Results 31 to 40 of about 24,113 (256)
Antibiotics, 2022 The drug salinomycin (SAL) is a polyether antibiotic and used in veterinary medicine as coccidiostat and growth promoter. Recently, SAL was suggested as a potential anticancer drug.
Lisa Knoche +3 more
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Cells, 2022 The characterization of novel radiotracers toward their metabolic stability is an essential part of their development. While in vitro methods such as liver microsome assays or ex vivo blood or tissue samples provide information on overall stability ...
Sandy Lemm +6 more
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The Journal of Cell Biology, 1956 The pancreatic exocrine cell of the guinea pig has a voluminous endoplasmic reticulum distinguished by extensive association with small, dense particles, and by its orderly disposition in the basal region of the cell. In addition to the small, (∼15 mµ), dense particles attached to the limiting membrane of the endoplasmic reticulum ...
G. E. Palade, P. Siekevitz
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Frontiers in Chemistry, 2019 In this study, the metabolic profiles of a new illicit drug AMB-FUBINACA were investigated using both human liver microsome and zebrafish models. Liquid chromatography Q Extractive HF Hybrid Quadrupole-Orbitrap mass spectrometry (LC-QE-HF-MS) was ...
Duo-qi Xu +5 more
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The Journal of Cell Biology, 1956 Rat liver, liver homogenates, and microsome fractions separated therefrom were examined systematically in the electron microscope in sections of OsO4-fixed, methacrylate-embedded tissue and pellets. It was found that most microsomes are morphologically identical with the rough surfaced elements of the endoplasmic reticula of hepatic ...
G. E. Palade, P. Siekevitz
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Bio-Protocol, 2017 The plant endomembrane system plays vital roles for synthesis, modification and secretion of proteins and lipids. From the classic view, only mRNAs encoding secreted proteins could be targeted to the endoplasmic reticulum (ER) for translation via a co ...
Yonghui Zhao, Shengben Li
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Stem Microsome Preparation and Mannan Synthase Activity Assay
Bio-Protocol, 2013 Mannans are hemicellulosic polysaccharides and are present in cell walls of all land plants. Mannan polysaccharides are synthesized by two enzymes, mannan synthase (ManS) for backbone (mannan or glucomannan) synthesis and galactomannan galactosyl ...
Yan Wang
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Molecules, 2012 A HPLC-ESI-IT-MSn method, based on high-performance liquid chromatography coupled to electrospray negative ionization multistage ion trap mass spectrometry, was developed for rapid identification of 24 flavonoid and naphthopyranone compounds.
Wagner Vilegas +6 more
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Pharmaceutics, 2021 Repaglinide (RPG), a rapid-acting meglitinide analog, is an oral hypoglycemic agent for patients with type 2 diabetes mellitus. Quercetin (QCT) is a well-known antioxidant and antidiabetic flavonoid that has been used as an important ingredient in many ...
Ji-Min Kim +4 more
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Evaluation the inhibitory effect of nicardipine on the metabolism of quetiapine
Frontiers in PharmacologyThe aim of this study was to investigate the impact of calcium channel blockers (CCBs) and antihypertensive traditional Chinese medicine (TCM) on the metabolism of quetiapine. In vitro, two incubation systems of rat liver microsomes (RLM) and human liver
Jinzhao Yang +5 more
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