Results 101 to 110 of about 26,828 (241)

A Conditional Point Cloud Diffusion Model for Deformable Liver Motion Tracking Via a Single Arbitrarily-Angled X-ray Projection [PDF]

open access: yesarXiv
Deformable liver motion tracking using a single X-ray projection enables real-time motion monitoring and treatment intervention. We introduce a conditional point cloud diffusion model-based framework for accurate and robust liver motion tracking from arbitrarily angled single X-ray projections (PCD-Liver), which estimates volumetric liver motion by ...
arxiv  

Liver lesion segmentation informed by joint liver segmentation [PDF]

open access: yesarXiv, 2017
We propose a model for the joint segmentation of the liver and liver lesions in computed tomography (CT) volumes. We build the model from two fully convolutional networks, connected in tandem and trained together end-to-end. We evaluate our approach on the 2017 MICCAI Liver Tumour Segmentation Challenge, attaining competitive liver and liver lesion ...
arxiv  

End-to-End Discriminative Deep Network for Liver Lesion Classification [PDF]

open access: yesarXiv, 2019
Colorectal liver metastasis is one of most aggressive liver malignancies. While the definition of lesion type based on CT images determines the diagnosis and therapeutic strategy, the discrimination between cancerous and non-cancerous lesions are critical and requires highly skilled expertise, experience and time.
arxiv  

Deep Learning-Based Automatic Delineation of Liver Domes in kV Triggered Images for Online Breath-hold Reproducibility Verification of Liver Stereotactic Body Radiation Therapy [PDF]

open access: yesarXiv
Stereotactic Body Radiation Therapy (SBRT) can be a precise, minimally invasive treatment method for liver cancer and liver metastases. However, the effectiveness of SBRT relies on the accurate delivery of the dose to the tumor while sparing healthy tissue. Challenges persist in ensuring breath-hold reproducibility, with current methods often requiring
arxiv  

Activation of HMG-CoA reductase by microsomal phosphatase

open access: yesJournal of Lipid Research, 1983
HMG-CoA reductase activity can be modulated by a reversible phosphorylation-dephosphorylation with the phosphorylated form of the enzyme being inactive and the dephosphorylated form, active. Phosphatases from diverse sources, including cytosol, have been
K R Feingold   +4 more
doaj  

A Hemochromogen Component of Liver Microsomes [PDF]

open access: yesProceedings of the National Academy of Sciences, 1952
Cornelius F. Strittmatter, Eric G. Ball
openaire   +2 more sources

Middle‐Out Physiologically Based Pharmacokinetic Modeling to Support Pediatric Dosing Recommendation for Alectinib

open access: yesCPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Adult patients with anaplastic lymphoma kinase positive (ALK+) advanced non–small‐cell lung cancer (NSCLC) are treated with 600 mg alectinib twice daily (BID) as first‐line treatment. ALK positive solid and central nervous system (CNS) tumors are described in the pediatric population, with limited clinical data due to the rarity of the disease
Tamara van Donge   +6 more
wiley   +1 more source

Delving Deep into Liver Focal Lesion Detection: A Preliminary Study [PDF]

open access: yesarXiv, 2019
Hepatocellular carcinoma (HCC) is the second most frequent cause of malignancy-related death and is one of the diseases with the highest incidence in the world. Because the liver is the only organ in the human body that is supplied by two major vessels: the hepatic artery and the portal vein, various types of malignant tumors can spread from other ...
arxiv  

Mechanistic Physiologically Based Pharmacokinetic Modeling of Dry Powder and Nebulized Formulations of Orally Inhaled TMEM16A Potentiator GDC‐6988

open access: yesCPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT The orally inhaled route of administration for respiratory indications can maximize drug exposure to the site of action (lung) to increase efficacy while minimizing systemic exposure to achieve an improved safety profile. However, due to the difficulty of taking samples from different regions of the human lung, often only systemic ...
Rui Zhu   +12 more
wiley   +1 more source

Functional Imaging of CYP3A4 at Multiple Dimensions Using an AI‐Driven High Performance Fluorogenic Substrate

open access: yesSmall, EarlyView.
This study showcases a novel artificial intelligence (AI)‐driven design strategy for constructing highly specific and orally‐active fluorogenic substrates for imaging CYP3A4 in complex biological systems, while NFa emerged as a practical and reliable tool for sensing and imaging of CYP3A4 activity thus facilitating CYP3A4‐associated fundamental ...
Feng Zhang   +13 more
wiley   +1 more source

Home - About - Disclaimer - Privacy