Results 21 to 30 of about 55,423 (289)

Microsatellite instability induced mutations in DNA repair genes CtIP and MRE11 confer hypersensitivity to poly (ADP-ribose) polymerase inhibitors in myeloid malignancies

Haematologica, 2013
Inactivation of the DNA mismatch repair pathway manifests as microsatellite instability, an accumulation of mutations that drives carcinogenesis. Here, we determined whether microsatellite instability in acute myeloid leukemia and myelodysplastic ...
Terry J. Gaymes, Azim M. Mohamedali, Miranda Patterson, Nazia Matto, Alexander Smith, Austin Kulasekararaj, Rajani Chelliah, Nicola Curtin, Farzin Farzaneh, Sydney Shall, Ghulam J. Mufti   +10 more
doaj   +1 more source

Prognostic value of SLC4A4 and its correlation with the microsatellite instability in colorectal cancer

Frontiers in Oncology, 2023
ObjectiveTo explore new biomarkers related to microsatellite instability in order to better predict prognosis and guide medication.MethodsThe “limma” R package was used to identify differentially expressed genes in GSE24514, and then weighted correlation
Shaorui Rui, Dong Wang, Yong Huang, Jingyun Xu, Hailang Zhou, Hailang Zhou, Hesong Zhang   +6 more
doaj   +1 more source

The degree of microsatellite instability predicts response to PD-1 blockade immunotherapy in mismatch repair-deficient/microsatellite instability-high colorectal cancers

Experimental Hematology & Oncology, 2021
The development of programmed cell death-1 inhibitor (PD-1) has shed light on the treatment of tumors with deficiencies in DNA mismatch repair system or microsatellite instability (dMMR/MSI). However, predicting the subset in this group that will benefit
Qiao-Xuan Wang, Chun-Hua Qu, Yuan-Hong Gao, Pei-Rong Ding, Jing-Ping Yun, Dan Xie, Mu-Yan Cai   +6 more
doaj   +1 more source

European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender

BJS (British Journal of Surgery), EarlyView., 2020
Recommendations for clinical and molecular identification of LS, surgical and endoscopic management of LS‐associated colorectal cancer and preventive measures for cancer were produced. The emphasis was on surgical and gastroenterological aspects of the cancer spectrum.
T. T. Seppälä, A. Latchford, I. Negoi, A. Sampaio Soares, R. Jimenez‐Rodriguez, L. Sánchez‐Guillén, D. G. Evans, N. Ryan, E. J. Crosbie, M. Dominguez‐Valentin, J. Burn, M. Kloor, M. von Knebel Doeberitz, F. J. B. van Duijnhoven, P. Quirke, J. R. Sampson, P. Møller, G. Möslein, on behalf of the European Hereditary Tumour Group (EHTG) and European Society of Coloproctology (ESCP)   +18 more
wiley   +1 more source

Role of microsatellite instability in colon cancer

Тазовая хирургия и онкология, 2015
Coloncancer is among leading causes of cancer morbidity and mortality both inRussiaand worldwide. Development of molecular biology lead to decoding of carcinogenesis and tumor progression mechanisms.
M. Yu. Fedyanin, A. A. Tryakin, S. A. Tjulandin   +2 more
doaj   +1 more source

Profiling diverse sequence tandem repeats in colorectal cancer reveals co-occurrence of microsatellite and chromosomal instability involving Chromosome 8

Genome Medicine, 2021
We developed a sensitive sequencing approach that simultaneously profiles microsatellite instability, chromosomal instability, and subclonal structure in cancer. We assessed diverse repeat motifs across 225 microsatellites on colorectal carcinomas.
GiWon Shin, Stephanie U. Greer, Erik Hopmans, Susan M. Grimes, HoJoon Lee, Lan Zhao, Laura Miotke, Carlos Suarez, Alison F. Almeda, Sigurdis Haraldsdottir, Hanlee P. Ji   +10 more
doaj   +1 more source

Genetic changes of MLH1 and MSH2 genes could explain constant findings on microsatellite instability in intracranial meningioma

Tumor Biology, 2017
Postreplicative mismatch repair safeguards the stability of our genome. The defects in its functioning will give rise to microsatellite instability. In this study, 50 meningiomas were investigated for microsatellite instability. Two major mismatch repair
Nives Pećina-Šlaus, Anja Kafka, Anja Bukovac, Tomislav Vladušić, Davor Tomas, Reno Hrašćan   +5 more
doaj   +1 more source

Medullary colonic carcinoma with microsatellite instability has lower survival compared with conventional colonic adenocarcinoma with microsatellite instability

Gastroenterology Review, 2016
Introduction: Colorectal medullary carcinoma (MC) is a rare subtype of poorly differentiated adenocarcinoma (PDA) with unclear prognostic significance.
Miguel A. Gómez-Álvarez, Leonardo S. Lino-Silva, Rosa A. Salcedo-Hernández, Alejandro Padilla-Rosciano, Erika B. Ruiz-García, Horacio N. López-Basave, German Calderillo-Ruiz, José M. Aguilar-Romero, Jorge A. Domínguez-Rodríguez, Ángel Herrera-Gómez, Abelardo Meneses-García   +10 more
doaj   +1 more source

Association between c-type lectin-like receptor 2 and microsatellite instability in colorectal cancer: a cross-sectional study

BMC Cancer, 2022
Background As a transmembrane protein, C-type lectin-like receptor 2 (CLEC-2) is mainly expressed on platelets and released into plasma after platelet activation. Activated platelets participate in the regulation of innate immune cells.
Xin Zhang, Jia-rui Yuan, Xin Wang, Shuang Fu, Rui-tao Wang, Guang-yu Wang   +5 more
doaj   +1 more source

Mismatch repair-deficient crypt foci in Lynch syndrome--molecular alterations and association with clinical parameters. [PDF]

PLoS ONE, 2015
Lynch syndrome is caused by germline mutations of DNA mismatch repair (MMR) genes, most frequently MLH1 and MSH2. Recently, MMR-deficient crypt foci (MMR-DCF) have been identified as a novel lesion which occurs at high frequency in the intestinal mucosa ...
Laura Staffa, Fabian Echterdiek, Nina Nelius, Axel Benner, Wiebke Werft, Bernd Lahrmann, Niels Grabe, Martin Schneider, Mirjam Tariverdian, Magnus von Knebel Doeberitz, Hendrik Bläker, Matthias Kloor   +11 more
doaj   +1 more source