Results 91 to 100 of about 51,470 (255)

Characterization of microsatellites with Duplex Sequencing

, 2018
Microsatellites are highly unstable regions in the human genome. If mutations occur in the germline they might be transmitted to the offspring and therefore bear a high risk of influenc-ing future generations.
Ortner, Patrick
core   +2 more sources

Revisiting an important component of plant genomes: microsatellites

, 2013
Microsatellites are some of the most highly variable repetitive DNA tracts in genomes. Few studies focus on whether the characteristic instability of microsatellites is linked to phenotypic effects in plants.
Mason, Annaliese S., Wang, Wei, Ren, Xiaodong, Gao, Caihua, Fu, Donghui, Li, Jiana, Xiao, Meili   +6 more
core   +1 more source

Hybridization patterns and research effort in Asteraceae, a megadiverse and economically important plant family

PLANTS, PEOPLE, PLANET, EarlyView.
Plant hybridization is increasingly recognized as an important evolutionary process, and a deeper understanding of hybridization is necessary for its application to agriculture, conservation, and ecological solutions. Here, we assess correlates of hybridization in the megadiverse and societally important family Asteraceae and how and where hybrids have
Leandra O′Connell, Kathryn G. Turner, Nora Mitchell   +2 more
wiley   +1 more source

Needle in a haystack: Holocene history of European larch in Central Europe revisited

PLANTS, PEOPLE, PLANET, EarlyView.
Defining nativity of species is crucial for their management. However, this is a complex task, especially for species that have been used and spread by humans for a long time. We combined paleoecological records with extensive genetic data to investigate the Holocene history of European larch—a common and economically important tree species in Central ...
Martin Prach, Petr Pokorný, Kristýna Hošková, Daniel Vondrák, Pavel Bednář, Jindřich Prach, Jana Hanzal Šedivá, Hana Drahošová, Kateřina Podrábská, Přemysl Bobek, Jan Smyčka, Tomáš Fér   +11 more
wiley   +1 more source

Precision medicine in cancer: A comprehensive review of advanced cancer diagnosis technologies and personalized treatment strategies

Precision Medical Sciences, EarlyView.
The translational pipeline of precision medicine in clinical oncology. Schematic overview of the individualized cancer care workflow. (1) Input: Patient samples undergo multi‐omic profiling via NGS, single‐cell diagnostics, spatial maps, and epigenetic sequencing.
Asif Jan, Bushra Waheed, Rani Akbar, Daniel Dubwa   +3 more
wiley   +1 more source

First genome sequence of a European Alternaria brassicae isolate and genes involved in early development of alternaria leaf spot on Brassica juncea

Pest Management Science, EarlyView.
This article reports the first genome sequence of a UK Alternaria brassicae isolate. Dual RNA‐sequencing profiling of A. brassicae‐infected Brassica juncea leaves identified differentially expressed genes involved in pathogenicity and host response pathways in moderately resistant Sej‐2 (2) and moderately susceptible Pusa Jaikisan cultivars.
Kevin M. King, Graham McLaughlin, Chinthani S. Karandeni Dewage, Zedi Gao, David J. Hughes, Jonathan S. West, Henrik U. Stotz   +6 more
wiley   +1 more source

Ancient and Modern Genomes Reveal Microsatellites Maintain a Dynamic Equilibrium Through Deep Time

Microsatellites are widely used in population genetics, but their evolutionary dynamics remain poorly understood. It is unclear whether microsatellite loci drift in length over time.
Lambert, David M., McComish, Bennet J., Holland, Barbara R., McComish, Bennet J, Parks, Matthew, Zhang, Guojie, Millar, Craig D., Charleston, Michael A, Li, Ruiqiang, Holland, Barbara R, Charleston, Michael A., Lambert, David M, Millar, Craig D, Baroni, Carlo, Salvatore, Maria Cristina   +14 more
core   +1 more source

Transcriptomic resources and functional validation of RNAi in the cabbage seedpod weevil, Ceutorhynchus obstrictus

Pest Management Science, EarlyView.
Transcriptome sequencing of Ceutorhynchus obstrictus revealed RNA interference (RNAi) targets; double‐stranded RNA microinjection reduced transcript levels and increased mortality, with αCOP and Rop showing strongest lethal effects, indicating promising RNAi‐based pest control candidates.
Apurva Vikas Sabnis, Triin Kallavus, Éricmar Avila Dos Santos, Liina Soonvald, Riina Kaasik, Silva Vilumets, Clauvis Nji Tizi Taning, Kristof De Schutter, Eve Veromann   +8 more
wiley   +1 more source

Fitness landscapes of human microsatellites.

Advances in DNA sequencing technology and computation now enable genome-wide scans for natural selection to be conducted on unprecedented scales. By examining patterns of sequence variation among individuals, biologists are identifying genes and variants
Ryan J Haasl, Bret A Payseur
core   +1 more source

The first report of M918L (super‐kdr) and L932F voltage‐gated sodium channel mutations in the English grain aphid (Sitobion avenae)

Pest Management Science, EarlyView.
The study has identified mutations in the voltage gated sodium channel of the English grain aphid (Sitobion avenae) at M918 and L932, which have not been previously reported in this species. Abstract BACKGROUND The grain aphid, Sitobion avenae Fabricius (Hemiptera: Aphididae), is a vector of yellow dwarf viruses and an important pest of cereals.
Virgile Ballandras, Louise McNamara, James C Carolan, Tom Ruttink, Stephen Byrne   +4 more
wiley   +1 more source