Results 101 to 110 of about 51,470 (255)

Identification of Active Compounds of Centipeda minima for Potentiating Tumor Immunotherapy in Non‐Small Cell Lung Cancer via FANCD2‐cGAS/STING/IFN‐I Signaling Axis

Phytotherapy Research, EarlyView.
Schematic diagram illustrating the underlying mechanisms by which ECM and its active components activate the FANCD2‐cGAS/STING/IFN‐I signaling axis, thus enhancing the therapeutic efficacy of anti‐PD‐1 in NSCLC. ABSTRACT Activation of cGAS/STING/IFN‐I signaling pathway serves as a potential therapeutic strategy to enhance CD8+ T cells infiltration and ...
Han‐Chen Wang, Chu‐Ying Chen, Jiang‐Tao Xiao, Rou‐Qiao Zheng, Wen‐Da He, Zi‐Wei Xu, Su‐Fen Wei, Tao Su, Guang‐Biao Zhou, Yong‐Qiang Liu   +9 more
wiley   +1 more source

Evaluation and assimilation of Arctic Weather Satellite data in the AROME‐Arctic forecast system

Quarterly Journal of the Royal Meteorological Society, EarlyView.
The Arctic Weather Satellite (AWS), launched in August 2024, is a prototype for the future EPS–Sterna constellation of small satellites carrying an innovative microwave sounder. We present the first assessment of AWS in the regional AROME‐Arctic numerical weather prediction system, covering post‐launch calibration results and the impact of AWS ...
Stéphanie Guedj, Per Dahlgren, Máté Mile   +2 more
wiley   +1 more source

Targeting the CD47–SIRPα phagocytic checkpoint in cancer: Biology, translational opportunities, and next‐generation therapeutic strategies

Smart Molecules, EarlyView.
The CD47–SIRPα axis has emerged as a critical innate immune checkpoint that suppresses macrophage‐mediated phagocytosis through a canonical “don't eat me” signal and enables tumor immune evasion. We comprehensively summarize the structural and biological features of CD47 and the molecular mechanisms underlying CD47‐mediated regulation of phagocytosis ...
Ruimei Zhou, Lingjie Jing, Jianping Zhang, Cheng Guo, Quanjun Yang   +4 more
wiley   +1 more source

Nanobodies as next‐generation targeting platforms: From discovery technologies to translational biomedicine

VIEW, EarlyView.
Nanobodies, derived from the variable domains of camelid heavy‐chain‐only antibodies, have emerged as transformative biomedical tools due to their nanoscale size, exceptional stability, and unique capacity to recognize cryptic epitopes. This review provides a comprehensive overview of the field, outlining the structural and biochemical features of ...
Zhenrui Ye, Xianyang Li, Meixiao Zhan
wiley   +1 more source

Prioritizing areas for wolf management in Austria by modelling potential habitat and depredation risk

Wildlife Biology, EarlyView.
The recovery of wolf populations across Europe has reignited human–wildlife conflicts, particularly in countries such as Austria, where wolves have been absent for more than a century. Livestock depredation remains one of the primary sources of tension, and effective management requires a solid spatial basis for planning.
Florian Kunz, Luca Fuchs, Matthias Amon, Klaus Hackländer, Jörg Fabian Knufinke, Jennifer Hatlauf   +5 more
wiley   +1 more source

Biology, ecology, and conservation of the Italian hare Lepus corsicanus: a review

Wildlife Biology, EarlyView.
The Italian hare Lepus corsicanus, an endemic lagomorph of Italy, serves as a critical case study in evolutionary biology and conservation. Once taxonomically debated, modern genetic and morphological analyses confirm its status as a distinct Pleistocene lineage restricted to the central‐southern Italian Peninsula and Sicily.
Pierangelo Freschi, Valter Trocchi
wiley   +1 more source

Genomic distribution characteristics and interspecific differences of microsatellite landscapes in Felidae. [PDF]

BMC Genomics
Dou H, Xi H, Li Y, Yang H, Zhang H, Wang F.   +5 more
europepmc   +1 more source

High thermal plasticity, low heritability and constant directional selection on breeding phenology in a viviparous ectotherm

Journal of Animal Ecology, EarlyView.
Our findings reveal that breeding phenology of the common lizard is shaped by strong thermal plasticity, body size effects, constant selection for earlier parturition, but low heritability. This suggests that phenological responses to climate change in this species, and likely in other squamates, will predominantly arise through plastic rather than ...
Théo Bodineau, Alexis Rutschmann, Jean‐François Le Galliard, Manuel Massot, Murielle Richard, Jean Clobert, Sandrine Meylan, Pierre de Villemereuil   +7 more
wiley   +1 more source

The DBD-α4 helix of EWSR1::FLI1 is required for GGAA microsatellite binding that underlies genome regulation in Ewing sarcoma. [PDF]

Elife
Bayanjargal A, Taslim C, Showpnil IA, Selich-Anderson J, Crow JC, Zhou R, Lessnick SL, Theisen ER.   +7 more
europepmc   +1 more source

The Size, Demography, and Distribution of Cambodia's Largest Elephant Population Revealed Using Traditional Genetic Tools and a Novel SNP Panel

Integrative Zoology, EarlyView.
Asian elephant population parameters were assessed using microsatellite, SNP, and sex determination DNA markers. This represents one of the first studies in mainland Asia to demonstrate that integrating microsatellite and SNP data enhances genotyping success from degraded fecal samples, increases the number of useable samples and markers, and ...
Rachel Crouthers, Wayne Linklater, Peter Ritchie, Visattha In, Chanrith Phoeurk, Alexander Ball   +5 more
wiley   +1 more source