Results 91 to 100 of about 26,827 (219)

Clofibric Acid Increases the Formation of Oleic Acid in Endoplasmic Reticulum of the Liver of Rats

Journal of Pharmacological Sciences, 2011
.: The effects of 2-(4-chlorophenoxy)-2-methylpropionic acid (clofibric acid) on the formation of oleic acid (18:1) from stearic acid (18:0) and utilization of the 18:1 formed for phosphatidylcholine (PC) formation in endoplasmic reticulum in the liver ...
Akihiko Hirose, Tohru Yamazaki, Takeshi Sakamoto, Katsuyoshi Sunaga, Tadashi Tsuda, Atsushi Mitsumoto, Naomi Kudo, Yoichi Kawashima   +7 more
doaj   +1 more source

Tryptophan Suppresses FTH1‐Driven Ferritinophagy, a Key Correlate of Prognosis in Hepatocellular Carcinoma

Cell Proliferation, EarlyView.
Intracellular tryptophan levels modulate selective autophagy of FTH1 via the NCOA4 pathway. This autophagic process then inhibits 6‐HMT synthesis, which then results in an increase in reactive oxygen species and ferroptosis. ABSTRACT Hepatocellular carcinoma (HCC) remains a lethal malignancy with limited therapeutic options.
Xinxiang Cheng, Xin Ge, Chi Zhang, Xingye Yang, Zhengxin Yu, Min Zhang, Wen Cao, Qingtao Ni, Yang Liu, Songbing He, Yin Yuan   +10 more
wiley   +1 more source

The Role of Oxidative Stress in Periodontitis

Journal of Periodontal Research, EarlyView.
Oxidative stress is involved in multiple chemical reactions that take place in different intracellular organelles: mitochondria, rough endoplasmic reticulum, peroxisomes, autophagy, and aging, and can be influenced by exogenous factors: nutrition, physical activity, psychological status, environmental conditions, microbiome, and drugs.
Pedro Bullon, Francesca Giampieri, Beatriz Bullon, Maurizio Battino   +3 more
wiley   +1 more source

Increased Apigenin in DNA‐Edited Hexaploid Wheat Promoted Soil Bacterial Nitrogen Fixation and Improved Grain Yield Under Limiting Nitrogen Fertiliser

Plant Biotechnology Journal, EarlyView.
ABSTRACT Nitrogen availability remains a principal constraint to crop productivity. Plants cannot directly assimilate the abundant nitrogen available in our atmosphere; instead, they rely on the uptake of inorganic forms of nitrogen, such as ammonium and nitrate from the soil.
Hiromi Tajima, Akhilesh Yadav, Javier Hidalgo Castellanos, Dawei Yan, Benjamin P. Brookbank, Eiji Nambara, Eduardo Blumwald   +6 more
wiley   +1 more source

Targets and strategies to design soybean seed composition traits

The Plant Genome, Volume 18, Issue 4, December 2025.
Abstract Breeders and geneticists have put great effort into enhancing soybean seed composition and developing elite varieties with desired traits. However, diverse end‐uses and changing consumer preferences present new challenges and opportunities to develop desired compositional profiles for the market.
Ritesh Kumar, Steven Mulkey, Rahul Mahadev Shelake, Rachel Combs‐Giroir, Thiya Mukherjee, Doug K. Allen, Tom Elmo Clemente, Minviluz G. Stacey, Aaron J. Lorenz, Robert M. Stupar   +9 more
wiley   +1 more source

A Hemochromogen Component of Liver Microsomes [PDF]

Proceedings of the National Academy of Sciences, 1952
Cornelius F. Strittmatter, Eric G. Ball
openaire   +2 more sources

Synthesis and In Vitro Metabolic Profiling of the Selective Androgen Receptor Modulator (SARM) LY305

Rapid Communications in Mass Spectrometry, Volume 39, Issue 22, 30 November 2025.
ABSTRACT Rationale 2‐Chloro‐4‐[[(1R,2R)‐2‐hydroxy‐2‐methyl‐cyclopentyl]amino]‐3‐methyl‐benzonitrile (LY305) is a transdermal selective androgen receptor modulator (SARM) that has been under development as a potential therapeutic for conditions involving muscle wasting, osteoporosis, or hypogonadism.
Giorgi Kobidze, Tristan Möller, Hui‐Chung Wen, Francesco Paolo Busardò, Mario Thevis   +4 more
wiley   +1 more source

Rewriting the MASLD‐associated hepatocellular carcinoma script: Targeting epigenetics and metabolism

International Journal of Cancer, Volume 157, Issue 10, Page 1991-2003, 15 November 2025.
Abstract Abnormal epigenetic patterns are crucial for the progression of metabolic‐associated steatotic liver disease (MASLD) and hepatocellular carcinoma (HCC) development. Recent research focused on the interplay between epigenetics and altered metabolic pathways in HCC from MASLD, suggesting that the reversibility of epigenetic changes offers ...
Chiara Aiello, Eric Felli, Teresa Musarra, Lorenzo Nevi, Annamaria Altomare, Jordi Gracia‐Sancho, Andrea Baiocchini, Simone Carotti   +7 more
wiley   +1 more source

IA‐0130, a novel 3‐(1,3‐diarylallylidene)oxindole derivative, alleviates ovarian cancer via inhibiting IL‐6/gp130/STAT3 signalling

British Journal of Pharmacology, Volume 182, Issue 22, Page 5670-5689, November 2025.
Background and Purpose Dysregulation of the IL‐6/glycoprotein 130(gp130)/STAT3 signalling axis is implicated in several human diseases, particularly cancer. Notably, gp130, a single transducer of this signalling axis, is a target for ovarian cancer treatment. However, data regarding small‐molecule inhibitors of gp130 are lacking. Therefore, we aimed to
Sun‐Ae Park, Hee Jung Kim, Lee Kyung Kim, Hae‐Ri Lee, Bo‐Kyung Jung, Ji Hyeon Kim, Myung Jin Kim, Tae Gwon Oh, Hee Eun Kang, Kye Jung Shin, Jae Hong Seo, Tae‐Hwe Heo   +11 more
wiley   +1 more source

Metabolic and vascular contributions to dementia: Soluble epoxide hydrolase‐derived linoleic acid oxylipins and glycemic status are related to cerebral small vessel disease markers, atrophy, and cognitive performance

Alzheimer's &Dementia, Volume 21, Issue 10, October 2025.
Abstract INTRODUCTION Type 2 diabetes mellitus (T2DM) is a risk factor for dementia and cerebral small vessel disease, but there remains a need to identify targetable molecular pathways involved in the underlying pathophysiology. METHODS In participants with Alzheimer's disease, related dementias, or cerebrovascular diseases, we assessed associations ...
Si Won Ryoo, William Z. Lin, Alexandra Magliocco, Myuri Ruthirakuhan, Yuen Yan Wong, Sofia E. Perfetto, Celine Huang, Natasha Z. Anita, Stephen R. Arnott, Anthony E. Lang, Sean Symons, Robert A. Hegele, Maged Goubran, Joel Ramirez, Julie Ottoy, Jennifer S. Rabin, Bradley J. MacIntosh, Krista L. Lanctôt, Nuanyi Liang, Hugo Cogo‐Moreira, Ameer Y. Taha, Walter Swardfager, the ONDRI Investigators   +22 more
wiley   +1 more source