Results 141 to 150 of about 26,828 (241)

Clofibric Acid Increases the Formation of Oleic Acid in Endoplasmic Reticulum of the Liver of Rats

Journal of Pharmacological Sciences, 2011
.: The effects of 2-(4-chlorophenoxy)-2-methylpropionic acid (clofibric acid) on the formation of oleic acid (18:1) from stearic acid (18:0) and utilization of the 18:1 formed for phosphatidylcholine (PC) formation in endoplasmic reticulum in the liver ...
Akihiko Hirose, Tohru Yamazaki, Takeshi Sakamoto, Katsuyoshi Sunaga, Tadashi Tsuda, Atsushi Mitsumoto, Naomi Kudo, Yoichi Kawashima   +7 more
doaj  

MetALD: New Perspectives on an Old Overlooked Disease

Liver International, Volume 45, Issue 5, May 2025.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) and alcohol‐associated liver disease (ALD) are the major contributors to the liver disease burden globally. The rise in these conditions is linked to obesity, type 2 diabetes, metabolic syndrome and increased alcohol consumption.
Gustavo Ayares, Luis Antonio Diaz, Francisco Idalsoaga, Naim Alkhouri, Mazen Noureddin, Ramon Bataller, Rohit Loomba, Juan Pablo Arab, Marco Arrese   +8 more
wiley   +1 more source

Stereospecificity of monoacylglycerol acyltransferase activity from rat intestine and suckling rat liver.

Journal of Lipid Research, 1986
The stereospecificity of monoacylglycerol acyltransferase from rat intestinal mucosa and suckling rat liver microsomes was examined using sn-1,2-diacylglycerol kinase from Escherichia coli.
R A Coleman, J P Walsh, D S Millington, D A Maltby   +3 more
doaj  

Liver microsomal protein content and activity in patients with hepatocellular carcinoma and cirrhosis: implications for the <i>in vivo</i> prediction of individual hepatic clearance. [PDF]

J Gastrointest Oncol
Zhou J, Gao N, Tian X, Fang Y, Gao J, Wen Q, Cui MZ, Zhang YF, Li SF, Jia LJ, Qiao HL.   +10 more
europepmc   +1 more source

Impact of Species and Tissue Differences on In Vitro Glucuronidation of Diclofenac. [PDF]

Molecules
Asare E, Emmanuel S, Du T, Xie H, Liang D, Gao S.   +5 more
europepmc   +1 more source

Dipeptidic Phosphonates: Potent Inhibitors of Pseudomonas aeruginosa Elastase B Showing Efficacy in a Murine Keratitis Model

Advanced Science, Volume 12, Issue 14, April 10, 2025.
A new series of highly potent dipeptidic phosphonates targeting the Pseudomonas aeruginosa protease LasB shows promising in vitro effects, favorable pharmacokinetics, good tolerability, and in vivo efficacy, highlighting their potential as a treatment for Pseudomonas keratitis when combined with meropenem. Abstract The ubiquitous opportunistic pathogen
Alexander F. Kiefer, Christian Schütz, Colya N. Englisch, Dominik Kolling, Samira Speicher, Andreas M. Kany, Roya Shafiei, Noran A. Wadood, Ahmad Aljohmani, Niklas Wirschem, Ravindra P. Jumde, Andreas Klein, Asfandyar Sikandar, Yu‐Mi Park, Gabriela Krasteva‐Christ, Daniela Yildiz, Ahmed S. Abdelsamie, Katharina Rox, Jesko Köhnke, Rolf Müller, Markus Bischoff, Jörg Haupenthal, Anna K. H. Hirsch   +22 more
wiley   +1 more source

Species Differences in the Biotransformation of Aflatoxin B1: Primary Determinants of Relative Carcinogenic Potency in Different Animal Species. [PDF]

Toxins (Basel)
Eaton DL, Williams DE, Coulombe RA.
europepmc   +1 more source

Targeting Histone Deacetylase 11 with a Highly Selective Inhibitor for the Treatment of MASLD

Advanced Science, Volume 12, Issue 15, April 17, 2025.
A potent HDAC11‐specific inhibitor, B6, is identified using substrate‐mimic and bioisosteric replacement strategies. B6 demonstrates high oral bioavailability, extensive liver distribution, and a favorable safety profile. B6 effectively alleviates metabolic dysfunction‐associated steatotic liver disease by increasing the expression of LKB1 and ...
Feng Zhang, Kairui Yue, Simin Sun, Shengyuan Lu, Geng Jia, Yang Zha, Shuang Zhang, C. James Chou, Chenzhong Liao, Xiaoyang Li, Yajun Duan   +10 more
wiley   +1 more source

Development of a near-infrared fluorescent probe for the selective detection of severe hypoxia. [PDF]

RSC Chem Biol
Kasai T, Fujita K, Komatsu T, Ueno T, Kojima R, Hanaoka K, Urano Y.   +6 more
europepmc   +1 more source

Carnosic Acid Directly Targets STING C‐Terminal Tail to Improve STING‐Mediated Inflammatory Diseases

Advanced Science, Volume 12, Issue 14, April 10, 2025.
This study presents carnosic acid (CA), an active ingredient of Rosmarinus officinalis L., dramatically ameliorates Trex1 deficiency‐mediated and STING‐dependent systemic inflammatory diseases by targeting STING C‐terminal tail (CTT) to disrupt STING activity.
Wenqing Mu, Guang Xu, Ling Li, Jincai Wen, Ye Xiu, Jia Zhao, Tingting Liu, Ziying Wei, Wei Luo, Huijie Yang, Zhixin Wu, Xiaoyan Zhan, Xiaohe Xiao, Zhaofang Bai   +13 more
wiley   +1 more source