Impeding Transcription of Expanded Microsatellite Repeats by Deactivated Cas9. [PDF]
Mol Cell, 2017 SummaryTranscription of expanded microsatellite repeats is associated with multiple human diseases, including myotonic dystrophy, Fuchs’ endothelial corneal dystrophy, andC9orf72-ALS/FTD. Eliminating or reducing production of RNA and proteins arising from these expanded loci holds therapeutic benefit.
Pinto BS +10 more
europepmc +7 more sources
Functional and immunological relevance of Anaplasma marginale major surface protein 1a sequence and structural analysis. [PDF]
PLoS ONE, 2013 Bovine anaplasmosis is caused by cattle infection with the tick-borne bacterium, Anaplasma marginale. The major surface protein 1a (MSP1a) has been used as a genetic marker for identifying A.
Alejandro Cabezas-Cruz +14 more
doaj +20 more sources
Genome-wide functional perturbation of human microsatellite repeats using engineered zinc finger transcription factors [PDF]
Cell Genomics, 2022 Summary: Repeat elements can be dysregulated at a genome-wide scale in human diseases. For example, in Ewing sarcoma, hundreds of inert GGAA repeats can be converted into active enhancers when bound by EWS-FLI1.
Y. Esther Tak +16 more
doaj +2 more sources
Chromosomal distribution of microsatellite repeats in Amazon cichlids genome (Pisces, Cichlidae). [PDF]
Comp Cytogenet, 2015 Schneider CH +5 more
europepmc +3 more sources
Development and characterization of microsatellite markers for Chaeturichthys stigmatias (Actinopterygii: Gobiiformes: Gobiidae) based on restriction site-associated DNA sequencing (RAD-seq) [PDF]
Acta Ichthyologica et Piscatoria, 2022 Chaeturichthys stigmatias Richardson, 1844, a fish species of the family Gobiidae, is an offshore warm-temperate fish species and a dominant component of estuarine ecosystems.
Bingjie Chen +4 more
doaj +3 more sources
Genomic microsatellite characteristics analysis of Dysomma anguillare (Anguilliformes, Dysommidae), based on high-throughput sequencing technology [PDF]
Biodiversity Data Journal, 2023 Microsatellite loci were screened from the genomic data of Dysomma anguillare and their composition and distribution were analysed by bioinformatics for the first time.
Ziyan Zhu +4 more
doaj +3 more sources
Fast and cost-effective mining of microsatellite markers using NGS technology: an example of a Korean water deer Hydropotes inermis argyropus. [PDF]
PLoS ONE, 2011 BACKGROUND: Microsatellites, a special class of repetitive DNA sequence, have become one of the most popular genetic markers for population/conservation genetic studies.
Jeong-Nam Yu +4 more
doaj +1 more source
BMC Genomics, 2021 Background Microsatellite repeats are ubiquitous in organism genomes and play an important role in the chromatin organization, regulation of gene activity, recombination and DNA replication. Although microsatellite distribution patterns have been studied
Yi Lei +3 more
doaj +1 more source
Genome-wide distribution and organization of microsatellites in plants: an insight into marker development in Brachypodium. [PDF]
PLoS ONE, 2011 Plant genomes are complex and contain large amounts of repetitive DNA including microsatellites that are distributed across entire genomes. Whole genome sequences of several monocot and dicot plants that are available in the public domain provide an ...
Humira Sonah +8 more
doaj +1 more source
Journal of Horticultural Sciences, 2023 The fruit-bearing medicinal tree, Garcinia morella, grows in the tropical rain forests of India’s Western Ghats, Indo-Chinese Himalayan regions and Sri Lanka. Its fruit rinds are used as a garnish and in seasoning during food preparation.
K V Ravishankar +8 more
doaj +1 more source