Results 101 to 110 of about 26,827 (219)

Clinical and Genetic Analysis of Dehydrated Hereditary Stomatocytosis: A Case Report

Clinical Case Reports, Volume 13, Issue 10, October 2025.
ABSTRACT Dehydrated hereditary stomatocytosis (DHS) is a rare autosomal dominant hemolytic anemia caused by abnormal erythrocyte ion permeability, most often due to PIEZO1 mutations. We report the case of a 15‐year‐old male with elevated indirect bilirubin and mild anemia.
Chen Ming, Shiyuan Wu, Rui Pan
wiley   +1 more source

Gel Electrophoretic Detection of Black Market ACE‐031

Drug Testing and Analysis, Volume 17, Issue 10, Page 1934-1946, October 2025.
This article presents a study on black market ACE‐031 products and their detection by gel‐electrophoresis and Western blotting. Of the 14 tested products, only 12 contained an ACVR2B‐immunoreactive protein. However, mass spectrometry revealed that the products did not contain the ACVR2B‐Fc fusion protein ACE‐031 but instead the full‐length human ...
Christian Reichel, Thomas Filip, Günter Gmeiner, Mario Thevis   +3 more
wiley   +1 more source

A New Cytochrome in Liver Microsomes

Journal of Biological Chemistry, 1962
Ryo Sato, Tsuneo Omura
openaire   +3 more sources

Curcumin Nanocapsules Prepared With Native Casein Micelles Exhibit Potential to Reduce Paracetamol‐Induced Oxidative Stress

Food Science &Nutrition, Volume 13, Issue 10, October 2025.
Ameliorative potential of nano capsules of curcumin was evaluated in an animal model. Paracetamol overdose produced oxidative stress in the small animals. The increase in the level of blood serum biomarkers like creatinine, ALP, and GPT level was compensated by feeding nano capsules in curative and preventive formats.
Ankita Hooda, Bimlesh Mann, Abhishek Dutt Tripathi, Nandita Das, Himanshu Kumar Rai, Sulaxana Singh, Javed Masood Khan, Aparna Agarwal, Dipendra Kumar Mahato   +8 more
wiley   +1 more source

Monitoring Aflatoxin M1 in Milk From Selected Iranian Provinces Using Different Assays: Seasonal Trends and Processing Effects

Food Science &Nutrition, Volume 13, Issue 10, October 2025.
Rapid measurement of aflatoxin in milk is very important as a common toxin. It affects the acceptance of milk cargo. In this study, 227 milk samples were collected from different provinces of Iran, and their aflatoxin levels were measured using HPLC, ELISA, and immunochromatographic techniques.
Hamid Reza Fathali Beygi, Mojtaba Jafari, Zohreh Ashrafi, Bahram Hassani, Razie Razavi   +4 more
wiley   +1 more source

Altered Abundance of Butyrate‐Producing Lachnospiraceae by Maternal Diet During Pregnancy Potentially Influences MASLD‐Related Lipid Dysregulation in Male Rat Offspring

Molecular Nutrition &Food Research, Volume 69, Issue 19, October 2025.
Exposure to undernutrition or overnutrition during the critical period of pregnancy increases susceptibility to metabolic dysfunction‐associated steatotic liver disease (MASLD)–related lipid dysregulation in male rat offspring. The maternal diet during pregnancy altered the relative abundance of specific genera within the Lachnospiraceae family and ...
Soo‐Min Kim, Sunwha Park, AbuZar Ansari, Gain Lee, Young Min Hur, Jeongshin An, Sang Suk Lee, Young‐Ah You, Young Ju Kim   +8 more
wiley   +1 more source

Evidence for vitellogenin DNA‐binding in honey bees

Protein Science, Volume 34, Issue 10, October 2025.
Abstract DNA‐binding proteins play essential roles in DNA replication, DNA repair, DNA organization, and several aspects of gene regulation. Their well‐studied structures and charge configurations aid in identifying similar functions in other proteins. Vitellogenin (Vg) is a highly conserved protein that is central to egg‐yolk formation in most animal ...
Gyan Harwood, Vilde Leipart, Chris Elsik, Joseph C. F. Ng, Finn Drabløs, Gro V. Amdam   +5 more
wiley   +1 more source

Predicting Systemic and Liver Bosentan Exposure Using Physiologically‐Based Pharmacokinetic Modeling

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 10, Page 1715-1726, October 2025.
ABSTRACT Bosentan is the first approved oral medication for pulmonary arterial hypertension, yet the black‐box warning on its labeling implies a substantial risk of liver injury associated with bosentan exposure. The risk assessment of bosentan‐induced liver injury requires a thorough understanding of the underlying mechanisms, for which there is ...
Miao‐Chan Huang, Julia Macente, Sofie Heylen, Chen Ning, Kristof De Vos, Neel Deferm, Pieter Annaert   +6 more
wiley   +1 more source

PBPK Modeling to Predict Clinical Drug–Drug Interaction and Impact of Hepatic Impairment for an ADC With the Payload Auristatin F‐Hydroxypropylamide

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 10, Page 1661-1672, October 2025.
ABSTRACT Upifitamab rilsodotin—an antibody drug conjugate (ADC)—comprises a NaPi2b‐targeted antibody conjugated to an auristatin‐based payload (auristatin F‐hydroxypropylamide [AF‐HPA]). AF‐HPA is metabolized by cytochrome P450 3A4 (CYP3A4) and, to a lower extent, by CYP3A5 and demonstrates both reversible and time‐dependent inhibition of CYP3A4.
Niyanta Kumar, Vaishali Dixit, Howard Burt, Katherine L. Gill, Hannah M. Jones, Natalie Keirstead, Dian Su, Dorin Toader, Timothy B. Lowinger   +8 more
wiley   +1 more source

Assessing Cytochrome P450 Drug Interaction Risk for Dordaviprone Using Physiologically Based Pharmacokinetic Modeling

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 10, Page 1695-1704, October 2025.
ABSTRACT A physiologically based pharmacokinetic (PBPK) model was developed and verified for dordaviprone, a small molecule with antitumor effects in glioma patients. The model was applied to assess the drug–drug interaction (DDI) potential of dordaviprone as a victim of CYP3A4 inhibitors and inducers, and as a perpetrator of CYP3A4, CYP2C8, CYP2D6 ...
Swati Jaiswal, Nikunjkumar K. Patel, Hannah M. Jones, Savannah McFeely, Shamia L. Faison, Tim Tippin, Odin Naderer   +6 more
wiley   +1 more source