Results 1 to 10 of about 55,724 (327)

Impeding Transcription of Expanded Microsatellite Repeats by Deactivated Cas9. [PDF]

Mol Cell, 2017
SummaryTranscription of expanded microsatellite repeats is associated with multiple human diseases, including myotonic dystrophy, Fuchs’ endothelial corneal dystrophy, andC9orf72-ALS/FTD. Eliminating or reducing production of RNA and proteins arising from these expanded loci holds therapeutic benefit.
Pinto BS, Saxena T, Oliveira R, Méndez-Gómez HR, Cleary JD, Denes LT, McConnell O, Arboleda J, Xia G, Swanson MS, Wang ET.   +10 more
europepmc   +9 more sources

Functional and immunological relevance of Anaplasma marginale major surface protein 1a sequence and structural analysis. [PDF]

PLoS ONE, 2013
Bovine anaplasmosis is caused by cattle infection with the tick-borne bacterium, Anaplasma marginale. The major surface protein 1a (MSP1a) has been used as a genetic marker for identifying A.
Alejandro Cabezas-Cruz, Lygia M F Passos, Katarzyna Lis, Rachel Kenneil, James J Valdés, Joana Ferrolho, Miray Tonk, Anna E Pohl, Libor Grubhoffer, Erich Zweygarth, Varda Shkap, Mucio F B Ribeiro, Agustín Estrada-Peña, Katherine M Kocan, José de la Fuente   +14 more
doaj   +20 more sources

Genome-wide functional perturbation of human microsatellite repeats using engineered zinc finger transcription factors [PDF]

Cell Genomics, 2022
Summary: Repeat elements can be dysregulated at a genome-wide scale in human diseases. For example, in Ewing sarcoma, hundreds of inert GGAA repeats can be converted into active enhancers when bound by EWS-FLI1.
Y. Esther Tak, Gaylor Boulay, Lukuo Lee, Sowmya Iyer, Nicholas T. Perry, Hayley T. Schultz, Sara P. Garcia, Liliane Broye, Joy E. Horng, Shruthi Rengarajan, Beverly Naigles, Angela Volorio, Jeffry D. Sander, Jingyi Gong, Nicolò Riggi, J. Keith Joung, Miguel N. Rivera   +16 more
doaj   +2 more sources

Abundant variation in microsatellites of the parasitic nematode Trichostrongylus tenuis and linkage to a tandem repeat [PDF]

, 2006
An understanding of how genes move between and within populations of parasitic nematodes is important in combating the evolution and spread of anthelmintic resistance.
P. Johnson, Lucy M.I. Webster, Aileen Adam, Robert Buckland, Deborah A. Dawson, Lukas F. Keller   +5 more
openalex   +4 more sources

Development and characterization of microsatellite markers for Chaeturichthys stigmatias (Actinopterygii: Gobiiformes: Gobiidae) based on restriction site-associated DNA sequencing (RAD-seq) [PDF]

Acta Ichthyologica et Piscatoria, 2022
Chaeturichthys stigmatias Richardson, 1844, a fish species of the family Gobiidae, is an offshore warm-temperate fish species and a dominant component of estuarine ecosystems.
Bingjie Chen, Yu Pan, Jian Zheng, Chenyu Song, Na Song   +4 more
doaj   +3 more sources

Genomic microsatellite characteristics analysis of Dysomma anguillare (Anguilliformes, Dysommidae), based on high-throughput sequencing technology [PDF]

Biodiversity Data Journal, 2023
Microsatellite loci were screened from the genomic data of Dysomma anguillare and their composition and distribution were analysed by bioinformatics for the first time.
Ziyan Zhu, Yuping Liu, Shufei Zhang, Sige Wang, Tianyan Yang   +4 more
doaj   +3 more sources

Fast and cost-effective mining of microsatellite markers using NGS technology: an example of a Korean water deer Hydropotes inermis argyropus. [PDF]

PLoS ONE, 2011
BACKGROUND: Microsatellites, a special class of repetitive DNA sequence, have become one of the most popular genetic markers for population/conservation genetic studies.
Jeong-Nam Yu, Changman Won, Jumin Jun, Youngwoon Lim, Myounghai Kwak   +4 more
doaj   +1 more source

Genome-wide characterization of microsatellite DNA in fishes: survey and analysis of their abundance and frequency in genome-specific regions

BMC Genomics, 2021
Background Microsatellite repeats are ubiquitous in organism genomes and play an important role in the chromatin organization, regulation of gene activity, recombination and DNA replication. Although microsatellite distribution patterns have been studied
Yi Lei, Yu Zhou, Megan Price, Zhaobin Song   +3 more
doaj   +1 more source

Genome-wide distribution and organization of microsatellites in plants: an insight into marker development in Brachypodium. [PDF]

PLoS ONE, 2011
Plant genomes are complex and contain large amounts of repetitive DNA including microsatellites that are distributed across entire genomes. Whole genome sequences of several monocot and dicot plants that are available in the public domain provide an ...
Humira Sonah, Rupesh K Deshmukh, Anshul Sharma, Vinay P Singh, Deepak K Gupta, Raju N Gacche, Jai C Rana, Nagendra K Singh, Tilak R Sharma   +8 more
doaj   +1 more source

Microsatellite repeat mapping shows inner chromosomal diversification in highly conserved karyotypes of Asian cyprinid fishes. [PDF]

Comp Cytogenet
Buasriyot P, Supiwong W, Muanglen N, Donbundit N, Ditcharoen S, Chumpol P, Saenjundaeng P, Tongnunui S, Arunsang S, Thongnetr W, Juntharat S, Seetapan K, Liehr T, Cioffi MB, Rab P, Tanomtong A.   +15 more
europepmc   +2 more sources