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Microsatellite instability in sarcomas [PDF]
Annals of Surgical Oncology, 1998 Microsatellite instability (MIN) has been studied in a variety of carcinomas and gynecologic sarcomas, but never in musculoskeletal sarcomas.We evaluated 16 skeletal and soft tissue sarcomas at nine genetic loci from chromosomal regions 1q, 5q, 7q, 12p, 13q, 17p, 19q, and two at 11p--all potential regions of interest regarding musculoskeletal sarcomas ...
Stephanie S. Martin +4 more
openaire +3 more sources
Testing for lynch syndrome in people with endometrial cancer using immunohistochemistry and microsatellite instability-based testing strategies – a systematic review of test accuracy [PDF]
, 2021 Background Lynch syndrome is an inherited genetic condition that is associated with an increased risk of cancer, including endometrial and colorectal cancer.
Al-Khudairy, Lena +6 more
core +2 more sources
Microsatellite instability: a review of what the oncologist should know
Cancer Cell International, 2020 The patients with high microsatellite instability (MSI-H)/mismatch repair deficient (dMMR) tumors recently have been reported that can benefit from immunotherapy, and MSI can be used as a genetic instability of a tumor detection index.
Kai Li +4 more
semanticscholar +1 more source
Cancer Science, 2021 Microsatellite instability‐high (MSI‐H) is an important biomarker for predicting the effect of immune checkpoint inhibitors (ICIs) on advanced solid tumors.
K. Akagi +6 more
semanticscholar +1 more source
IJU Case Reports, 2022 Introduction Prostate cancer with a microsatellite instability‐high or mismatch repair‐deficient status is not common. Few reports of the response to pembrolizumab in metastatic castration‐resistant prostate cancer in a real‐world setting have been ...
Takumi Kageyama +7 more
doaj +1 more source
Microsatellite instability-high gastric cancer patients may benefit from adjuvant radiotherapy
Libri Oncologici, 2023 Gastric cancer remains one of the deadliest types of cancer despite the improvements in therapy regimens. The knowledge about specific molecular and histopathologic features of gastric tumors leads toward targeted therapy protocols.
Suzana Janković +6 more
doaj +1 more source
Frontiers in Oncology, 2022 BackgroundThe detection of microsatellite instability in urologic cancers is rare, especially in metastatic, castration-resistant prostate cancer with neuroendocrine differentiation.Case presentationThis is a case of a 66-year-old Asian male patient with
Tsukasa Yoshida +8 more
doaj +1 more source
Microsatellite instability/mismatch repair deficiency and activation of the Wnt/beta-catenin signaling pathway in gastric adenocarcinoma of the fundic gland A case report [PDF]
, 2022 Rationale: Gastric adenocarcinoma of the fundic gland is a rare, well-differentiated variant of gastric adenocarcinoma, which has been proposed as a novel disease entity.
Yang, Guang
core +1 more source
Microsatellite instability in colorectal cancer [PDF]
Radiology and Oncology, 2011 Colorectal cancer (CRC) is the third most common cancer in the world. In 75% CRC develops sporadically, in 25% hereditary or as a consequence of inflammatory bowel disease. CRC carcinogenesis develops over many years. The cause of CRC in 85% is chromosomal instability (CIN) and in 15% microsatellite instability (MSI-H), where hereditary nonpolyposis ...
Horvat, Matej, Štabuc, Borut
openaire +4 more sources
Biology Direct, 2022 Background Historically, the molecular classification of colorectal cancer (CRC) was based on the global genomic status, which identified microsatellite instability in mismatch repair (MMR) deficient CRC, and chromosomal instability in MMR proficient CRC.
Pasquale Sibilio +4 more
doaj +1 more source