Results 21 to 30 of about 28,396 (290)
Sequence determinants of human microsatellite variability
BMC Genomics, 2009 Background Microsatellite loci are frequently used in genomic studies of DNA sequence repeats and in population studies of genetic variability. To investigate the effect of sequence properties of microsatellites on their level of variability we have ...
Jakobsson Mattias +3 more
doaj +1 more source
Microsatellite Instability Causes Repeat Expansion and WRN Dependence [PDF]
Cancer Discovery, 2020 Abstract Cells with MSI accumulate unstable, structure-forming (TA)n repeats resolvable by the helicase WRN.
openalex +2 more sources
Analyses of carnivore microsatellites and their intimate association with tRNA-derived SINEs
BMC Genomics, 2006 Background The popularity of microsatellites has greatly increased in the last decade on account of their many applications. However, little is currently understood about the factors that influence their genesis and distribution among and within species ...
Bosch Montserrat +3 more
doaj +1 more source
The accuracy, feasibility and challenges of sequencing short tandem repeats using next-generation sequencing platforms. [PDF]
PLoS ONE, 2014 To date we have little knowledge of how accurate next-generation sequencing (NGS) technologies are in sequencing repetitive sequences beyond known limitations to accurately sequence homopolymers.
Monika Zavodna +3 more
doaj +1 more source
PLoS ONE, 2020 Siberian wild rye (Elymus sibiricus L.), an allotetraploid species, is a potentially high-quality perennial forage crop native to temperate regions. We used fluorescently conjugated oligonucleotides, representing ten repetitive sequences, including 6 ...
Jihong Xie +4 more
doaj +1 more source
Clinical and mechanism research progress on short tandem repeat ⁃ related neuromuscular diseases
Chinese Journal of Contemporary Neurology and Neurosurgery, 2023 Short tandem repeat (STR) is a component of the human genome, the number of repeats of STR is prone to change during DNA replication, and when it exceeds a certain threshold, it will lead to the occurrence of diseases, most of which involve the nervous ...
WAN Ya‑lan +4 more
doaj +1 more source
BJS (British Journal of Surgery), EarlyView., 2020 Recommendations for clinical and molecular identification of LS, surgical and endoscopic management of LS‐associated colorectal cancer and preventive measures for cancer were produced. The emphasis was on surgical and gastroenterological aspects of the cancer spectrum.
T. T. Seppälä +18 more
wiley +1 more source
Microsatellite Expansion Diseases: Repeat Toxicity Found in Translation [PDF]
Neuron, 2017 Sellier et al. (2017) show that translation of expanded CGG repeats in fragile X-associated tremor/ataxia syndrome is initiated at an upstream ACG near-cognate start codon. The resulting polyglycine-containing protein, but not repeat RNA, is pathogenic by disrupting the nuclear lamina.
Fen-Biao, Gao, Joel D, Richter
openaire +2 more sources
Vectorette PCR isolation of microsatellite repeat sequences using anchored dinucleotide repeat primers [PDF]
Nucleic Acids Research, 1996 We have developed a vectorette PCR approach to provide an improved method for isolation of microsatellite repeats. The modified procedure relies on PCR amplification using a vectorette-specific primer in combination with one of a panel of anchored dinucleotide repeat primers.
Nicholas Lench
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BioTechniques, 2003 We developed a technique to improve the efficiency of producing TAA repeat microsatellite markers linked to interspecific conserved genes. Template DNA was prepared from cultures derived from single bacterial artificial chromosome (BAC) colonies using a ...
Geoffrey C. Waldbieser +2 more
doaj +1 more source