Results 221 to 230 of about 88,754 (292)

Mismatch Repair Status and Lymph Node Ratio in Survival Prediction of Stage II/III Rectal Cancer Patients: A Comprehensive Analysis of a Multi‐Center Retrospective Study

Cancer Medicine, Volume 14, Issue 7, April 2025.
ABSTRACT Background The microsatellite status (dMMR vs. pMMR) in colorectal cancer can serve as a guiding factor for patient prognosis and treatment, where dMMR status indicates a better prognosis and often obviates the need for adjuvant chemotherapy (ACT). Conversely, a higher lymph node ratio (LNR) is associated with a poorer prognosis.
Kailong Zhao, Wenwen Pang, Xinyu Liu, Kemin Ni, Weifeng Gao, Zhiquan Tan, Jun Xue, Weizheng Liang, Xueliang Wu, Xipeng Zhang, Xiaomin Su, Chunze Zhang   +11 more
wiley   +1 more source

A deep multiple instance learning framework improves microsatellite instability detection from tumor next generation sequencing. [PDF]

Nat Commun
Ziegler J, Hechtman JF, Rana S, Ptashkin RN, Jayakumaran G, Middha S, Chavan SS, Vanderbilt C, DeLair D, Casanova J, Shia J, DeGroat N, Benayed R, Ladanyi M, Berger MF, Fuchs TJ, Brannon AR, Zehir A.   +17 more
europepmc   +1 more source

Detecting PI3K and TP53 Pathway Disruptions in Early‐Onset Colorectal Cancer Among Hispanic/Latino Patients

Cancer Medicine, Volume 14, Issue 7, April 2025.
This study identifies distinct PI3K and TP53 pathway disruptions in early‐onset colorectal cancer among Hispanic/Latino patients, with findings suggesting a higher prevalence of PI3K alterations and potential differences in outcomes associated with TP53 disruptions compared to non‐Hispanic Whites.
Cecilia Monge, Brigette Waldrup, Sophia Manjarrez, Francisco G. Carranza, Enrique Velazquez‐Villarreal   +4 more
wiley   +1 more source

Microsatellite Instability Testing and Prognostic Implications in Colorectal Cancer. [PDF]

Cancers (Basel)
Ho V, Chung L, Wilkinson K, Ma Y, Rutland T, Lea V, Lim SH, Abubakar A, Ng W, Lee M, Roberts TL, Becker TM, Mackenzie S, Chua W, Lee CS.   +14 more
europepmc   +1 more source

Genomic Differences and Distinct TP53 Mutation Site‐Linked Chemosensitivity in Early‐ and Late‐Onset Gastric Cancer

Cancer Medicine, Volume 14, Issue 8, April 2025.
ABSTRACT Background Gastric cancer (GC) in younger patients often exhibits aggressive behavior and a poorer prognosis than that in older patients. Although the clinical differences may stem from oncogenic gene variations, it is unclear whether genetic differences exist between these groups.
Tomohiro Kamio, Yoshiyasu Kono, Kensuke Hirosuna, Toshiki Ozato, Hideki Yamamoto, Akira Hirasawa, Daisuke Ennishi, Shuta Tomida, Shinichi Toyooka, Motoyuki Otsuka   +9 more
wiley   +1 more source

Detecting microsatellite instability by length comparison of microsatellites in the 3' untranslated region with RNA-seq. [PDF]

Brief Bioinform
Choi JW, Lee JO, Lee S.
europepmc   +1 more source

The NLRP1 Emerges as a Promising Therapeutic Target and Prognostic Biomarker Across Multiple Cancer Types: A Comprehensive Pan‐Cancer Analysis

Cancer Medicine, Volume 14, Issue 8, April 2025.
NLRP1, a key component of the inflammasome complex, has emerged as a significant factor in cancer development. Through a systematic in silico study, we observed NLRP1 dysregulation in multiple tumor types, with significant correlations to survival outcomes, cancer‐associated fibroblast infiltration, and drug sensitivity, highlighting its potential as a
Leila Habibipour, Mahboubeh Sadeghi, Alireza Raghibi, Nima Sanadgol, Amirhossein Mohajeri Khorasani, Pegah Mousavi   +5 more
wiley   +1 more source

Potential value of novel multiparametric MRI radiomics for preoperative prediction of microsatellite instability and Ki-67 expression in endometrial cancer. [PDF]

Sci Rep
Wang Z, Hu Y, Cai J, Xie J, Li C, Wu X, Li J, Luo H, He C.   +8 more
europepmc   +1 more source

Immunohistochemical‐Based Molecular Typing of ACRG Combined With Immune‐Associated PD‐L1 Expression Can Predict the Prognosis of Gastric Cancer

Cancer Medicine, Volume 14, Issue 7, April 2025.
ABSTRACT Background Gastric cancer (GC) is a molecularly heterogeneous disease with diverse clinical outcomes. Traditional classifications lack predictive accuracy, necessitating alternative molecular subtyping approaches for effective prognosis prediction. The Asian Cancer Research Group (ACRG) molecular subtypes, combined with immune‐associated PD‐L1
Fang Li, Huiyan Deng, Zeqing Hu, Zihao Chen, Huirui Zhang, Jiankun He, Xiaoxiao Wang, Yueping Liu   +7 more
wiley   +1 more source

Microsatellite Instability, Epstein-Barr Virus, p53, and β-Catenin in Early Gastric Cancers: Clinicopathologic Association. [PDF]

In Vivo
Kim J, Choi J, Kwon HJ, Kim M.
europepmc   +1 more source