOS) and ICOS Ligand: Dealing With a Two‐Faced Cancer Immunoregulatory System

Cancer Medicine, Volume 15, Issue 1, January 2026.
ICOS (inducible T‐cell co‐stimulator) and ICOS ligand (ICOSL) are part of an important, complex pathway that can lead to both immune stimulation and suppression. Both ICOS agonists and antagonists are under development as oncology therapeutics and biomarker driven approaches will be important to ascertain which patients will derive the greatest benefit
Mina Nikanjam, Shumei Kato, Daisuke Nishizaki, Hirotaka Miyashita, Sarabjot Pabla, Mary K. Nesline, Heidi Ko, Jeffrey M. Conroy, Aung Naing, Razelle Kurzrock   +9 more
wiley   +1 more source

Evaluation of microsatellite instability patterns in mismatch repair deficiency: a retrospective analysis of 285 endometrial cancers. [PDF]

Front Immunol
Wang C, Feng M, Kou Y, Kuang W, Wang W, Liang D.   +5 more
europepmc   +1 more source

Distinct Molecular and Prognostic Profiles of Left‐ and Right‐Sided Colorectal Cancer Revealed by NGS Analysis: The Role of SMAD4 and SETD2 Mutations

Cancer Medicine, Volume 15, Issue 1, January 2026.
ABSTRACT Background Colorectal cancer (CRC) isthe third most common cancer and the second leading cause of cancer‐relateddeath worldwide. Its genetic heterogeneity complicates treatment. This studyaimed to compare clinicopathological, molecular, and prognostic factors betweenleft‐sided (LCC) and right‐sided (RCC) CRC.
Wenlei Zhao, Yuxuan Qiu, Na Bai, Chunhong He, Jiani C. Yin, Qianru Xu, Kaiyu Jian, Baolei Jia, Lin Jiang, Feng Liang   +9 more
wiley   +1 more source

Targeting the Werner syndrome protein in microsatellite instability cancers: mechanisms and therapeutic potential. [PDF]

Clin Exp Med
Chen S, Wang Z, Cao Z, Xu M, Zhang Y.
europepmc   +1 more source

Additional file 2: of Cell-free DNA profiling of metastatic prostate cancer reveals microsatellite instability, structural rearrangements and clonal hematopoiesis

, 2018
Markus Mayrhofer, Bram De Laere, Tom Whitington, Peter Van Oyen, Christophe Ghysel, J Ampe, Piet Ost, Wim Demey, Lucien Hoekx, Dirk Schrijvers, Barbara Brouwers, Willem Lybaert, Els Everaert, Daan De Maeseneer, Michiel Strijbos, Alain Bols, Karen Fransis, Steffi Oeyen, Pieter‐Jan van Dam, Gert Van den Eynden, Annemie Rutten, Markus Aly, Tobias NordstrĂśm, Steven Van Laere, Mattias Rantalainen, Prabhakar Rajan, Lars Egevad, Anders UllĂŠn, Jeffrey Yachnin, Luc Dirix, Henrik GrĂśnberg, Johan Lindberg   +31 more
openalex   +1 more source

Circulating tumor DNA informs clinical practice in patients with recurrent/metastatic gastroesophageal cancers

Cancer, Volume 132, Issue 1, 1 January 2026.
Abstract Background Circulating tumor DNA (ctDNA) is a valuable biomarker for assessing treatment response and molecular residual disease. In advanced esophageal and gastric cancer (gastroesophageal cancer [EGC]), ctDNA dynamics remain poorly understood.
Rutika Mehta, Samuel Rivero‐Hinojosa, Farshid Dayyani, Jenifer Ferguson, Bushra Shariff, Vasily N. Aushev, Griffin L. Budde, J. Bryce Ortiz, Giby V. George, Shruti Sharma, Adham A. Jurdi, Minetta C. Liu, Ronald L. Drengler, Samuel J. Klempner   +13 more
wiley   +1 more source

Immunotherapy Plus Surgery Improves Survival in Microsatellite Instability-High Colon Cancer with Isolated Peritoneal Metastases. [PDF]

Cancers (Basel)
Metzger DA, Chahal Y, Watman O, Li Y, Pigazzi A, Siolas D, Jafari MD.   +6 more
europepmc   +1 more source

Phase II clinical trial of nirogacestat in patients with relapsed ovarian granulosa cell tumours

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
Evidence suggests NOTCH activation is among the survival and proliferation pathways interacting with FOXL2 c.402C > G (p.Cys134Trp) mutation in granulosa cell tumours (GCT). This Phase II clinical trial of nirogacestat in GCT achieved its enrolment target in < 1 year and primary analysis within 2 years.
Rachel N. Grisham, Elizabeth Hopp, Kathryn Pennington, Robert Holloway, Robert M. Wenham, Pawel Blecharz, Lauren Dockery, Koji Matsuo, Ritu Salani, Mariusz Bidzinski, Patricia Braly, Paul Celano, Thomas Reid, Shelly Seward, Jocelyn Lewis, Mark Johnson, Robert DuBose, Sarah Ahn, Shinta Cheng, Carmelita Alvero, Panagiotis A. Konstantinopoulos   +20 more
wiley   +1 more source