Results 241 to 250 of about 55,423 (289)

Comparative Analysis of a Dual DNA–RNA Panel and a DNA‐Only Panel for Sarcoma: Real‐World Data From a Nationwide Genomic Database

Cancer Science, Volume 117, Issue 1, Page 156-168, January 2026.
Dual DNA–RNA panel with matched tumor–normal testing may improve diagnostic accuracy and inform treatment decisions in the routine clinical management of sarcoma. ABSTRACT Next‐generation sequencing‐based comprehensive cancer genomic profiling is promising in cancer management; however, most studies rely on tumor‐only DNA panels from single ...
Eiji Nakata, Kiichiro Ninomiya, Tatsunori Osone, Daisuke Ennishi, Shuta Tomida, Tomohiro Fujiwara, Toshiyuki Kunisada, Mashu Futagawa, Akira Hirasawa, Shinichi Toyooka, Toshifumi Ozaki   +10 more
wiley   +1 more source

Novel Methylation‐Based Model for Accurate Diagnosis of Upper Mediastinal Lymph Node Metastasis in Esophagogastric Junction Adenocarcinoma

Cancer Science, Volume 117, Issue 1, Page 169-180, January 2026.
DNA methylation‐based diagnostic model enables accurate, noninvasive identification of upper mediastinal lymph node metastasis and may guide personalized treatment strategies for patients with esophagogastric junction adenocarcinoma. ABSTRACT Even after surgical resection, the prognosis is poor for patients with esophagogastric junction adenocarcinoma ...
Yudai Higuchi, Katsutoshi Shoda, Suguru Maruyama, Yoshihiko Kawaguchi, Takaomi Ozawa, Hiroto Tanaka, Takashi Nakayama, Koichi Matsuoka, Ryo Saito, Wataru Izumo, Koichi Takiguchi, Kensuke Shiraishi, Shinji Furuya, Hidetake Amemiya, Daisuke Ichikawa   +14 more
wiley   +1 more source

Mutation and Microsatellite Instability (MSI) Affect the Differential Gene Expression of Folic Acid and 5-Flourouracil Metabolism-Related Genes in Colorectal Carcinoma. [PDF]

Curr Oncol
Islam MR, Jasmine F, Vasiljevs D, Raza M, Almazan A, Ahsan H, Kibriya MG.   +6 more
europepmc   +1 more source

ZNF282 Promotes Colorectal Cancer Progression Possibly via E2F1 Activation

Cancer Science, Volume 117, Issue 1, Page 90-104, January 2026.
ZNF282 is a zinc finger protein overexpressed in colorectal cancer that facilitates tumor progression by promoting cell cycle progression via E2F1 activation. Our study demonstrates that ZNF282 expression is associated with poor prognosis and may serve as a novel prognostic biomarker and therapeutic target. ABSTRACT Colorectal cancer (CRC) is a leading
Tadashi Abe, Takaaki Masuda, Taro Tobo, Masahiro Hashimoto, Yusuke Nakano, Hideyuki Saito, Takashi Ofuchi, Tomohiko Ikehara, Akinori Tsujimoto, Takafumi Nakano, Katsushi Dairaku, Junichi Takahashi, Kensuke Koike, Koto Kawata, Yuki Ando, Kiyotaka Hosoda, Takanari Tatsumi, Kosuke Hirose, Satoshi Higuchi, Hajime Otsu, Yusuke Yonemura, Ken Eto, Toru Ikegami, Koshi Mimori   +23 more
wiley   +1 more source

MOLECULAR ANALYSIS OF MICROSATELLITE INSTABILITY IN HEREDITARY NON POLYPOSIS COLON CARCINOMA PATIENTS FROM NORTH-EAST IRAN [PDF]

, 2009
Hamid Galehdari, Aazam Ahmadi Shadmehri, Kalantar Mahmoud, Ali Mohammad Foroughmand, Rasekh A.A.R.   +4 more
openalex  

A Robust Immunohistochemistry‐Based Classification for BRAF V600E‐Mutant Colorectal Cancer With Clinical Implications

Cancer Science, Volume 117, Issue 1, Page 246-256, January 2026.
This study develops an immunohistochemistry (IHC)‐based classification system for BRAF V600E‐mutant colorectal cancer, enabling practical stratification into iBM1 and iBM2 subtypes using CD8 and ARHGEF17 markers. The IHC‐defined subtypes demonstrated concordance with transcriptomic BM1/BM2 classifications and reflected distinct molecular and immune ...
Chao Liu, Yuli Ruan, Tong Wu, Xindi Luan, Yue Ma, Hong Wang, Tianjiao Dang, Yiwen Ou, Bojun Wang, Chunhui Zhang, Hongxue Meng, Yanqiao Zhang   +11 more
wiley   +1 more source

Prognostic Biomarker of Fertility‐Preserving Hormonal Therapy Based on Multigene Panel Testing for Endometrial Cancer

Cancer Science, Volume 117, Issue 1, Page 236-245, January 2026.
We identified prognostic biomarkers that predict treatment outcomes in patients receiving fertility‐preserving high‐dose medroxyprogesterone acetate (MPA) therapy through comprehensive multigene panel testing. ABSTRACT In this study, we identified prognostic biomarkers that predict treatment outcome in patients receiving fertility‐preserving high‐dose ...
Takuro Hirano, Kensuke Sakai, Takuma Yoshimura, Tatsuyuki Chiyoda, Kohei Nakamura, Eriko Aimono, Miho Kawaida, Hiroshi Nishihara, Nobuyuki Susumu, Daisuke Aoki, Wataru Yamagami   +10 more
wiley   +1 more source

Machine learning-based radiomics approach assessing preoperative non-contrast CT for microsatellite instability prediction in colon cancer. [PDF]

Front Physiol
Ren D, Wang Y, Chen L, He J, Shen T.
europepmc   +1 more source

A Combinatorial Effect of Immune Checkpoint Inhibitors and CD40 Agonistic Antibody in Murine Pancreatic Cancer Model

Cancer Science, Volume 117, Issue 1, Page 8-18, January 2026.
We established and extensively analyzed an organoid‐based mouse model that closely mimics human pancreatic ductal adenocarcinoma. Monotherapy with an immune checkpoint inhibitor cocktail or a CD40 agonist antibody showed minimal efficacy. However, combining both reagents produced a strong synergistic effect by enhancing anti‐tumor immunity.
Juri Ichikawa, Hiroshi Okuda, Kuniyuki Kawano, Shingo Kato, Shinya Sato, Ryo Kuroishikawa, Daisuke Kurotaki, Wataru Kawase, Haruka Yoshida, Yukihiko Hiroshima, Itaru Endo, Shin Maeda, Tomohiko Tamura   +12 more
wiley   +1 more source