Results 11 to 20 of about 57,676 (330)
RNA Helicases in Microsatellite Repeat Expansion Disorders and Neurodegeneration [PDF]
Frontiers in Genetics, 2022 Short repeated sequences of 3−6 nucleotides are causing a growing number of over 50 microsatellite expansion disorders, which mainly present with neurodegenerative features. Although considered rare diseases in relation to the relatively low number of cases, these primarily adult-onset conditions, often debilitating and fatal in absence of a cure ...
Lydia M. Castelli +4 more
openalex +5 more sources
Discrepancy variation of dinucleotide microsatellite repeats in eukaryotic genomes [PDF]
Biological Research, 2009 To address whether there are differences of variation among repeat motif types and among taxonomic groups, we present here an analysis of variation and correlation of dinucleotide microsatellite repeats in eukaryotic genomes.
HUAN GAO +4 more
doaj +4 more sources
Systematic microsatellite repeat expansion cloning and validation [PDF]
Human Genetics, 2020 Approximately 3% of the human genome is composed of short tandem repeat (STR) DNA sequence known as microsatellites, which can be found in both coding and non-coding regions. When associated with genic regions, expansion of microsatellite repeats beyond a critical threshold causes dozens of neurological repeat expansion disorders.
Kushal J. Rohilla +5 more
openaire +2 more sources
Microsatellite repeat instability and neurological disease [PDF]
BioEssays, 2009 AbstractOver 20 unstable microsatellite repeats have been identified as the cause of neurological disease in humans. The repeat nucleotide sequences, their location within the genes, the ranges of normal and disease‐causing repeat length and the clinical outcomes differ.
Brouwer, JR (Jaap) +2 more
openaire +3 more sources
GTn Repeat Microsatellite Instability in Uterine Fibroids [PDF]
Frontiers in Genetics, 2019 Background: Type I collagen is a triple helix structure with two α1 and one α2 chains. Coordinated biosynthesis of α1 and α2 subunits is very important for tissue morphogenesis, growth, and repair. In contrast, abnormal deposition in response to proinflammatory cytokines is associated with organ dysfunction.
Bineta Kénémé +2 more
openaire +4 more sources
Hepatology, EarlyView., 2022 Phase 1b study of anlotinib combined with TQB2450 in pretreated advanced biliary tract cancer and biomarker analysis. Abstract Background and Aims We evaluated the efficacy and safety of the antiangiogenic tyrosine kinase inhibitor anlotinib plus TQB2450, a programmed death‐ligand 1 inhibitor in pretreated advanced biliary tract cancers (BTCs ...
Jun Zhou +13 more
wiley +1 more source
Compound Microsatellite Repeats: Practical and Theoretical Features [PDF]
Genome Research, 1999 Most linkage and population genetic studies that use microsatellites assume that the polymorphism observed at these loci is due simply to variation in the number of units of a single repeat. Variation is far more complex, however, for the numerous microsatellites that contain interruptions within the repeat or contain more than one type of repeat.
L N, Bull +2 more
openaire +2 more sources
Cellular and Molecular Gastroenterology and Hepatology, 2020 Background & Aims: Fifty percent of colorectal cancers show elevated microsatellite alterations at selected tetranucleotide repeats (EMAST) and are associated with inflammation, metastasis, and poor patient outcome.
Maide Ö. Raeker +2 more
doaj +1 more source
Functionally relevant microsatellites in sugarcane unigenes
BMC Plant Biology, 2010 Background Unigene sequences constitute a rich source of functionally relevant microsatellites. The present study was undertaken to mine the microsatellites in the available unigene sequences of sugarcane for understanding their constitution in the ...
Singh Nagendra K +6 more
doaj +1 more source
Isolation and identification of a new set of microsatellite loci from Ucides cordatus genome [PDF]
Archives of Biological Sciences, 2015 A new set of microsatellite loci (simple sequence repeats, SSRs) from the overexploited mangrove crab Ucides cordatus is described in this study. Microsatellite isolation used a highly simplified and inexpensive protocol based on (i) multiple ...
Araújo Erlane S. +4 more
doaj +1 more source