Results 241 to 250 of about 88,754 (292)

Dynamic Change of PD‐L2 on Circulating Plasma Extracellular Vesicles as a Predictor of Treatment Response in Melanoma Patients Receiving Anti‐PD‐1 Therapy

Journal of Extracellular Vesicles, Volume 14, Issue 4, April 2025.
ABSTRACT Immune checkpoint inhibitors (ICIs) have provided new hope for melanoma patients, however, not all patients benefit. Furthermore, ICI‐related therapies cause significant immune‐related adverse events that adversely affect patient outcomes. Therefore, there is a pressing need for reliable biomarkers to identify patients most likely to benefit ...
Linzi Sun, Xiaoting Wei, Qian Zhao, Lili Mao, Xue Bai, Caili Li, Junjie Gu, Yan Kong, Chuanliang Cui, Zhihong Chi, Xinan Sheng, Bin Lian, Xuan Wang, Siming Li, Xieqiao Yan, Bixia Tang, Li Zhou, Juan Li, Jun Guo, Lu Si, Jie Dai   +20 more
wiley   +1 more source

Microsatellite instability and mismatch repair protein deficiency: equal predictive markers? [PDF]

Pathol Oncol Res
Nádorvári ML, Lotz G, Kulka J, Kiss A, Tímár J.   +4 more
europepmc   +1 more source

Pancreatic Cancer: Pathogenesis and Clinical Studies

MedComm, Volume 6, Issue 4, April 2025.
Although the treatment landscape for cancer has evolved rapidly in recent years, progress has stagnated for pancreatic cancer (PC). PC includes multiple types, but pancreatic ductal adenocarcinoma (PDAC) accounts for >90% of cases. This review focuses on the molecular pathogenesis and different treatments for PDAC, hoping to propose future directions ...
Kexun Zhou, Yingping Liu, Chuanyun Tang, Hong Zhu   +3 more
wiley   +1 more source

Association between microsatellite instability status, clinicopathological features and mitochondrial DNA amplification in patients with colorectal cancer. [PDF]

Oncol Lett
Lu J, Tan H, Guo T, Chen X, Tong Z.
europepmc   +1 more source

Comprehensive characterization of micropapillary colorectal adenocarcinoma

The Journal of Pathology, Volume 265, Issue 4, Page 408-421, April 2025.
Abstract Micropapillary colorectal adenocarcinoma is a morphologic subtype of colorectal cancer (CRC) with insufficiently characterized prognostic significance and biological features. We analyzed the histopathological, immunological, and prognostic features of micropapillary adenocarcinoma in two independent CRC cohorts (N = 1,876).
Ville K Äijälä, Jouni Härkönen, Tuomo Mantere, Hanna Elomaa, Päivi Sirniö, Vesa‐Matti Pohjanen, Onni Sirkiä, Henna Karjalainen, Meeri Kastinen, Vilja V Tapiainen, Sara A Väyrynen, Petri Pölönen, Maarit Ahtiainen, Olli Helminen, Erkki‐Ville Wirta, Jukka Rintala, Sanna Meriläinen, Juha Saarnio, Tero Rautio, Katri Pylkäs, Toni T Seppälä, Jan Böhm, Jukka‐Pekka Mecklin, Anne Tuomisto, Markus J Mäkinen, Juha P Väyrynen   +25 more
wiley   +1 more source

Comprehensive Analysis of Microsatellite Instability in Canine Cancers: Implications for Comparative Oncology and Personalized Veterinary Medicine. [PDF]

Animals (Basel)
Mazzone E, Aresu L.
europepmc   +1 more source

Early colorectal cancer diagnosis: A novel methylated stool DNA model enhanced the diagnostic efficiency

United European Gastroenterology Journal, Volume 13, Issue 3, Page 402-415, April 2025.
Abstract Background Methylated stool DNA (sDNA) is a reliable noninvasive biomarker for early colorectal cancer (CRC) diagnosis. However, there are barely any diagnostic panels that can achieve both a sensitivity and specificity exceeding 90% simultaneously.
Peng Yun, Kamila Kulaixijiang, Jiang Pan, Luping Yang, Nengzhuang Wang, Zheng Xu, Yaodong Zhang, Haifang Cai, Zi‐Ye Zhao, Min Zhu, Hongli Yan   +10 more
wiley   +1 more source

Complete remission following pembrolizumab in a man with mCRPC with both microsatellite instability and BRCA2 mutation. [PDF]

Oncologist
Moore C, Naraine I, Zhang T.
europepmc   +1 more source

Loss of O6‐Methylguanine‐DNA Methyltransferase Protein Expression by Immunohistochemistry Is Associated With Response to Capecitabine and Temozolomide in Neuroendocrine Neoplasms

World Journal of Surgery, Volume 49, Issue 4, Page 964-972, April 2025.
Mark G. Evans, Joanne Xiu, Sourat Darabi, Anthony Crymes, Adam Bedeir, David A. Bryant, Matthew J. Oberley, Michael J. Demeure. ABSTRACT Background A recent prospective phase II study (ECOG‐ACRIN E2211) demonstrated that MGMT deficiency was associated with a significant response to capecitabine and temozolomide (CAPTEM) in pancreatic neuroendocrine ...
Mark G. Evans, Joanne Xiu, Sourat Darabi, Anthony Crymes, Adam Bedeir, David A. Bryant, Matthew J. Oberley, Michael J. Demeure   +7 more
wiley   +1 more source

PD‐L1 Scoring Models for Non‐Small Cell Lung Cancer in China: Current Status, AI‐Assisted Solutions and Future Perspectives

Thoracic Cancer, Volume 16, Issue 7, April 2025.
Although AI has shown promise in increasing the accuracy of PD‐L1 scoring in NSCLC, the technology is relatively new, and several technological challenges must be addressed. ABSTRACT Immunotherapy has revolutionized the diagnosis and treatment model for patients with advanced non‐small cell lung cancer (NSCLC).
Ziling Huang, Shen Wang, Jiansong Zhou, Haiquan Chen, Yuan Li   +4 more
wiley   +1 more source