Results 1 to 10 of about 26,828 (241)
Biosynthesis of presqualene pyrophosphate by liver microsomes
Journal of Lipid Research, 1970 Microsomes from rat liver have been shown to synthesize a squalene precursor from farnesyl pyrophosphate. This intermediate is identical with presqualene pyrophosphate, a 30-carbon cyclopropane containing pyrophosphate ester that had previously been ...
H.C. RILLING
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Preclinical metabolism and metabolic drug–drug interaction profile of pedunculoside and rotundic acid [PDF]
Clinical and Translational SciencePedunculoside and rotundic acid, the most abundant components in plants of the genus Ilex L. (Aquifoliaceae), exhibit biological and pharmacological significance in the treatment of cardiovascular diseases.
Liang Wu +8 more
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Foods, 2021 Nontargeted analysis can be used for the rapid screening and confirmatory analysis of veterinary drugs and their metabolites, which are important for the comprehensive safety evaluation of animal-derived foods.
Bo Wang +5 more
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The composition of rat liver microsomes. The structural proteins of rat liver microsomes [PDF]
Biochemical Journal, 1969 1. The structural-protein component of microsomal membranes was isolated by three separate methods. Analysis by polyacrylamide-gel electrophoresis indicated that the microsomal structural component is made up of a heterogeneous group of proteins. These proteins were further characterized by their phospholipid-binding capacity.
J. K. Pollak, K. A. Ward
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EFFECT OF TRYPSIN ON LIVER MICROSOMES [PDF]
The Journal of Cell Biology, 1963 The effect of trypsin on the morphology of the rat liver microsomal fraction isolated by differential centrifugation has been investigated. The microsomes were incubated at 37°C and centrifuged thereafter under the conditions of their initial isolation.
J Lust, Pierre Drochmans
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Characterization of Frequency-Dependent Material Properties of Human Liver and its Pathologies Using an Impact Hammer [PDF]
Medical Image Analysis, 2011, Vol. 15, No.1, pp. 45-52, 2021 The current methods for characterization of frequency-dependent material properties of human liver are very limited. In fact, there is almost no data available in the literature showing the variation in dynamic elastic modulus of healthy or diseased human liver as a function of excitation frequency.
arxiv +1 more source
Pharmaceutics, 2021 Eudesmin, fargesin, epimagnolin A, magnolin, and yangambin are tetrahydrofurofuranoid lignans with various pharmacological activities found in Magnoliae Flos.
Ria Park +6 more
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Microsomal Esterase of Rat Liver [PDF]
Journal of Biological Chemistry, 1969 Abstract Rat liver microsomal esterase has been purified 254-fold by a combination of solubilization in a mechanical cell homogenizer, acetone and ammonium sulfate precipitations, and hydroxylapatite column chromatography. The enzyme hydrolyzed glyceryl 1-monodecanoate at a rapid rate; the Km is 1.61 x 10-3 m.
K. Hayase, Al L. Tappel
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Pharmacology Research & Perspectives, 2020 Ataluren promotes ribosomal readthrough of premature termination codons in mRNA which result from nonsense mutations. In vitro studies were performed to characterize the metabolism and enzyme kinetics of ataluren and its interaction potential with CYP ...
Ronald Kong +9 more
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Metabolism studies of paeoniflorin in rat liver microsomes by ultra-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS/MS) [PDF]
Royal Society Open Science, 2018 To explore metabolism mechanism of paeoniflorin in the liver and further understand intact metabolism process of paeoniflorin, a rapid, convenient and effective assay is described using ultra-performance liquid chromatography coupled with hybrid ...
L. J. Zhu +3 more
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