Results 21 to 30 of about 91,099 (324)

Relationship between protein biomarkers of chemotherapy response and microsatellite status, tumor mutational burden and PD-L1 expression in cancer patients. [PDF]

, 2020
Chemotherapy and checkpoint inhibitor immunotherapies are increasingly used in combinations. We determined associations between the presence of anti-PD-1/PD-L1 therapeutic biomarkers and protein markers of potential chemotherapy response.
Arguello, David, Barkauskas, Donald A, Gatalica, Zoran, Kurzrock, Razelle, Nikanjam, Mina, Swensen, Jeff   +5 more
core   +2 more sources

Analysis of microsatellite instability in medulloblastoma [PDF]

Neuro-Oncology, 2009
Medulloblastoma is the most common malignant brain tumor in children. The presence of microsatellite instability (MSI) in brain tumors, particularly medulloblastomas, has not been properly addressed. The aim of the present study was to evaluate the role of MSI in medulloblastoma carcinogenesis. MSI status was determined in 36 patients using a pentaplex
Pereira, Marta Sofia Carvalho Ribeiro Viana, Almeida, Inês, Sousa, Sónia, Mahler-Araújo, Bethânia, Seruca, Raquel, Pimentel, José, Reis, R. M.   +6 more
openaire   +4 more sources

Pembrolizumab for a patient with metastatic castration‐resistant prostate cancer with microsatellite instability‐high

IJU Case Reports, 2020
Introduction We report the case of a patient with metastatic castration‐resistant prostate cancer with microsatellite instability‐high who was treated with pembrolizumab after cabazitaxel administration.
Motohiro Fujiwara, Yoshinobu Komai, Takeshi Yuasa, Noboru Numao, Shinya Yamamoto, Iwao Fukui, Junji Yonese   +6 more
doaj   +1 more source

Prognostic value of SLC4A4 and its correlation with the microsatellite instability in colorectal cancer

Frontiers in Oncology, 2023
ObjectiveTo explore new biomarkers related to microsatellite instability in order to better predict prognosis and guide medication.MethodsThe “limma” R package was used to identify differentially expressed genes in GSE24514, and then weighted correlation
Shaorui Rui, Dong Wang, Yong Huang, Jingyun Xu, Hailang Zhou, Hailang Zhou, Hesong Zhang   +6 more
doaj   +1 more source

Microsatellite instability in colorectal cancer

EXCLI journal, 2018
EXCLI Journal; 17:Doc159; ISSN 1611 ...
Shahin Behrouz Sharif, Shahin Behrouz Sharif, Jafar Nouri Nojadeh, Ebrahim Sakhinia   +3 more
openaire   +8 more sources

Microsatellite instability induced mutations in DNA repair genes CtIP and MRE11 confer hypersensitivity to poly (ADP-ribose) polymerase inhibitors in myeloid malignancies

Haematologica, 2013
Inactivation of the DNA mismatch repair pathway manifests as microsatellite instability, an accumulation of mutations that drives carcinogenesis. Here, we determined whether microsatellite instability in acute myeloid leukemia and myelodysplastic ...
Terry J. Gaymes, Azim M. Mohamedali, Miranda Patterson, Nazia Matto, Alexander Smith, Austin Kulasekararaj, Rajani Chelliah, Nicola Curtin, Farzin Farzaneh, Sydney Shall, Ghulam J. Mufti   +10 more
doaj   +1 more source

Extended microsatellite analysis in microsatellite stable, MSH2 and MLH1 mutation-negative HNPCC patients: Genetic reclassification and correlation with clinical features [PDF]

, 2004
Background: Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant disorder predisposing to predominantly colorectal cancer (CRC) and endometrial cancer frequently due to germline mutations in DNA mismatch repair (MMR) genes, mainly ...
Baretton, G., Daum, J., Gross, M., Holinski-Feder, E., Kopp, R., Lohse, P., Muders, M., Mussack, T., Müller-Koch, Y., Schiemann, Uwe   +9 more
core   +1 more source

Microsatellite Instability in Yeast: Dependence on the Length of the Microsatellite [PDF]

Genetics, 1997
One of the most common microsatellites in eukaryotes consists of tandem arrays [usually 15-50 base pairs (bp) in length] of the dinucleotide GT. We examined the rates of instability for poly GT tracts of 15, 33, 51, 99 and 105 bp in wild-type and mismatch repair-deficient strains of Saccharomyces cerevisiae. Rates of instability increased more than two
Monika Wierdl, Margaret Dominska, Thomas D. Petes   +2 more
openaire   +2 more sources

The degree of microsatellite instability predicts response to PD-1 blockade immunotherapy in mismatch repair-deficient/microsatellite instability-high colorectal cancers

Experimental Hematology & Oncology, 2021
The development of programmed cell death-1 inhibitor (PD-1) has shed light on the treatment of tumors with deficiencies in DNA mismatch repair system or microsatellite instability (dMMR/MSI). However, predicting the subset in this group that will benefit
Qiao-Xuan Wang, Chun-Hua Qu, Yuan-Hong Gao, Pei-Rong Ding, Jing-Ping Yun, Dan Xie, Mu-Yan Cai   +6 more
doaj   +1 more source

Role of microsatellite instability in colon cancer

Тазовая хирургия и онкология, 2015
Coloncancer is among leading causes of cancer morbidity and mortality both inRussiaand worldwide. Development of molecular biology lead to decoding of carcinogenesis and tumor progression mechanisms.
M. Yu. Fedyanin, A. A. Tryakin, S. A. Tjulandin   +2 more
doaj   +1 more source