Results 71 to 80 of about 211,987 (323)

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin   +11 more
wiley   +1 more source

LASIL: Learner-Aware Supervised Imitation Learning For Long-Term Microscopic Traffic Simulation [PDF]

open access: yesComputer Vision and Pattern Recognition
Microscopic traffic simulation plays a crucial role in transportation engineering by providing insights into in-dividual vehicle behavior and overall traffic flow.
Ke Guo   +6 more
semanticscholar   +1 more source

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

open access: yesAdvanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley   +12 more
wiley   +1 more source

Modeling electric bike–car mixed flow via social force model

open access: yesAdvances in Mechanical Engineering, 2017
Because of the convenience and the quickness, electric bikes gradually become the main travel mode of urban resident in China, and electric bike–car mixed flow becomes the new characteristics of urban traffic flow.
Zhao-wei Qu   +5 more
doaj   +1 more source

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

open access: yesAdvanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz   +3 more
wiley   +1 more source

Fokker-Planck Asymptotics for Traffic Flow Models

open access: yes, 2010
Starting from microscopic interaction rules we derive kinetic models of Fokker--Planck type for vehicular traffic flow. The derivation is based on taking a suitable asymptotic limit of the corresponding Boltzmann model.
Herty, M., Pareschi, L.
core   +1 more source

Microscopic Modelling of the Area-Based Traffic Flow [PDF]

open access: yes, 2019
Area-based (i.e., non-lane based) heterogeneous traffic (as in developing countries) differs significantly from lane-based homogeneous traffic (as in developed countries). In area-based traffic, drivers generally ignore the lane markings and perceive the entire road space while progressing longitudinally.
openaire   +2 more sources

Fluorescent Nanodiamonds Based Theranostic Platform for pH‐Sensitive Drug Delivery and Quantum Sensing

open access: yesAdvanced Functional Materials, EarlyView.
A multifunctional nanodiamond platform enables pH‐triggered Diazoxide (DZX) delivery and quantum sensing of subcellular radical dynamics in triple‐negative breast cancer cells. Diamond relaxometry revealed reduced lysosomal radicals during DZX‐induced mitochondrial radical elevation, providing insights into redox modulation and organelle‐ resolved ...
Kaiqui Wu   +8 more
wiley   +1 more source

Development of Eco-Friendly Ramp Control for Connected and Automated Electric Vehicles [PDF]

open access: yes, 2020
With on-board sensors such as camera, radar, and Lidar, connected and automated vehicles (CAVs) can sense the surrounding environment and be driven autonomously and safely by themselves without colliding into other objects on the road. CAVs are also able
Barth, Matthew J.   +3 more
core  

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

open access: yesAdvanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj   +21 more
wiley   +1 more source

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