Results 231 to 240 of about 55,423 (289)

Characterization of Korean Colorectal Cancer Reveals Novel Driver Gene and Clinically Relevant Mutations

MedComm, Volume 7, Issue 1, January 2026.
This study utilizes whole‐genome sequencing of 197 paired samples to conduct mutational profiling of colorectal cancer (CRC) in Korean patients, identifying novel driver genes associated with recurrence. The research provides insights into oncogenic pathways and highlights clinically significant variants, emphasizing the importance of ethnic diversity ...
Junho Kang, Dong Min Lim, Young‐Joon Kim, Hyeran Shim, Tae‐You Kim, Kyu Joo Park, Sung‐Bum Kang, Chang Sik Yu, Jong Lyul Lee, Yeuni Yu, Hansong Lee, Eun Jung Kwon, Hyo Min Kim, Seongik Mun, Donghee Kwak, Hae Seul Lee, Hye Jin Heo, Eun Kyoung Kim, Seung Eun Baek, Jong‐Wook Park, Sung Uk Bae, Taeg Kyu Kwon, Dongjun Lee, Kihun Kim, Chang‐Kyu Oh, Dai Sik Ko, Sunghwan Cho, Hae Ryoun Park, Shin Kim, Yun Hak Kim   +29 more
wiley   +1 more source

Case Report: Failed response to anti-PD-1 immunotherapy in a colon cancer patient with high microsatellite instability. [PDF]

Front Oncol
Li R, Lin YP, Shen X, Guo JY, Zhang Y, Tang JD, Xie L, Hu FD.   +7 more
europepmc   +1 more source

Beyond PD‐1/PD‐L1: New Immune Checkpoints and Therapeutic Combinations in Cancer Immunotherapy

Medicine Bulletin, Volume 2, Issue 1, Page 61-93, January 2026.
ABSTRACT Recently, immune checkpoint inhibitors (ICIs), particularly PD‐1/PD‐L1 and CTLA‐4 inhibitors, have revolutionized cancer treatment, significantly improving survival rates for various malignancies. However, ICI therapies targeting single checkpoints on T cells still face numerous challenges, such as low response rates and post‐treatment ...
Yangyang Li, Zizhen Kang, Yanyun Du
wiley   +1 more source

Phenotypic attributes and survival in mismatch repair deficient/microsatellite instability-high colorectal carcinomas. [PDF]

World J Clin Oncol
Mehta A, Bansal D, Tripathi R, Anoop V.
europepmc   +1 more source

Effect of seed circulation systems on the spread and diversity of Xanthomonas phaseoli pv. manihotis infecting cassava crops of the Colombian Caribbean

PLANTS, PEOPLE, PLANET, Volume 8, Issue 1, Page 353-364, January 2026.
Cassava is a lifeline for millions of people across the tropics, but its productivity is at risk from a disease called Cassava Bacterial Blight (CBB). In this study, we explore how the everyday practices of farmers exchanging cassava cuttings—a long‐standing tradition—can shape how the disease spreads and evolves in the Colombian Caribbean.
Darío Pérez, Laurence Blondin, Sophie Caillon, Olivier Pruvost, Boris Szurek, Christian Vernière, Carlos A. Zárate‐Chaves, Anne Duputié   +7 more
wiley   +1 more source

Liver metastases and peritoneal metastases and response to checkpoint inhibitors in metastatic colorectal cancer with microsatellite instability

Marwan Fakih, Jaideep Sandhu, Xiaochen Li, Chongkai Wang   +3 more
openalex   +1 more source

Comprehensive Analysis of FOXO1 as a Tumour Suppressor Biomarker Related to Immune Infiltration and Cell Proliferation of Hepatocellular Carcinoma

IET Systems Biology, Volume 20, Issue 1, January/December 2026.
This article systematically analysed the expression patterns and functions of FOXO1 in various cancers through the integration of bioinformatics techniques and basic experiments and conducted indepth exploration in HCC, revealing that FOXO1 may affect the tumour immune microenvironment and regulate the proliferation ability of tumour cells.
Senzhe Xia, Xueqian Qin, Chenggeng Pan, Dingwei Fan, Daqing Yang   +4 more
wiley   +1 more source

Real-World Evaluation of Microsatellite Instability Detection via Targeted NGS Panels in Routine Molecular Diagnostics. [PDF]

Int J Mol Sci
Škerl P, Vogrič V, Stegel V, Šetrajčič Dragoš V, Blatnik O, Klančar G, Novaković S.   +6 more
europepmc   +1 more source

Mechanistic Investigation of Nitidine Chloride‐Mediated Anti‐Colorectal Cancer Activity: Centromere‐Associated Protein E Targeting via Integrated Molecular Dynamics, Spatial Transcriptomic and Single‐Cell Approaches

IET Systems Biology, Volume 20, Issue 1, January/December 2026.
Colorectal cancer (CRC) has high incidence and mortality, with conventional chemotherapy having severe side effects and drug resistance; traditional Chinese medicine‐derived nitidine chloride (NC) has anti‐tumour activity but unknown anti‐CRC mechanisms, whereas centromere‐associated protein E (CENPE), aberrantly expressed in malignancies, is a ...
Bin Li, Zhi‐Su Liu, Ke‐Jun Wu, Zong‐Yu Li, Wei Zhang, Hui Li, Rong‐Quan He, Di‐Yuan Qin, Jing‐Wen Ling, Jin‐Cheng Li, Gang Chen   +10 more
wiley   +1 more source

DNA polymerase epsilon-mutant colorectal cancers: Insights into non-exonuclease domain mutation variants, microsatellite instability status, and co-mutation profiles. [PDF]

World J Gastroenterol
Taskiran I, Orenay-Boyacioglu S, Boyacioglu O, Erdogdu IH, Culhaci N, Meteoglu I.   +5 more
europepmc   +1 more source