Results 251 to 260 of about 88,754 (292)

Management of HER2-positive and microsatellite instability-high advanced gastric cancer: a case report. [PDF]

Int Cancer Conf J
Tamura T, Kanemasa Y, Nakamura S, Okuya T, Yagi Y, Matsuda S, Murata M, Endo K, Hara K, Okinaga H, Horiguchi SI, Seyama Y, Cho H, Shimoyama T.   +13 more
europepmc   +1 more source

EpigenPlot: An interactive web platform for DNA methylation‐based biomarker and drug target discovery in colorectal cancer

British Journal of Pharmacology, Volume 182, Issue 7, Page 1452-1465, April 2025.
Abstract Background and Purpose Genome‐wide methylation studies have significantly advanced our understanding of colorectal adenocarcinoma progression and biomarker discovery. Aberrant DNA methylation plays a crucial role in gene expression regulation during cancer transformation, highlighting the need to identify differentially methylated regions ...
Dalma Müller, Balázs Győrffy
wiley   +1 more source

Comparison of Microsatellite Instability With Clinicopathologic Data in Patients With Colon Adenocarcinoma. [PDF]

Cureus
Cesmecioglu Karavin E, Sağnak Yılmaz Z, Yazici H, Ersoz S, Mungan S.   +4 more
europepmc   +1 more source

Genomic profiles of patients with skin melanoma in the era of immune checkpoint inhibitors

Cancer Science, Volume 116, Issue 4, Page 1107-1114, April 2025.
We investigated the genomic profiles of patients with skin melanoma who had received immune checkpoint inhibitors and explored associations with clinical features and outcomes via a large‐scale nationwide database in Japan (the C‐CAT database). Patients with multiple (two or more) liver metastases or brain metastases were more likely to have NOTCH3 or ...
Yao Liang, Osamu Maeda, Kazuki Nishida, Basile Chretien, Yuichi Ando   +4 more
wiley   +1 more source

Microsatellite instability and somatic gene variant profile in solid organ tumors. [PDF]

Arch Med Sci
Erdogdu IH, Orenay-Boyacioglu S, Boyacioglu O, Kahraman-Cetin N, Guler H, Turan M, Meteoglu I.   +6 more
europepmc   +1 more source

Identification of clinicopathological‐specific driver gene and genetic subtyping of colorectal cancer

Cancer Science, Volume 116, Issue 4, Page 1068-1081, April 2025.
This study analyzed targeted sequencing of 6530 patients with metastatic Chinese colorectal cancer (CRC), identifying 36 novel driver genes with subgroup‐specific implications, such as ERBB4 affecting only male CRC patient outcomes. Additionally, the study utilized network‐based stratification to categorize microsatellite stable (MSS) and unstable (MSI)
Jianjiong Li, Chunnian Wang, Changshun Yang, Hua Bao, Ningyou Li, Xianqiang Huang, Wei Gong, Xinyue Hong, Jiani C. Yin, Jiaohui Pang, Meifu Gan, Danping Yuan   +11 more
wiley   +1 more source

Genomic profiles and their associations with microsatellite instability status, tumor mutational burden, and programmed death ligand 1 expression in Chinese patients with colorectal cancer. [PDF]

J Gastrointest Oncol
Luo B, Liao M, Nie B, Yu Y, Yao Q.
europepmc   +1 more source

Mutation Analysis of TMB‐High Colorectal Cancer: Insights Into Molecular Pathways and Clinical Implications

Cancer Science, Volume 116, Issue 4, Page 1082-1093, April 2025.
Colorectal cancer (CRC) tumors with high tumor mutation burden (TMB) often exhibit distinct molecular features, including lower KRAS and higher BRAF mutation frequencies, microsatellite instability (MSI), and a mutational signature linked to the CpG island methylator phenotype (CIMP).
Yuko Chikaishi, Hiroshi Matsuoka, Eiji Sugihara, Mayu Takeda, Makoto Sumitomo, Seiji Yamada, Gaku Inaguma, Yusuke Omura, Yeongcheol Cheong, Yosuke Kobayashi, Masaya Nakauchi, Junichiro Hiro, Koji Masumori, Koki Otsuka, Hiroshi Nishihara, Koichi Suda, Hideyuki Saya, Tetsuya Takimoto   +17 more
wiley   +1 more source

Mutations in Mismatch Repair Genes and Microsatellite Instability Status in Pancreatic Cancer. [PDF]

Cancers (Basel)
Emelyanova M, Ikonnikova A, Pushkov A, Pudova E, Krasnov G, Popova A, Zhanin I, Khomich D, Abramov I, Tjulandin S, Gryadunov D, Pokataev I.   +11 more
europepmc   +1 more source