Results 31 to 40 of about 28,396 (290)

RNA biology of disease-associated microsatellite repeat expansions [PDF]

Acta Neuropathologica Communications, 2017
Microsatellites, or simple tandem repeat sequences, occur naturally in the human genome and have important roles in genome evolution and function. However, the expansion of microsatellites is associated with over two dozen neurological diseases. A common denominator among the majority of these disorders is the expression of expanded tandem repeat ...
Kushal J. Rohilla, Keith T. Gagnon
openaire   +3 more sources

Microsatellite development from genome skimming and transcriptome sequencing: comparison of strategies and lessons from frog species

BMC Genomics, 2018
Background Even though microsatellite loci frequently have been isolated using recently developed next-generation sequencing (NGS) techniques, this task is still difficult because of the subsequent polymorphism screening requires a substantial amount of ...
Yun Xia, Wei Luo, Siqi Yuan, Yuchi Zheng, Xiaomao Zeng   +4 more
doaj   +1 more source

Frameshift mutations at coding mononucleotide repeat microsatellites in endometrial carcinoma with microsatellite instability [PDF]

Cancer, 2000
Microsatellite instability (MI) is a frequent occurrence in endometrioid carcinoma of the endometrium (EC). Several genes known to contain mononucleotide short tracts in their coding sequences (TGF-beta RII, IGFIIR, BAX, hMSH6, and hMSH3) are likely targets for mutations in these tumors.DNA from 24 patients with EC and MI was extracted from blood and ...
Lluis Catasus, Xavier Matias Guiu, Pilar Machin, Gian Franco Zannoni, Giovanni Scambia, BENEDETTI PANICI, PIERLUIGI, Jaime Prat   +6 more
openaire   +3 more sources

Cytogenetic characterisation and chromosomal mapping of microsatellite and telomeric repeats in two gecko species (Reptilia, Gekkonidae) from Thailand [PDF]

, 2021
Weera Thongnetr, Surachest Aiumsumang, Rodjarin Kongkaew, Alongklod Tanomtong, Chatmongkon Suwannapoom, Sumalee Phimphan   +5 more
openalex   +2 more sources

Functional and immunological relevance of Anaplasma marginale major surface protein 1a sequence and structural analysis.

PLoS ONE, 2013
Bovine anaplasmosis is caused by cattle infection with the tick-borne bacterium, Anaplasma marginale. The major surface protein 1a (MSP1a) has been used as a genetic marker for identifying A.
Alejandro Cabezas-Cruz, Lygia M F Passos, Katarzyna Lis, Rachel Kenneil, James J Valdés, Joana Ferrolho, Miray Tonk, Anna E Pohl, Libor Grubhoffer, Erich Zweygarth, Varda Shkap, Mucio F B Ribeiro, Agustín Estrada-Peña, Katherine M Kocan, José de la Fuente   +14 more
doaj   +1 more source

Repeat expansions confer WRN dependence in microsatellite-unstable cancers [PDF]

Nature, 2020
The RecQ DNA helicase WRN is a synthetic lethal target for cancer cells with microsatellite instability (MSI), a form of genetic hypermutability that arises from impaired mismatch repair1-4. Depletion of WRN induces widespread DNA double-strand breaks in MSI cells, leading to cell cycle arrest and/or apoptosis.
Niek van Wietmarschen, Sriram Sridharan, William J. Nathan, Anthony Tubbs, Edmond M. Chan, Elsa Callen, Wei Wu, Frida Belinky, Veenu Tripathi, Nancy Wong, Kyla Foster, Javad Noorbakhsh, Kiran Garimella, Abimael Cruz-Migoni, Joshua A. Sommers, Yongqing Huang, Ashir A. Borah, Jonathan T. Smith, Jeremie Kalfon, Nikolas Kesten, Kasper Fugger, Robert L. Walker, Egor Dolzhenko, Michael A. Eberle, Bruce E. Hayward, Karen Usdin, Catherine H. Freudenreich, Robert M. Brosh, Stephen C. West, Peter J. McHugh, Paul S. Meltzer, Adam J. Bass, André Nussenzweig   +32 more
openaire   +4 more sources

Quasimonomorphic Mononucleotide Repeats for High‐Level Microsatellite Instability Analysis [PDF]

Disease Markers, 2004
Microsatellite instability (MSI) analysis is becoming more and more important to detect sporadic primary tumors of the MSI phenotype as well as in helping to determine Hereditary Non‐Polyposis Colorectal Cancer (HNPCC) cases. After some years of conflicting data due to the absence of consensus markers for the MSI phenotype, a meeting held in Bethesda ...
Asad Umar, Olivier Buhard, Nirosha Suraweera, Aude Lectard, Alex Duval, Richard Hamelin   +5 more
openaire   +2 more sources

Microsatellite Markers for the New Zealand Endemic Tree Fuchsia excorticata (Onagraceae)

Applications in Plant Sciences, 2013
Premise of the study: Microsatellite markers were developed from a New Zealand endemic understory tree, Fuchsia excorticata, to investigate factors affecting the mating system.
Megan L. Van Etten, Alastair W. Robertson, Jennifer A. Tate   +2 more
doaj   +1 more source

APMicroDB: A microsatellite database of Acyrthosiphon pisum

Genomics Data, 2017
Pea aphids represent a complex genetic system that could be used for QTL analysis, genetic diversity and population genetics studies. Here, we described the development of first microsatellite repeat database of the pea aphid (APMicroDB), accessible at ...
Ritika Bishnoi, Deepak Singla
doaj   +1 more source

Analysis of microsatellite polymorphism in inbred knockout mice. [PDF]

PLoS ONE, 2012
Previously, we found that the genotype of 42 out of 198 mouse microsatellite loci, which are distributed among all chromosomes except the Y chromosome, changed from monomorphism to polymorphism (CMP) in a genetically modified inbred mouse strain. In this
Baofen Zuo, Xiaoyan Du, Jing Zhao, Huixin Yang, Chao Wang, Yanhua Wu, Jing Lu, Ying Wang, Zhenwen Chen   +8 more
doaj   +1 more source