Results 31 to 40 of about 50,037 (190)

Stem Microsome Preparation and Mannan Synthase Activity Assay

Bio-Protocol, 2013
Mannans are hemicellulosic polysaccharides and are present in cell walls of all land plants. Mannan polysaccharides are synthesized by two enzymes, mannan synthase (ManS) for backbone (mannan or glucomannan) synthesis and galactomannan galactosyl ...
Yan Wang
doaj   +1 more source

Analyses of CYP2C in Porcine Microsomes [PDF]

Basic & Clinical Pharmacology & Toxicology, 2008
Abstract: The cytochrome P450 2C (CYP2C) subfamily in human beings includes four different isoenzymes that metabolize different substrates although with some cross reactivity. Some of these substrates (e.g. diclofenac and tolbutamide), have been investigated in porcine microsomes, but without identifying the specific CYP catalysing the reactions.
Skaanild, Mette Tingleff, Friis, Christian   +1 more
openaire   +5 more sources

Strategic use of plasma and microsome binding to exploit in vitro clearance in early drug discovery.

ACS Medicinal Chemistry Letters, 2010
Apparent intrinsic clearance (CLia) determined from microsomal stability assays is a cornerstone in drug discovery. Categorical bins are routinely applied to this end point to facilitate analysis.
G. Chang, Stefanus J. Steyn, J. Umland, D. Scott   +3 more
semanticscholar   +1 more source

Liver kidney microsome antibodies. Analysis of a laboratory series

Practical Laboratory Medicine, 2023
Objectives: The objectives were to characterize the liver kidney microsome (LKM) antibody profile of a 14-month-old girl with autoimmune hepatitis and analyze the laboratory prevalence of LKM positivity. Design and methods: This is retrospective analysis
Sandra Sanchez, Diana Fang, Shaoming Xiao, Lu Ann Rezavi, Brittney M. Howard, Patrizio Caturegli, Daniela Cihakova   +6 more
doaj  

Characterization and Quantification of the Compounds of the Ethanolic Extract from Caesalpinia ferrea Stem Bark and Evaluation of Their Mutagenic Activity

Molecules, 2014
Caesalpinia ferrea Martius has traditionally been used in Brazil for many medicinal purposes, such as the treatment of bronchitis, diabetes and wounds.
Carlos César Wyrepkowski, Daryne Lu Maldonado Gomes da Costa, Adilson Paulo Sinhorin, Wagner Vilegas, Rone Aparecido De Grandis, Flavia Aparecida Resende, Eliana Aparecida Varanda, Lourdes Campaner dos Santos   +7 more
doaj   +1 more source

The Influence of CYP3A4 Genetic Polymorphism and Proton Pump Inhibitors on Osimertinib Metabolism

Frontiers in Pharmacology, 2022
The aim of this study was to 1) investigate the effects of 27 CYP3A4 variants on the metabolism of osimertinib and 2) study the interactions between osimertinib and others as well as the underlying mechanism.
Nanyong Gao, Xiaodan Zhang, Xiaodan Zhang, Xiaoqin Hu, Qihui Kong, Jianping Cai, Guoxin Hu, Jianchang Qian   +7 more
doaj   +1 more source

Differences in metabolite-mediated toxicity of tamoxifen in rodents versus humans elucidated with DNA/microsome electro-optical arrays and nanoreactors.

Chemical Research in Toxicology, 2009
Tamoxifen, a therapeutic and chemopreventive breast cancer drug, was chosen as a model compound because of acknowledged species specific toxicity differences.
Linlin Zhao, S. Krishnan, Yun Zhang, J. Schenkman, J. Rusling   +4 more
semanticscholar   +1 more source

Blue rayon e teste Salmonella/microssoma na avaliação da qualidade de águas costeiras Blue rayon and Salmonella/microsome assay in the evaluation of coastal water quality

Revista de Saúde Pública, 2006
OBJETIVO: Desenvolver estratégia para o monitoramento passivo das águas do estuário de Santos quanto à presença de atividade genotóxica e de hidrocarbonetos policíclicos aromáticos. MÉTODOS: Estudo realizado no estuário de Santos, Estado de São Paulo, em
Fábio Kummrow, Dulce Magalhães, Alexandre Franco, Gisela de Aragão Umbuzeiro   +3 more
doaj   +1 more source

Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.

Proceedings of the National Academy of Sciences of the United States of America, 1990
Thapsigargin, a tumor-promoting sesquiterpene lactone, discharges intracellular Ca2+ in rat hepatocytes, as it does in many vertebrate cell types. It appears to act intracellularly, as incubation of isolated rat liver microsomes with thapsigargin induces
O. Thastrup, P. Cullen, B. Drøbak, M. Hanley, A. Dawson   +4 more
semanticscholar   +1 more source

Metabolic Profiling of the Uncaria Hook Alkaloid Geissoschizine Methyl Ether in Rat and Human Liver Microsomes Using High-Performance Liquid Chromatography with Tandem Mass Spectrometry

Molecules, 2015
Geissoschizine methyl ether (GM) is an indole alkaloid found in Uncaria hook, which is a galenical constituent of yokukansan, a traditional Japanese medicine. GM has been identified as the active component responsible for anti-aggressive effects. In this
Hirotaka Kushida, Takashi Matsumoto, Yasushi Igarashi, Hiroaki Nishimura, Junko Watanabe, Kazuya Maemura, Yoshio Kase   +6 more
doaj   +1 more source