Results 231 to 240 of about 124,795 (370)

Genome‐Wide Screening in Haploid Stem Cells Reveals Synthetic Lethality Targeting MLH1 and TP53 Deficient Tumours

Cell Proliferation, EarlyView.
To identify genetic events that can lead to tumour death once either MLH1 or TP53 is mutated, a genome‐wide genetic screening was performed, uncovering a list of putative hits. Synthetic lethal interactions were validated either genetically or chemically by using small molecules that inhibit these genes either in vitro and in vivo.
Rivki Cashman, Guy Haim‐Abadi, Elyad Lezmi, Hagit Philip, Jonathan Nissenbaum, Ruth Viner‐Breuer, Chen Kozulin, Tamar Golan‐Lev, Aseel Gadban, Shiri Spinner‐Potesky, Ofra Yanuka, Oded Kopper, Nissim Benvenisty   +12 more
wiley   +1 more source

Pathogenic germline variants in mismatch repair genes in patients with microsatellite instability-high gastric cancer. [PDF]

Chin J Cancer Res
Yun JH, Song GJ, Cho I, Yun S, Son MW, Kim SH, Lee MS, Choi YY.   +7 more
europepmc   +1 more source

Extrachromosomal Circular DNA in Cancer: Mechanisms and Clinical Applications

Cell Proliferation, EarlyView.
ABSTRACT Extrachromosomal circular DNA (eccDNA) has emerged as a critical area of cancer research due to its ubiquitous presence in tumour cells and significant role in tumorigenesis, progression and drug resistance. Recent studies demonstrate that eccDNA promotes cancer progression by influencing genomic instability, amplifying oncogenes, regulating ...
Jiajia Li, Peng Luo, Zhengrui Li, Qi Wang, Xufeng Huang, Keliang Wang, Ruo Wang, Runzhi Chen   +7 more
wiley   +1 more source

Predictive value of combined DCE-MRI perfusion parameters and clinical features nomogram for microsatellite instability in colorectal cancer. [PDF]

Discov Oncol
Peng L, Ma W, Zhang X, Zhang F, Ma F, Ai K, Ma X, Jia Y, Ou-Yang H, Pei S, Wang T, Zhu Y, Wang L.   +12 more
europepmc   +1 more source

Microsatellite instability involves in carcinogenesis of well differentiated gastric cancer

, 1998
Kazuhiro Kashiwagi, T. Tahara, Takahiro Ezaki, Mae Nakano, Takeshi Hisamatsu, Etsuro Ogata, H Ishii, Yujirou Iwao, Tomoya Kanai, Masataka Watanabe, Toshifumi Hibi∥   +10 more
openalex   +1 more source

Associations Between Cigarette Smoking, Lifestyle Factors, and Microsatellite Instability in Colon Tumors [PDF]

, 2000
M. L. Slattery
openalex   +1 more source

Deciphering the Immunomodulatory Function of GSN+ Inflammatory Cancer‐Associated Fibroblasts in Renal Cell Carcinoma Immunotherapy: Insights From Pan‐Cancer Single‐Cell Landscape and Spatial Transcriptomics Analysis

Cell Proliferation, EarlyView.
Pan‐cancer scRNA‐seq and ST‐seq analyses identify GSN+ inflammatory cancer‐associated fibroblasts (CAFs) and their spatial distribution in immune checkpoint inhibitor (ICI) therapy. The Caf.Sig model accurately predicts ICI response across cancers using CAF gene signatures and machine learning.
Shan Li, Xinwei Zhou, Haoqian Feng, Kangbo Huang, Minyu Chen, Mingjie Lin, Hansen Lin, Zebing Deng, Yuhang Chen, Wuyuan Liao, Zhengkun Zhang, Jinwei Chen, Bohong Guan, Tian Su, Zihao Feng, Guannan Shu, Anze Yu, Yihui Pan, Liangmin Fu   +18 more
wiley   +1 more source

Case Report: A case of synchronous multiple early gastric cancer with a microsatellite instability-high phenotype. [PDF]

Front Oncol
Wang X, Zhang Y, Fan G, Wu H, Qi X, Cui X, Zhou C.   +6 more
europepmc   +1 more source

Genetic Instability and Aberrant DNA Methylation in Chronic Hepatitis and Cirrhosis—A Comprehensive Study of Loss of Heterozygosity and Microsatellite Instability at 39 Loci and DNA Hypermethylation on 8 CpG Islands in Microdissected Specimens From Patients With Hepatocellular Carcinoma [PDF]

, 2000
Yutaka Kondo, Yae Kanai, Michiie Sakamoto, Masashi Mizokami, Ryuzo Ueda, Setsuo Hirohashi   +5 more
openalex   +1 more source

Harnessing nucleotide metabolism and immunity in cancer: a tumour microenvironment perspective

The FEBS Journal, Volume 292, Issue 9, Page 2155-2172, May 2025.
This review explores how changes in nucleotide metabolism affect the tumour microenvironment and immune responses in cancer. Here, we discuss the dual role of nucleotide metabolism in promoting cancer cell growth and shaping immune suppression. We highlight how therapies targeting nucleotide pathways can enhance immunotherapy efficacy, offering new ...
Hadil Suleiman, Alexandra Emerson, Peter M. Wilson, Karl A. Mulligan, Robert D. Ladner, Melissa J. LaBonte   +5 more
wiley   +1 more source