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Microsatellite instability in breast cancer
Annals of Surgical Oncology, 1997Microsatellites are short repetitive nucleotide sequences that, through mutation, can undergo either expansion or contraction. This novel mutational mechanism known as microsatellite instability may play a role in carcinogenesis. We investigated the incidence of microsatellite instability in a series of primary breast carcinoma surgical specimens.Using
E B, Rush +4 more
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Microsatellite instability associated with hepatocarcinogenesis
Journal of Hepatology, 1999The biological and clinicopathological significance of microsatellite instability in hepatocellular carcinoma still remains to be determined. The aim of this study was to assess the role of microsatellite instability in hepatocarcinogenesis.Genomic DNA extracted from 38 fresh samples of hepatocellular carcinoma was amplified by polymerase chain ...
Y, Kondo +5 more
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Microsatellite DNA Instability in COPD
Chest, 1999Cigarette smoking is the prime cause of COPD; however, only a few smokers develop the disease. In a previous study, we demonstrated that microsatellite DNA instability (MSI) is a detectable phenomenon in sputum cells of COPD patients. Therefore, we hypothesize that this genetic alteration may indicate susceptibility to COPD.In order to investigate this
N M, Siafakas +6 more
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Microsatellite Instability in Hematologic Malignancies
Leukemia & Lymphoma, 1997Malignant transformation in humans occurs via different mechanisms including the activation of oncogenes and/or loss of tumor suppressor genes. Recently, DNA mismatch repair defects manifest as genome wide microsatellite instability have been described as an additional mechanism of tumorgenesis in humans.
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Nihon rinsho. Japanese journal of clinical medicine, 2012
Tamotsu, Sugai +3 more
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Tamotsu, Sugai +3 more
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PCR Analysis of Microsatellite Instability
2003Microsatellites are simple, tandemly repeated DNA sequences which are abundantly distributed throughout the human genome, and because of their polymorphic nature have been widely utilized as genetic markers (1). They consist of a repeating unit of 1-5 base pairs, averaging 25-60 bases in length, and are commonly found in the form d(CA)n:d(GT)n (2).
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Microsatellite instability in melanoma
Melanoma Research, 1994G J, Walker +4 more
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Microsatellite Instability in Pediatric Gliomas
American Journal of Clinical Pathology, 2021openaire +2 more sources