Microsatellite repeat instability and neurological disease [PDF]
BioEssays, 2009 AbstractOver 20 unstable microsatellite repeats have been identified as the cause of neurological disease in humans. The repeat nucleotide sequences, their location within the genes, the ranges of normal and disease‐causing repeat length and the clinical outcomes differ.
Judith R. Brouwer +2 more
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Characterization of Duck Microsatellite Repeat Sequences
Japan Agricultural Research Quarterly: JARQ, 2001 We cloned duck microsatellite repeat sequences from genomic DNA of an Indonesian native duck to evaluate the genetic relationships among native breeds of duck. A (CA) n - enriched library was constructed using the method of Takahashi et al. (1996) with modifications. In the library, 8.3% of the clones were CA-positive.
Hideaki Takahashi +4 more
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Frameshift mutations at coding mononucleotide repeat microsatellites in endometrial carcinoma with microsatellite instability [PDF]
Cancer, 2000 Microsatellite instability (MI) is a frequent occurrence in endometrioid carcinoma of the endometrium (EC). Several genes known to contain mononucleotide short tracts in their coding sequences (TGF-beta RII, IGFIIR, BAX, hMSH6, and hMSH3) are likely targets for mutations in these tumors.DNA from 24 patients with EC and MI was extracted from blood and ...
Lluís Catasús +6 more
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Discrepancy variation of dinucleotide microsatellite repeats in eukaryotic genomes [PDF]
Biological Research, 2009 To address whether there are differences of variation among repeat motif types and among taxonomic groups, we present here an analysis of variation and correlation of dinucleotide microsatellite repeats in eukaryotic genomes.
HUAN GAO +4 more
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Genomic microsatellite characteristics analysis of Dysomma anguillare (Anguilliformes, Dysommidae), based on high-throughput sequencing technology [PDF]
Biodiversity Data Journal, 2023 Microsatellite loci were screened from the genomic data of Dysomma anguillare and their composition and distribution were analysed by bioinformatics for the first time.
Ziyan Zhu +4 more
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RNA biology of disease-associated microsatellite repeat expansions [PDF]
Acta Neuropathologica Communications, 2017 Microsatellites, or simple tandem repeat sequences, occur naturally in the human genome and have important roles in genome evolution and function. However, the expansion of microsatellites is associated with over two dozen neurological diseases. A common denominator among the majority of these disorders is the expression of expanded tandem repeat ...
Kushal J. Rohilla, Keith T. Gagnon
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Fast and cost-effective mining of microsatellite markers using NGS technology: an example of a Korean water deer Hydropotes inermis argyropus. [PDF]
PLoS ONE, 2011 BACKGROUND: Microsatellites, a special class of repetitive DNA sequence, have become one of the most popular genetic markers for population/conservation genetic studies.
Jeong-Nam Yu +4 more
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No evidence of EMAST in whole genome sequencing data from 248 colorectal cancers [PDF]
, 2021 Microsatellite instability (MSI) is caused by defective DNA mismatch repair (MMR), and manifests as accumulation of small insertions and deletions (indels) in short tandem repeats of the genome. Another form of repeat instability, elevated microsatellite
Aaltonen, Lauri A. +14 more
core +1 more source
BMC Genomics, 2021 Background Microsatellite repeats are ubiquitous in organism genomes and play an important role in the chromatin organization, regulation of gene activity, recombination and DNA replication. Although microsatellite distribution patterns have been studied
Yi Lei +3 more
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Systematic microsatellite repeat expansion cloning and validation [PDF]
Human Genetics, 2020 Approximately 3% of the human genome is composed of short tandem repeat (STR) DNA sequence known as microsatellites, which can be found in both coding and non-coding regions. When associated with genic regions, expansion of microsatellite repeats beyond a critical threshold causes dozens of neurological repeat expansion disorders.
Kushal J. Rohilla +5 more
openaire +3 more sources